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Biomedical subjects

E A Moser

Publications and source records attributed to E A Moser.

At least 19 recordsLinked to original sources
PubMed1998

Combined FDG and [F-18]fluoride whole-body PET: a feasible two-in-one approach to cancer imaging?

PURPOSE: To evaluate the diagnostic usefulness of the combined application of 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG; for the evaluation of soft tissue) and [F-18]fluoride (for the evaluation of the skeleton) in positron emission tomography (PET) of cancer. MATERIALS AND METHODS: Sixty consecutive patients (23 women, 37 men; mean age +/- SD, 51 years +/- 14; age range, 13-76 years) were entered into this prospective study. Thirty patients underwent only FDG PET. Thirty patients underwent combined FDG and fluoride PET. The PET findings were correlated with the findings of other imaging modalities. Interobserver agreement for the anatomic lesion localization was calculated with the use of the kappa statistic. RESULTS: All 30 combined FDG and fluoride studies yielded high-quality whole-body images. PET findings correlated with other imaging findings in 54 (78%) of 69 lesions in the control group and with 64 (88%) of 73 lesions in the combined group. Interobserver agreement in the control group was 0.74; it was 0.95 in the combined group. CONCLUSION: Combined FDG and fluoride PET is an advanced metabolic imaging approach for the evaluation of cancer.

Adolescent↗
PubMed1993

Correlation of ultrasound and renal scintigraphy in children with unilateral hydronephrosis in primary workup.

Ultrasound accurately detects hydronephrosis in infants and children, while nuclear medicine techniques quantify relative renal function in addition to characterizing the urodynamic relevance of hydronephrosis. This prospective study was undertaken to examine the relationship between ultrasound morphological findings and relative renal function, quantified with dynamic 99mtechnetium mercaptotriacetylglycine imaging, in the initial diagnostic workup of children with unilateral hydronephrosis. The ultrasound grade of hydronephrosis and relative renal function ipsilateral to the hydronephrosis were inversely related, indicating that with more severe hydronephrosis ultrasound fails to estimate the potential reduction of relative kidney function. Because renal function is not necessarily affected by hydronephrosis, renal scintigraphy is indicated to assess the functional status of hydronephrotic kidneys.

Child↗
PubMed1993

[Whole body positron emission tomography in breast cancer].

The value of whole body positron emission tomography using F-18 2-deoxy-2-fluoro-d-glucose in primary work-up and follow-up was prospectively evaluated in 37 patients with primary or metastatic breast cancer. From 20 primary breast masses 15 from 16 malignant and 4 from 4 benign lesions confirmed by biopsy, were detected. In 3 out of 21 patients in correlation to morphologic imaging, respectively biopsy, no metastatic disease was not identified. Generally speaking, whole body positron emission tomography appears to be a suitable diagnostic staging tool in breast cancer.

Adenocarcinoma↗
PubMed1992

Primary osteosarcoma of the thyroid gland.

Primary extraosseous osteosarcoma of the thyroid gland is a rare tumor which is associated with a poor prognosis. In this report, we discuss such a tumor and its recurrence in a 78-yr-old female with multinodular goiter, focusing on the imaging evaluation of this unusual tumor.

Aged↗
PubMed1989

Brain morphology and regional cerebral blood flow in anorexia nervosa.

Cranial computed tomography (CT) was performed in 12 patients with anorexia nervosa, revealing that the majority of the patients displayed ventricular dilatation and/or sulcal widening. In addition, regional cerebral blood flow (rCBF) was measured at admission and once again after weight gain, using xenon-133 dynamic single-photon emission tomography (dSPECT). The mean flow rates assessed at the first examination did not significantly differ from those assessed at the second examination and from those of a control group. There was a significant inverse relationship between the size of the cerebrospinal fluid spaces and the cerebral blood flow in the anorectics; a decrease in ventricular size after weight gain was associated with an increase in cerebral blood flow in this area. This finding, however, has to be interpreted with caution, as partial volume effects render the flow rates ambiguous in brain areas, which, in addition to neuronal tissue, also include ventricular and sulcal structures.

Adolescent↗
PubMed1987

Laminitis and decreased milk production in first-lactation cows improperly fed a dairy ration.

First-lactation cows that were improperly fed a grain ration developed chronic, nonsuppurative laminitis, resulting in profound lameness in all 4 limbs, thin body condition, and poor milk production. Results of ration analysis indicated that the cows were receiving 10% to 40% more energy than that recommended by the National Research Council. The following management changes were instituted for first-lactation cows: the absolute amount of concentrate offered was decreased by 10% to 25% (depending on each cow's milk production), the rate of increase in concentrate fed was lessened to achieve maximal intake in 21 days, feed was made available more frequently and in smaller amounts during the day, sequence feeding was implemented, forage was provided before grain when possible, and sodium bicarbonate (1%, on a dry-weight basis) and fat (5%, on a dry-weight basis) were added to the grain mix. These management changes normalized rumen fermentation, and the clinical problems did not develop in the 20 subsequently fresh heifers. Therefore, the ration should be analyzed when first-lactation cows begin developing lameness and poor milk production.

Animal Feed↗
PubMed1984

[Relative determination of hemisphere perfusion and hemisphere circulation. A comparison of the results of computer-assisted radionuclide angiography and dynamic single photon emission CT in patients with unilateral cerebrovascular disease].

Ratios of interhemispherical perfusion and blood flow were derived from 72 patients with reversible (TIA, PRIND) or irreversible (completed stroke) ischemic neurologic deficits. Differences from normal mean values (right-to-left: 1.00) were determined by employing CARNA with 99mTc-DTPA (perfusion) or DSPECT with 133Xe-gas (blood flow in ml/100 g/min). These differences were constantly higher for CARNA than for DSPECT. Such an excess for CARNA values was interpreted as the delay portion within the CARNA results, which increased from completed stroke (33% delay) to TIA (62% delay). The complement, i.e. the low flow portion, decreased in this sequence. Separation of CARNA values into delay and flow portions provides further information on the individual severity of cerebrovascular disease by employing a simple nuclear procedure. Moreover, it complements morphological findings from radiographic angiography and transmission CT.

Adolescent↗
PubMed1984

Dynamic SPECT with Xe-133: regional cerebral blood flow in patients with unilateral cerebrovascular disease: concise communication.

To validate xenon-133 dynamic single photon emission tomography (SPECT) clinically, 74 patients were examined. Strictly unilateral cerebrovascular disease was confirmed in 47 patients by clinical history and by transmission computerized tomography (TCT) and contrast angiography. Twenty-seven were excluded, considered normal. SPECT flow maps were evaluated visually (against TCT) or by automated region of interest (ROI) techniques (12 areas per slice) to measure area flow (AF) (ml/100 g-min) and interhemispherical area flow ratios (AR). These were compared with normal values. Minimum AF in affected hemisphere decreased, and AR-to-normal difference increased, with the severity of the disease. Visually, low-flow areas were detected twice as frequently in SPECT as areas of low density of TCT. In reversible episodes, sensitivity of AF alone ws significantly below the sensitivity of combined evaluation of flow and ratio.

Adult↗
PubMed1983

[The iodine 131-hippurate clearance for the determination of the nephrotoxic effect of cis-dichlorodiamino-platin (II) (cis-platin, cis-DDP)].

In 25 patients, who received repeated doses of cis-DDP, we determined iodo-131-hippurate-clearance, creatinine clearance and serum creatinine to assess the nephrotoxic effect induced by cis-DDP. A highly significant decrease in the iodo-131-hippurate-clearance was found between the first and the following cycles. There was no significant change in serum creatinine and creatinine clearance however. The radio-hippurate-clearance showed a clinically not important reduction during several cytotoxic courses in 15/25 patients (60%). A clinically relevant impairment of the radio-hippurate-clearance occurred in 8/25 patients (32%), mainly before the third and fifth cytotoxic cycle. In two patients this clearance did not alter or was even rising. In 12 cases a diminuation of the iodo-131-hippurate-clearance was observed, which in only 5 cases correlated to a decreased creatinine clearance and in only two cases to an elevated serum creatinine. Therefore, we consider neither creatinine nor creatinine clearance nor the combination of both parameters to be appropriate to assess tubular nephropathy induced by cis-DDP. Radio-hippurate-clearance should play a superior role deciding on treatment stop or dose reduction of cis-DDP. The regression of cis-DDP-induced nephropathy was not evaluated.

Adult↗
PubMed1983

[133Xe-DSPECT (Dynamic Single Photon Emission CT). Results of a new noninvasive method for measuring regional cerebral blood flow (rCBF). Comparison with cranial angiography and transmission CT].

133Xenon-DSPECT provides measurement of regional cerebral blood flow (rCBF in ml/100 g/min) during and after inhalation of 133Xe gas. The result is displayed as a flow map of three transaxial slices. ROI divide a slice into 12 areas (SA) computing flow values (FSA). The results in 36 patients with cranial vascular disease are presented in comparison to 12 "normals". In all patients, FSA in the diseased hemisphere were found to be below the standard range of normals. Related to number of SA, this was true in completed stroke (bilateral) in 55% or (unilateral) in 14%, in PRIND in 5% of SA and in TIA in 7%. The absolute flow values did not decrease with the severeness of the disease, presumably depending on patient's age. There were more (p less than 0,005) SA found with decreased rCBF (21%) than areas with low density in T-CT (10%). Since unilateral cerebrovascular findings presented also bilateral reduced FSA, the validity of the method lies in the calculation of flow values, which significantly adds to the results of imaging.

Cerebral Angiography↗
PubMed1983

[Whole-body retention of 99mTc-methylene diphosphonate in skeletal diseases].

The 24 h-whole-body retention (WBR), determined by a whole-body counter, may be used to quantify exactly bone seeking properties of a radiopharmaceutical. The 24h-WBR of 99mTc-methylene-diphosphonate was determined in 200 patients and was found to be independent of kidney function if this function was normal or only slightly diminished. The 24h-WBR was slightly dependent on age since it decreased up to 20 years of age, reaching a minimum at 20-25 years, and then increased with increasing age. Normal values of 24h-WBR for individuals of more than 20 years of age were 31.8 +/- 5% of injected dose. Not more than two focal accumulations, i.e. skeletal metastases, failed to elevate the 24h-WBR significantly (p less than 0.1). However, a highly significant (p less than 0.001) difference to normals was found in patients with multiple metastases (24h-WBR: 38.2 +/- 7%), with diffuse osseous involvement as in primary hyperparathyroidism (24h-WBR: 49 +/- 11.7%, p less than 0.001) or with osteoporosis (24h-WBR: 45%). The 24h-WBR was found to be very sensitive in grading diffuse osseous involvement. This was shown in single-tumor patients by follow-up as the 24h-WBR in addition to bone scans was useful to describe progression or remission. Moreover, the 24h-WBR correlated closely with results of bone marrow biopsies in a small group of patients with malignancies of the lymphoreticular system.

Adolescent↗
PubMed1982

A comparison of bone imaging with Tc-99m DPD and Tc-99m MDP: concise communication.

Bone to soft tissue (ST) ratios for both high-uptake bone (sacrum) and low-uptake bone (femoral diaphysis) were obtained with a derivative of phosphonic acid, TC-99m 2,3-dicarboxypropane-1, 1-diphosphonate (DPD), in 26 normal subjects and 177 patients with malignant disease but without metastases. Tests were run 2 hr after tracer injection. Similar ratios were obtained with Tc-99m methylene diphosphonate (MDP) in 220 normal subjects and 451 patients. With MDP, the influence of incubation time (5-10 min in 416 cases, 45 min in 185 cases) on these ratios was determined. DPD was superior to MDP for both ratios. With MDP, prolonged incubation time yielded significantly enhanced ratios; however, the ratios for the DPD were still higher. With either agent and preparation, sacrum-to-ST ratios decreased with increasing subject age, and in patients with malignant disease the ratios tended to be higher than those obtained from normals.

Adult↗
PubMed1981

Dietary fat effects on blood insulin, glucose utilization, and milk protein content of lactating cows.

Relationships among dietary fat, glucose and insulin in blood plasma, and milk protein were investigated to determine mechanisms by which high fat diets depress milk protein percentage of lactating cows. Glucose clearance, determined by intravenous glucose infusion tolerance tests, of cows fed high fat diets was lower and insulin release higher than of control cows. Negative relationship between glucose utilization rate and insulin release was linear (correlation -.85), suggesting that fat feeding induced insulin resistance. Feeding lipid in a protected supplement did not change production of milk or milk protein but depressed milk protein percentage and increased quantity and concentration of milk fat. Concentrations of total lipids in blood plasma were increased whereas glucose and insulin were reduced by protected lipid supplement. Dietary fat may impair amino acid transport into the mammary gland and milk protein synthesis by inducing insulin resistance.

Animals↗