Biomedical subjects
Publications and source records attributed to E A Odintsova.
Pronounced ultrastructural changes in vessels and mast cells were observed in duodenal lamina propria of Wistar rats 1 year after single whole-body gamma-irradiation in a dose of 7.5 Gy. Inhibition of adrenocortical function with methopyrone reduced structural damage and improved animal survival.
We propose classification of duodenal endocrine cells of intact rats based on ultrastructural signs of secretory granules and subdivided these cells into 10 basic types. The effect of long-term irradiation in a total dose of 2.5 Gy on ultrastructural organization of duodenal apudocytes was studied. Irradiation induced nonspecific changes of cell organelles in apudocytes. Differences in the ultrastructural disorganization were detected between different types of apudocyte populations and between different types of endocrine cells. Under conditions of adaptation to radiation apudocytes released the secretory product not only through molecular extrusion and exocytosis, but also via degranulation.
Age-specific ultrastructural postradiation changes in the main types of duodenal endocrine cells (apudocytes) were studied in rats 6 and 12 months after single whole-body irradiation in doses of 7 and 7.5 Gy. Ultrastructural disorganization of different severity was detected, which depended on apudocyte type and term postradiation. Degranulation was the basic mechanism of hormone secretion in delayed periods after the exposure.
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