Effects of long-term catheter implantation on the contractile and histological properties of the canine bladder.
In beagles, a bladder catheter was surgically implanted and subvesical obstruction was artificially introduced. After 3 months a striking reduction in detrusor contractility measured in vitro was observed, which was associated with a presumptive reduction in the concentration of acetylcholinesterase in the muscle cells and a probable reduction in the mean cell size. In this model the contribution of the catheter to the changes is greater than that of the subvesical obstruction.