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Biomedical subjects

E Adorisio

Publications and source records attributed to E Adorisio.

At least 19 recordsLinked to original sources
PubMed2003

Environmental risk factors for type 1 diabetes in Rome and province.

BACKGROUND: In subjects genetically susceptible to type 1 diabetes, exposure to environmental factors during the gestational period, the neonatal period, and the first years of life is thought to play an important role in triggering the immune process leading to beta cell destruction. AIMS: To investigate risk factors for inhabitants of continental Italy. METHODS: A case-control study of 150 type 1 diabetes cases and 750 control subjects (age range 6-18 years) was carried out in Rome and its province, measuring the exposure to environmental risk factors. RESULTS: Three environmental factors were found to occur significantly more in the diabetic group than in the controls. During the mothers' pregnancies, the one risk factor which proved to be higher in diabetics than in controls was maternal infectious disease. During the neonatal period, no risk factors associated with the disease were detected. During early life, eczema and a short duration of breast feeding (less than three months), occurred significantly more in diabetic cases than controls. CONCLUSION: Eczema and breast feeding for less than three months are risk factors for type 1 diabetes in a southern European population. The type, duration, and mode of treatment for infectious diseases during pregnancy need additional investigation as risk factors for type 1 diabetes.

Adolescent↗
PubMed2000

Correlation between decreased expression of mitochondrial F0F1-ATP synthase and low regenerating capability of the liver after partial hepatectomy in hypothyroid rats.

In hypothyroid rats, partial hepatectomy does not induce liver regeneration until 120 h after surgical operation. when, instead, in normal rats a complete recovery of the liver mass, in this interval, is observed. In normal rats, a good efficiency of mitochondrial oxidative phosphorylation is needed as an energy source for liver regeneration (Guerrieri, F. et al., 1995); in hypothyroid rats the efficiency of mitochondrial oxidative phosphorylation is low in the 0-120 h interval after partial hepatectomy. This low efficiency of oxidative phosphorylation appears to be related to a low mitochondrial content of F0F1-ATP synthase, in liver of hypothyroid rats, which does not recover after partial hepatectomy. In the liver of hypothyroid rats, low levels of the nuclear-encoded mitochondrial catalytic betaF1 subunit and of its transcript are observed and they do not increase, as occurs in normal rats, after partial hepatectomy.

Adenosine Triphosphate↗
PubMed1998

Hypothyroidism leads to a decreased expression of mitochondrial F0F1-ATP synthase in rat liver.

In liver mitochondria isolated from hypothyroid rats, the rate of ATP synthesis is lower than in mitochondria from normal rats. Oligomycin-sensitive ATP hydrolase activity and passive proton permeability were significantly lower in submitochondrial particles from hypothyroid rats compared to those isolated from normal rats. In mitochondria from hypothyroid rats, the changes in catalytic activities of F0F1-ATP synthase are accompanied by a decrease in the amount of immunodetected beta-F1, F0 1-PVP, and OSCP subunits of the complex. Northern blot hybridization shows a decrease in the relative cytosolic content of mRNA for beta-F1 subunit in liver of hypothyroid rats. Administration of 3,5,3'-triodo-L-thyronine to the hypothyroid rats tends to remedy the functional and structural defects of F0F1-ATP synthase observed in the hypothyroid rats. The results obtained indicate that hypothyroidism leads to a decreased expression of F0F1-ATP synthase complex in liver mitochondria and this contributes to the decrease of the efficiency of oxidative phosphorylation.

Animals↗
PubMed1996

Chlamydia trachomatis-associated respiratory disease in the very early neonatal period.

Of 103 preterm neonates admitted consecutively to the neonatal intensive care unit soon after birth for respiratory distress, 8 were found to be Chlamydia trachomatis-positive as early as within the first 24 h of life. All these patients required mechanical ventilation and supplemental oxygen. Six infants had evidence on chest radiographs of hyaline membrane disease, one of pneumonia, and one of slight bilateral parenchymal changes. Our results suggest that the presence of C. trachomatis in preterm infants with neonatal respiratory distress is probably not an infrequent event.

Chlamydia Infections↗
PubMed1996

A 5-year (1989-1993) prospective study of the incidence of IDDM in Rome and the Lazio region in the age-group 0-14 years.

OBJECTIVE: To provide data on the incidence of IDDM in Rome and the Lazio region evaluated prospectively from 1989 to 1993 for a total of > 5 million subjects younger than 15 years. RESEARCH DESIGN AND METHODS: All patients with newly discovered IDDM diagnosed between 1 January 1989 and 31 December 1993 among residents in Rome and its region were recorded. Primary ascertainment was based in diabetes clinics and specialized hospitals in the region, whereas the secondary independent source was taken from the archives of the region where patients are registered to obtain exemption from paying for medications. RESULTS: We identified 330 new patients with a degree of ascertainment of 85%. Overall the incidence rate of the disease was 7.9 per 100,000 per year (95% CI 7.1-8.8). The incidence was higher in the 5- to 9-year-old age-group (10.4 per 100,000) and in winter (36.2%). The cumulative risk for the disease is on the order of 1.18 per 1,000 subjects < 15 years of age. No significant differences in incidence were observed between boys and girls. There were 14 instances of coma at diagnosis (4.3%), but hyperglycemia without ketonuria was diagnosed in 35% of patients, suggesting an early diagnosis. DISCUSSION: Compared with the other continental Italian regions for which data are available for a single year, the IDDM incidence rate in Rome is similar. We conclude that the IDDM incidence rate in Rome and its region is comparable to that in other Southern European countries and remained stable over the 5-year observation period.

Adolescent↗
PubMed1996

[A seroepidemiological study of brucellosis infection in the province of Campobasso].

These research regarded a seroepidemiological study of brucellosis in the Campobasso province. The results related to 204 subjects (96 males and 108 females) pointed out the 17.15% of subjects were positive for antibodies anti-Brucella, 28.6% of these were positive for Br. melitensis. The results agree with the data of the literature.

Antibodies, Bacterial↗
PubMed1996

[Prevalence of Toxoplasma gondii infections in groups of individuals in Rome and its environment].

This study was aimed out to point out the prevalence of Toxoplasma gondii infections in Roma and in the province. The results pointed out that the percentage of antibodies positivity has been 45% this prevalence was the same of the prevalence reported by other authors in Italy. The presence of a lot of women without anti-Toxoplasma gondii antibodies shows that is necessary to continue the control of the young women especially at the beginning of the pregnancy.

Animals↗
PubMed1980

Serological survey of toxoplasmosis in Somalia.

Of 356 samples of human sera collected from native patients in two distinct zones of Somalia, 53% were positive (greater than or equal to 1:8) to the dye-test for Toxoplasma gondii antibodies. A significantly lower incidence (P less than 0.01) of infection was found in patients living in the arid Mogadishu area, compared to that in patients from villages on the river borders, situated in humid soil zones. Furthermore, in 4.2% of the river area cases the titres were over 300 I.U., indicating that acute T. gondii infection exists among the Somalian population. These differences were regarded as being due to climatic and geographical conditions rather than to diet or socio-economic conditions.

Antibodies↗
PubMed1980

The enzyme-linked immunosorbent assay (ELISA) in the diagnosis of toxoplasmosis.

In this note we described the E.L.I.S.A. test, applied to diagnostic of Toxoplasmosis, at short period of reaction. The reading has been made with naked eye. The examined sera have been previously titred to the Dye test. The authors have been able to establish the antigenic dilution as well as the short period of the best reaction to carry on the E.L.I.S.A.

Enzyme-Linked Immunosorbent Assay↗
PubMed1979

Histoplasmosis diffusion in Somalia: study of skin-test and serological survey.

Histoplasmin skin-test was applied to 1014 patients in two different parts of Somalia: in Mogadishu, an arid area, and in Jilib, a southern village on the banks of the Juba river. Among these patients only three gave areas of induration greater than 5 mm in diameter; all reactors were from Jilib. Results of a serological survey (latex-agglutination test) of histoplasmosis antibodies among 203 Somalian patients from three villages in river valleys are compared with the results of 171 inhabitants of the town of Mogadishu. Indirect agglutination antibody titers greater than or equal to 20 were found in 21.6% of the Mogadishu population as compared to 52.2% found in the river villages. In 96.2% of our cases in which the two tests were contemporarily used, the skin-test was completely negative despite high titres of positivity in the serological test. The results indicate the existence of founts of histoplasmosis infection in Somalia, particularly in humid areas bordering the rivers rather than in the surrounding arid semi-desert area characteristic of most of the country.

Female↗