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Biomedical subjects

E A Petrova

Publications and source records attributed to E A Petrova.

At least 19 recordsLinked to original sources
PubMed1991

[Prevention of postoperative infectious complications with suture materials containing gentamicin].

Sutural materials containing antibiotics such as gentamicin and tetracycline were studied on dogs with respect to the action on development of inflammation reactions after operations on the large intestine. It was shown that the antibacterial surgical threads had a prophylactic action and inhibited infection development. There was noted a significant advantage of the threads over the control ones not containing the antibiotics. The inflammatory reactions were less intensive and of shorter duration. The terms of onset and completion of the reparation also markedly shortened.

Animals↗
PubMed1989

[The content of cholylglycine in the blood serum in cholelithiasis during treatment with litholytic preparations of bile acids].

Liver function has been assessed on the basis of radioimmunoassays of the primary conjugated cholic acid, cholylglycine, in the blood sera of cholelithiasis patients treated with cheno- and ursodeoxycholic acid drugs for a long time. The findings indicate that the blood serum cholylglycine levels may be regarded, among other things, as a prognostic criterion of the efficacy of cholelithiasis therapy with bile acid preparations for litholysis.

Adult↗
PubMed1989

[Bile excretion system in endogenous hypercorticism syndrome].

Bile excretion and biochemical properties of bile were investigated in 86 patients with the endogenic hypercorticism syndrome, 78 patients with the Itsenko-Cushing disease and in 8 patients with corticosteroma. A considerable incidence of functional and organic biliary disorders was demonstrated. Changes in cholecyst contractility were recorded in 54.6% of the patients, with hypermotor dyskinesia (36.4%) prevailing. An excess of endogenic corticosteroids was frequently accompanied by a hypotonus of Oddi's sphincter (65.6%) or Lutkens' sphincter (67.2%). Chronic (stoneless) cholecystitis was diagnosed in 70.9% of the patients, cholelithiasis, in 16.3%, and cholecyst cholesterosis, in 3.5%. Adrenocortical hyperfunction was associated with natural changes in biochemical composition of the bile, such as excessive cholesterol and a relative deficiency of cholic acid and phospholipids which might be conducive to cholelithiasis. High incidence of biliary disturbances and their pattern should be taken into account in the treatment of patients with hypercorticism.

Adolescent↗
PubMedDate not supplied

[Experimental research on the effect of ultraviolet irradiation on the phosphorus-calcium metabolic status].

The influence of vitamin D and ultraviolet irradiation (UVI), used for prevention of vitamin D deficiency, on the state of phosphoric-calcium metabolism was studied in experiments on rats. It has been shown that daily injections of 1-5 IU of vitamin D, and UVI in biodoses from 1/8 to 1/4 promote the maintainance of the normal level of phosphoric-calcium metabolism. When UVI was applied according to the widely used "basic scheme" (in biodoses from 1/4 to 2 1/2) the following anomalies were recorded: a three-fold increase of 25-ON-D3 concentration in the blood plasma, hyperphosphatemia, a tendency to hypercalcemia. The use of higher doses of UVI led to a further increase of 25-OH-D3 level, hypophosphatemia, hypercalcemia, kidney and heart calcification. The data obtained have evidenced a possibility of vitamin D intoxication during UVI.

Animals↗
PubMedDate not supplied

[Toxic action of ergocalciferol in strontium rickets].

Tests conducted on albino rats of the Wistar line demonstrated that introduction of large doses of ergocalciferol (vitamin D2) to animals kept on a strontium-rich diet exhibiting signs of rickets brings about the development in them of specific manifestations of the D-vitamin activity, viz. rising level of calcium, strontium and inorganic phosphorus in the blood serum, lowering of the alkaline phosphatase activity and a greater degree of the soft tissues calcification.

Animals↗
PubMedDate not supplied

[Esophageal lesions in Cushing's syndrome and corticosteroma].

The state of the esophagus was studied in 60 patients with endogenous hypercorticism (2 with corticosteroma, 58 with Icenko-Cushing disease). The purpose was to reveal the nature and frequency of esophageal lesions and peculiarities of their clinical symptoms. X-ray and endoscopic methods were used. Functional and organic esophageal changes were shown to be rather common in patients with excess of body glucocorticoids: hypomotor dyskinesia was noted in 27% of the patients, cardial insufficiency in 13%, cardial hernia of the esophageal orifice of the diaphragm in 28%, reflux-esophagitis in 43%. Cardial hernia and esophagitis in such patients are often characterized by weak clinical symptoms masked by other signs of severe endocrine pathology. They can be also symptomless making their early diagnosis difficult. However these esophageal diseases are fraught with danger and life threatening complications: ulcerations, perforations, esophageal hemorrhages aggravating a course of the main disease. These patients need appropriate therapy to avoid complications.

Adolescent↗