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Biomedical subjects

E A Modianova

Publications and source records attributed to E A Modianova.

At least 19 recordsLinked to original sources
PubMed1991

[The ultrastructure of the hepatocyte contacts in inbred mice at different ages].

Correlation was revealed between the ultrastructure of hepatocyte contacts and force F, essential for the rupture of the junction between the cell, seized with a microneedle, and the tissue specimen, in mice of the highly cancerous CBA line and of the low cancerous C57BL line at the age of 1.7 and 15 months. The most considerable ultrastructural differences in the cell contacts were found in the above mice at the age of 1 month, when the signs of carcinogenic process cannot yet been seen. It is shown that the differences in force F of these mice are not associated with the structural changes in hepatocyte contacts which may be due to the differences in durability properties of the cytoskeleton.

Aging↗
PubMed1990

[Strength of intercellular adhesion in gastric cancer].

Intercellular adhesion strength was measured after Koman in various parts of primary tumor and lymph node metastases of 43 patients with stage III-IV gastric cancer. Also, a fraction of low-adhesion (less than 0.20 mg) cells was assayed. Intercellular adhesion strength was 0.518 +/- 0.039 mg in primary tumor, 0.260 +/- 0.045 mg--invasion zone and 0.145 +/- 0.028 mg--in metastases. The share of low-adhesion cells was found to be 8.85 +/- 0.26, 65 +/- 4.32 and 87.16 +/- 2.5%, respectively.

Adenocarcinoma↗
PubMed1990

[Action of carcinogenesis promoters on the adhesive force of cells in the liver, lung and thyroid gland in rats and mice].

The short-term effects of the carcinogenesis promoters on the adhesive force of cells are compared with the data from literature on their ability to exert a promoter action on the carcinogenesis development in the same organs during prolonged introduction after an initiator. The ability of substances to decrease the adhesive force in the tissue below the resistance threshold is established to correlate with its promoter activity. The coincidence of tissue specificity of both effects and active doses of substances is observed.

Animals↗
PubMed1989

[Effect of tissue-specific proliferation inhibitors on the level of mitotic activity and cell adhesion in disordered innervation].

In the work there was studied the influence of hepatic chalones on the level of mitotic activity and on the degree of adhesion of hepatocytes after the violation of parasympathetic and sympathetic innervation under the physiological conditions of liver function and in regenerating organ. Some definite regularities were revealed in the change of the power of linkage among the cells of liver parenchyma after the disturbance of its innervation and chalones affected. Significant differences in the effect of the influence of tissue inhibitors of proliferation on the process of regeneration in liver, which has intact or disturbed innervation were discovered. Particularly one can underline the effect of the loss of hepatocytes sensitivity to chalones in vagotomized liver.

Animals↗
PubMed1988

[Disturbance of the mechanical integration of cells in tissues in the occurrence of spontaneous hepatomas and lung adenomas in mice].

The force (F) and coefficient of stability (Cst) of cell cohesion were measured in the liver parenchyma from CBA mice and in alveolar epithelium of the lung from A mice (genetically susceptible to spontaneous tumours) aged 1 to 13 months. Coefficients of F and Cst magnitude variation increase, while those of mean Cst decrease in animals aged 9 months in the both tissues. In spontaneous tumours F and Cst decrease more considerably. In the nontumour tissue near the tumours the Cst coefficient increases again, but the F coefficient remains low. The author considers that a decrease in the mechanical cell integration of the tissue is necessarily involved into the process of blastomogenesis and that a decrease of F stimulates the tumour promotion.

Adenoma↗
PubMed1982

[Effect of contactin from the lung on the cellular proliferative activity of the alveolar wall].

The influence of contactine from rat lung on DNA synthesis in pulmonary alveolar tissue of A mice was studied in vivo. Two-fold decrease in the total index of pulmonary tissue cells labeled with 3H-thymidine was observed 7-24 hours following the contactine injection. The inhibition of DNA syntheses was observed at the same concentrations at which a cell cohesion increases. The results presented indicate that the effect of contactine on proliferative activity in vivo may be realized through its influence on cell cohesion.

Animals↗
PubMed1980

[Mechanical properties of the intercellular contacts of hepatocytes of inbred strains of mice and mice predisposed to spontaneous hepatomas].

The adhesiveness of hepatocytes was evaluated in 7 inbred mice and compared to the reported data on the incidence of spontaneous hepatomas. The adhesiveness was shown to be significantly less in mice predisposed to spontaneous hepatomas as compared to more resistant species. Electron microscopy revealed the presence of little and highly adhesive areas (HAA) in nonspecialized regions of hepatocytic contacts, this presence being shown by elevated (20-30 mm Hg) hydrostatic pressure in the liver blood bed. The amount and mechanical strength of HAA was less in CBA mice predisposed to spontaneous hepatomas as compared to resistant C57B1 mice, and correlated with cell adhesiveness.

Age Factors↗
PubMed1978

[Tissue-specific inhibition of DNA synthesis by contactins, factors that possess tissue-specific adhesive activity].

Highly purified factors extracted from the liver and lungs of adult rats, tissue-specifically increasing the stability of intercellular contacts and of cell plasma membranes to mechanical disruption, were found to decrease, in the same manner, the labeling index (LI) in explants of the embryonic tissue of mice. The comparison of the action of these factors on the LI, and on mechanical properties of the tissue has shown that the latter effect is manifested earlier than the former one.

Adhesiveness↗
PubMed1977

[Effect of the tissue-specific lung adhesive factor on the urethane induction of pulmonary adenomas in mice].

The effect of adhesive factor (AF), urethane and their combination on the mechanical properties of lung tissue (this effect was assessed by the nuclei isolation during a standard dispersion procedure) and on adenoma induction was studied. As shown, the AF doses eliminating the primary action of urethane on the mechanical properties of the tissue significantly decreased the incidence of adenomas. High AF doses producing a contrary effect on the mechanical properties of the tissue failed to eliminate the primary effect of urethane and did not decrease the number of adenomas induced by urethane.

Adenoma↗
PubMed1975

[Tissue-specific depression of DNA synthesis by calcium salt-free liver and lung extracts that are able to increase the stability of cell linkage in the tissue].

The macromolecular fraction of Ca-free salt extracts (Ca-FSE) removed from lungs and liver of adult rats, mice and fishes inhibits DNA synthesis in the embryonic tissue. The effect of Ca-FSE is tissue-specific rather than species-specific. Ca-FSE was earlier reported to increase with the same specificity the tissue stability to mechanical disruption. A concept is proposed that the tissue-specific adhesive factor may play the role of G1-chalone in epithelial tissue.

Animals↗