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Biomedical subjects

E A Totrova

Publications and source records attributed to E A Totrova.

11 recordsLinked to original sources
PubMed1978

[Effect of thyroidectomy on the water-eliminating function of the kidneys in puppies].

Removal of the thyroid gland in puppies in the early postnatal period (10--20 days) suppressed the hemodynamics and the glomerular filtration, increased concentration of urine in the tubules of the kidney and reduced spontaneous diuresis. Two months after the operation, a progressive disturbance of the osmotic concentration of urine occurred, and the diuresis increased. Thyroidectomized puppies at different age are unable to react to water deprivation, to develop osmotic diuresis; the elimination of water load is lesioned. In the first 6 months the introduced water is retained in the organism. The thyroid hormones are essential for the water elimination and concentrating functions of the kidney, for its adequate hemodynamics.

Age Factors↗
PubMedDate not supplied

[Electrolyte, water and hexosamine content of animal tissue in hypothyroidism and thyrotoxicosis of different degrees of severity].

Sodium and water content progressively grows in the skeletal muscles and skin of thyroidectomized dogs in the course of diuresis fall and in rats under thyroid gland chemical blockade. The skin hexosoamine concentration, influencing water retention depending on hypothyrosis duration, increases. The potassium content in the dog muscles and skin as well as in the rat muscles is lowered, being unchanged in the rat skin. In experimental thyrotoxicosis of dogs during polyuria the sodium and water content in the muscles and skin is reduced after thyroxin administration, the potassium level remaining unchanged. In latter pathology (oliguria development) sodium and water retention in the tissues is observed, the potassium level being decreased. Similar changes are seen in rats following thyroxin injection.

Animals↗
PubMedDate not supplied

[Mechanism of the effect of thyroid hormones on renal function].

Chronic experiments were conducted on 32 dogs; it was shown that thyroxin (T4) administered in a dose of 50 micrograms/kg into the renal artery through the implanted catheter produced a primary action on the tubular apparatus of the kidney inducing natriuresis from the first minutes in the experimental kidney. High T4 doses (200 micrograms/kg) activated renal hemodynamics as well. Natriuretic effect of T4 was not eliminated by alpha- and beta-adrenoblocker. Triiodthyronine (T3) manifested a direct action on the vascular apparatus of the kidney from the first minutes. Its activating effect on hemodynamics (in the same way as that of T4) is eliminated or diminished by beta-adrenoblockers.

Animals↗