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E A Tsverbaum

Publications and source records attributed to E A Tsverbaum.

3 recordsLinked to original sources
PubMed1987

[Decrease in the concentration of leukocyte acetylation coenzyme associated with vitamin precursor deficiency in patients with alcoholic delirium].

Sixty-three patients with the typical variant of delirium tremens were examined. The results showed a marked reduction (by 8.7 times) in levels of coenzyme A (CoA) in leukocytes, which was indicative of deficiency of the coenzymic form of pantothenic acid (PA). Changes in CoA concentrations in leukocytes observed at the height of psychosis in patients with alcoholic delirium as compared to other parameters of PA metabolism have great significance for the assessment of vitamin metabolism. PA deficiency was more expressed in cases of long-standing and massive alcoholization which induces an earlier development of psychosis. CoA levels in leukocytes may be used as a parameter of detoxication processes in patients with delirium tremens. The data obtained are considered as indication for administration of PA drugs in combined detoxifying therapy of alcoholic psychoses.

Adult↗
PubMedDate not supplied

[Pantothenic acid biotransformation in human vitamin deficiency].

Content of CoA and pantothenic acid in leukocytes as well as excretion of the vitamin derivatives, estimated by microbiological procedure, with urine with 6 and 24 hrs after administration per os or intramuscularly of 200 mg calcium pantothenate were studied in 42 donors and 25 patients with chronic alcoholism. In all the cases content of CoA of the pantothenate metabolites were increased in leukocytes within 6 hrs after the vitamin loading. Excretion of pantothenic acid and its derivatives with urine was increased for a short time in healthy persons after loading, however its total content maintained similar to normal values within 24 hrs. In the patients with chronic alcoholism the increase in concentrations of the components studied in leukocytes was accompanied by a distinct increase in excretion of the vitamin with urine within 24 hrs.

Adult↗