Biomedical subjects
Publications and source records attributed to E Adashi.
Chylous is an extremely unusual cause of leukorrhea. The diagnosis is established by verification of the chylous nature of the discharge, documentation of its uterine origin, and lymphangiographic demonstration of dilated pelvic lymphatics with uterine reflux. Surgical excision of the incompetent lymphatic channels is the treatment of choice.
A large leiomyoma found in a patient with Rokitansky-Kuster-Hauser syndrome 8 years following McIndoe's procedure for the creation of an artificial vagina emphasizes the need for continued long-term gynecologic care of these patients who are theoretically at average risk for the development of myometrial or ovarian neoplasia. The fact that with the syndrome leiomyomata have been reported only three times previously and ovarian malignancy never suggests that these patients are often lost to long-term followup.
A 19-year-old phenotypic female with primary amenorrhea and 45X,0/46X,Y chromosomal mosaicism was found to have asymmetrical gonadal dysgenesis. Her lack of virilization precludes her precise categorization in the current nomenclature of gonadal dysgenesis and she is considered a unique variant of the syndrome of mixed gonadal dysgenesis.
Congenital release thrombocytopathy must be included in the differential diagnosis of bleeding diatheses in women. A review of the coagulation profiles of 7 patients with congenital release thrombocytopathy suggests that more sophisticated platelet aggregation studies must be performed when routine screening procedures fail to determine the cause of a clinically suspected bleeding disorder. Establishing the diagnosis helps to avoid the use of medications which cause an acquired platelet dysfunction, and contributes to adequate prophylaxis against surgical and obstetric hemorrhage.