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Biomedical subjects

E Abdel-Salam

Publications and source records attributed to E Abdel-Salam.

At least 19 recordsLinked to original sources
PubMed1986

Association of HLA class I antigens (A1, B5, B8 and CW2) with disease manifestations and infection in human schistosomiasis mansoni in Egypt.

The present study was designed to examine the possible association of HLA antigens and schistosomal hepatosplenomegaly and colonic polyposis in a large number of patients and controls. The results show that hepatosplenomegaly was significantly associated with the presence of two HLA antigens: HLA-A1 and B5; and colonic polyposis to HLA-B5 and B8. Furthermore, asymptomatic infection was significantly seen more in subjects with CW2. These results point to possible gentic factors controlling the pathogenesis of disease and susceptibility to infection in human schistosomiasis.

Adolescent↗
PubMed1986

Discrepancies in outcome of a control program for schistosomiasis haematobia in Fayoum governorate, Egypt.

A large scale mollusciciding and chemotherapy program in the Fayoum area of Egypt was reported to have decreased prevalence of schistosomiasis haematobia from 46% to 7% in approximately 12 years. In order to assess the uniformity of results reported, we have studied the prevalence and intensity of urinary tract disease in a random sample of children aged 6 months-12 years in 3 areas selected on the basis of distance from the main canal supplying Fayoum and where mollusciciding was applied. Only 1 location near the main canal showed low prevalence (2.2%), while in the other 2 areas prevalence was 75.3% and 61.3%. Intensity of infection and disease were significantly more in the latter 2 locations. Following chemotherapy, a marked reduction in prevalence and intensity of infection and reversal of pathology was seen. Since the reported favorable results of the Fayoum project were used to implement a wider control program in southern Egypt, an independent assessment must be included in future plans.

Child↗
PubMed1984

Immunofluorescent analysis of renal biopsies in uncomplicated Schistosoma haematobium infections in children.

Renal biopsies were studied by light and immunofluorescent microscopy in 13 young individuals with uncomplicated Schistosoma haematobium infections. Slight mesangial cell proliferation and matrix increase were found in three biopsies and focal interstitial inflammatory infiltrates were noted in six. However extensive IgG (nine cases) and IgM (seven cases) granular deposits were found in the mesangial areas. C3 was found in only three of these cases. Clq, fibrinogen, IgA and IgE were not found deposited except for one case with IgE. Schistosome antigen was identified in mesangial areas in four biopsies after acid treatment of the sections. It appears the immune complexes are deposited consistently in the renal glomeruli in S. haematobium infections but their role in inducing clinical renal disease is minimal.

Biopsy↗
PubMed1981

Cell-mediated immune assay in children with Schistosoma haematobium infection and the effect of niridazole therapy.

Forty-five children with Schistosoma haematobium infections were studied utilizing a whole-blood culture technique to assay lymphocyte blast transformation responses. The mitogenic lectins, phytohaemagglutinin (PHA) and pokeweek mitogen (PWM), and heterologous schistosomal antigens from adult worms and eggs were used. Responsiveness to PHA was intact but PWM responses were significantly impaired. Varying responses to schistosomal adult worm antigens were evident. Responses to soluble egg antigens were consistently low. No correlation of lymphocyte transformation responses was evident with egg excretion rates or clinical data. Treatment, primarily with niridazole, resulted in augmented cellular immune responses to PHA, PWM and adult worm antigens and two and eight weeks post-therapy. Anti-egg antigen responses did not significantly change. It was evident that niridazole did not induce cellular immunodepression. The role of schistosome-specific immune modulation is discussed.

Age Factors↗
PubMed1978

Cystoscopic picture of Schistosoma haematobium in Egyptian children correlated to intensity of infection and morbidity.

Cystoscopy was done on 45 children, 5--12 yr old, infected with Schistosoma haematobium. On the basis of urinary egg output, the children were classifed as having mild, moderate, or heavy infection and the cystoscopic picture was correlated with their egg output and with their signs and symptoms. Lesions reported, in descending order of frequency, were: hyperemia, sandy patches, tubercles, ulcers, nodules, and polyps. Multiple schistosomal lesions were present in some patients and the frequency and severity of lesions correlated with the heaviness of infection. Individual variation in the severety of response to S. haematobium was observed.

Child↗
PubMed1977

Prevalence and morbidity of Schistosoma haematobium in Egyptian children. A controlled study.

The prevalence and morbidity of schistosomiasis haematobium were studied in three geographically different villages in Giza governorate in Egypt. The survey included 786 children ranging in age from 6 months to 10 years. There was a marked variation in the prevalence of infection in the three areas, correlated with the socioeconomic standards and sanitary habits, emphasizing their role in the spread of the disease. The youngest child infected was a 14-month-old boy, while the peak of prevalence of infection was in children 8 to 10 years old. The intensity of infection, as indicated by the heaviness of urinary egg output (mean of 3 successive days), was unrelated to the degree of prevalence in the area concerned. On the other hand, such intensity of infection correlated well with the severity of the clinical picture. Immediate skin-test reactivity was related to the intensity of infection, though unreliable as a single diagnostic test in children. Delayed reactivity was less sensitive. Stool examination showed a higher prevalence of other helminthic infections in schistosome-infected children aged 6 to 10 years than in uninfected children. The impact of schistosomiasis on the general health of children as shown by the anthropometric measurements was mild, except in heavily infected children in whom it was significant. The study focused on the overshadowed young age period when infection can be radically cured and even easily avoided. The data point to the importance of considering the intensity of infection, and not the prevalence, in weighing the need for therapy against its toxic effects in children, or in discussing the priorities of treatment in an endemic area.

Age Factors↗