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Biomedical subjects

E A Smirnov

Publications and source records attributed to E A Smirnov.

At least 19 recordsLinked to original sources
PubMed1990

[Primary disability due to tuberculosis].

The social and clinical background of 1,043 tuberculosis patients newly recognized as disabled was studied. A complex study of the interrelation between tuberculosis-induced disability and medical and social factors was undertaken. Ineffective treatment proved to be the leading cause of disability, associating with untimely detection of the disease in 19.4% of the cases, irregular chemotherapy in 51.2%, concurrent chronic alcohol abuse in 31.4% as well as with insufficient use of surgical interventions and disruptions in the treatment continuity at its different stages. An important role in establishing the disability belongs to a low qualification level of the patients, their ++counter-indicated occupational conditions and the associated difficulties in their employment. A possible drop in the disability extent depends upon a number of issues dealing with preventive, diagnostic, therapeutic and social activities.

Adult↗
PubMed1989

[Patho-anatomic changes in rotaviral gastroenteritis in children].

Two children (a 6-month-old girl and a 9-month boy) died from Rotavirus gastroenteritis as evidenced by virological, electron microscopic, and immune fluorescence studies of intestinal tissue. Histological and morphometric examinations of the small intestine revealed acute diffuse enteritis with enlarged and shortened villi, infiltration of intrinsic plates with lymphocytes, plasma cells and macrophages, enhanced mitotic activity of epitheliocytes and their increased lymphocyte-induced infiltration. The hepatic tissue showed central lobular fatty infiltration. The above changes should be regarded as manifestations of Rotavirus infection. Pneumonia detected in one of the children had been caused by influenza infection.

Gastroenteritis↗
PubMed1980

[Morphological characteristics of the phase and staging in cancer development].

According to the biopsy (10000 tumors) and autopsy materials cancer in its development occurs in the following stages: background lesions, precancer, preinvasive cancer (Ca in situ) and invasive cancer. Background lesions contribute to and precede the development of cancer, the former are associated with the proliferation of epithelial cells with their preserved differentiation. In precancer--excessive proliferation of epithelial cells with the formation of papillary outgrowths, pseudomultistratified cells without their anaplasia. Preinvasive cancer (Ca in situ) is referred to as a zero stage of cancer (according to WHO classification). Background lesions in 10-20% progress to cancer, precancer in 20-30%--to preinvasive cancer (Ca in situ), and preinvasive cancer develops into invasive cancer in 30-60% of cases. With background [corrected] lesions cancer is noted in 2-3%, in precancer--in 3-6%. An early diagnosis of cancer is possible with the recognition of preinvasive cancer (Ca in situ) and microinvasive cancer, yielding most favourable clinical issues.

Carcinoma in Situ↗
PubMed1978

[Lung cancer in different chronic lung diseases].

The studies performed have indicated that nearly in 50% of cases lung cancer is associated with different chronic lesions of the lung: chronic purulent bronchitis, tuberculosis, chronic pneumonia, pulmonary emphysema and diffuse pneumosclerosis, and these provide favourable conditions for epithelial metaplasia of the bronchi, bronchioli and alveoli with subsequent cell atypism and development of lung cancer.

Chronic Disease↗
PubMed1978

[Malignant mesothelioma of the pericardium].

An observation of malignant mesothelioma of the pericardium is described. The tumour grew as papillomatous formations and thick plaques lining the inner surface of the pericardium with transition to the epicardium and the development of massive hemorrhagic pericarditis. The mixed nodular-plate form is histological close to adenocarcinoma. There were metastases in the pleura, paratracheal and posterior mediastinal lymph nodes. Clinically the disease ran a course with angina pectoris and simulated idiopathic myocarditis not confirmed histologically.

Diagnosis, Differential↗
PubMed1977

[Neoplastic alveolitis complicating chronic pneumonia].

The author describes two observations on cancerous alveolitis and bronchiolitis developed in the foci of chronic (interstitial) pneumonia under squamous metaplasia and anaplasia of epithelial cells of alveoli and bronchioli. Two cases were diagnosed by roentgenologists, one case was found pathoanatomically; in the first two cases the patients died due to grave hypoxia and cardiopulmonary insufficiency, in the third case-due to encephalomalacia in ischemic brain disease. Cancerous alveolitis and bronchiolitis made 2.4% to all lung cancer, the disease shows an acute course, the duration of the lesion-4-6-months.

Carcinoma, Squamous Cell↗
PubMed1976

[Lung cancer in chronic inflammatory processes of the bronchi and pulmonary tissue].

An attempt was made to determine the frequency of lung cancer occurrence in different inflammatory processes in the bronchi and pulmonary tissue. 100 cases of lung cancer were studied according to case reports and autopsy finding, the main tumor node and metastases were explored histologically. The data obtained indicated that in 2.2% of cases the development of cancer was preceded by influenza with residual phenomenon such as purulent bronchitis or pneumonia, in 2.3% of cases cancer occurrence was found to be dependent on chronic pneumonia. In 12.1% of cases cancer has arisen in fibrous-focal or cirrhotic tuberculosis with the presence of old caverns; in 14.7% of cases its development was related with pneumosclerosis and bronchiectases, and in 17.8% of cases it developed against the background of purulent bronchitis.

Adenocarcinoma↗
PubMed1975

[Development of cancer of the corpus uteri against a background of adenomatosis].

An attempt was made to differentiate various types of development of corpus uteri adenomatosis in the clinico-morphological aspect. Three forms of adenomatosis were differentiated: focal, diffuse and malignant adenomatosis. Studies of curetting specimens from the uterine body revealed adenomatosis in 3.4% of cases. Malignant adenoma of the corpus uteri was defined by the author as a malignantly transformed adenomatosis. Mos frequently adenomatosis developed at the age of 35-55 years, its transition to "adenomatous cancer" was noted in 30-40% of cases and more often in females aged 55-77 years.

Adult↗