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Biomedical subjects

E Agner

Publications and source records attributed to E Agner.

At least 55 records · Page 3Linked to original sources
PubMed1983

Fasting serum cholesterol and triglycerides in a ten-year prospective study in old age.

In a ten-year prospective study of a population of men and women aged exactly 70 at entry and otherwise selected only according to geography, the predictive values of serum cholesterol and serum triglycerides were evaluated concerning total mortality and cardiovascular disease (CVD) and cancer manifestations in the eighth decade. Both high and low cholesterol values at 70 were associated with excess total mortality in men, the former showing excess CVD mortality, the latter excess cancer mortality. In men, high values of triglycerides at 70 were associated with increased CVD mortality as well as CVD development. In women, high values of triglycerides at 70 were associated with excess hospitalization for cerebrovascular incidence alone.

Aged↗
PubMed1983

The significance of systolic hypertension in the 1897-population in Glostrup.

The predictive value of a high diastolic or systolic blood pressure for presence or development of cardiovascular disease diminishes with age. In the present 10-year prospective study of 70-year-olds a Cox regression analysis for competing risk markers for cardiovascular events in the eighth decade was carried out. This analysis showed that neither high diastolic nor high systolic blood pressure had individual predictive value for death from cardiovascular diseases. Concerning development of cardiovascular diseases, however, high systolic blood pressure had individual predictive value in both sexes.

Age Factors↗
PubMed1983

Predictive value of arterial blood pressure in old age. A ten-year prospective study of men and women born in 1897 and examined at the age of 70 and 80 years.

In a 10-year longitudinal study of men and women aged exactly 70 at entry and otherwise only selected according to geography, the predictive value of arterial blood pressure was evaluated concerning cardiovascular disease (CVD) at entry and CVD development or death during the following decade. At 70 the prevalence of arterial hypertension (greater than or equal to 160/95 mmHg) was 46% in men and 45% in women. At 80 these prevalences were 19 and 30%, respectively. In women, this fall could partly be explained by an association between high blood pressure and excess mortality. In both sexes it could partly be explained by an increasing part of the population being treated with antihypertensives/diuretics, partly by an association with myocardial degeneration. In a Cox's regression model for competing risks at 70, high systolic blood pressure had independent, predictive value for excess CVD mortality in the eighth decade in women alone, and for excess CVD development in both sexes. High diastolic blood pressure had no independent predictive value for any of these end points.

Aged↗
PubMed1982

Serum 1,25-dihydroxyvitamin D in normal subjects and in patients with postmenopausal osteopenia. Influence of age, renal function and oestrogen therapy.

The serum concentrations of 1,25-dihydroxyvitamin D (1,25-(OH)2D) were measured in 194 healthy subjects aged 15-90 years. The mean level was 32.8 +/- 12.5 pg/ml (SD) without age-dependent changes. The mean serum concentration was reduced (26.9 +/- 13.6 pg/ml) in 55 patients with postmenopausal osteopenia compared to 62 non-osteopenic age-matched controls (32.8 +/- 11.6 pg/ml) (p less than 0.02). The serum concentrations correlated positively with the creatinine clearances in 23 osteopenic patients studied. Treatment with oestradiol increased serum 1,25-(OH)2D significantly in postmenopausal women. A reduced production of 1,25-(OH)2D or a reduced sensitivity to this hormone may play a significant role in the pathogenesis of postmenopausal osteopenia.

Adolescent↗
PubMed1981

Blood pressure reduction by change in life style. The CVD intervention study in Glostrup.

In a controlled, primary intervention, cardiovascular survey on 928 men and women aged exactly 30, 40, 50 & 60 years, a significant reduction (about 5 mmHg) was found in systolic blood pressure mean difference before and after intervention between the intervention- and control group. The observation time was 7 months. Most of the twentynine drop outs were excluded for personal reasons or because of antihypertensive treatment. A reasonable explanation for the blood pressure reduction is a change in life style, in the intervention group. The subjects in the intervention group increased physical activity and decreased fat and salt intake in contrast to the control group (p less than 0.001, 0.005).

Adult↗
PubMed1981

Arterial hypertension in 70 - 80 year old men and women.

In a longitudinal study of an unselected population of men and women standardized arterial blood pressure was measured at 70 and again at 80. At 70 the prevalence of arterial hypertension (greater than or equal to 160/95 mmHg) was 46% in men and 45% in women. At 80 it was only 19% and 30%. This decrease was partly owed to an increased ten year mortality in hypertensive 70 year old women. However, also a significant individual decrease was seen in the participants examined twice, - a decrease that did not seem connected to the increased use of antihypertensive medicine and was not connected to the presence of arteriosclerotic symptoms, but showed a connection to pathological ECG-changes at 80.

Age Factors↗
PubMed1981

Cholesterol, high density lipoprotein-cholesterol (HDL) and cholesterol/HDL-ratio versus arterial blood pressure.

In a cardiovascular survey of 928 men and women aged exactly 30, 40, 50 & 60 years, a correlation between serum cholesterol, cholesterol/HDL-ratio and arterial blood pressure was found. This correlation was indirectly caused by mutual correlations to relative weight and age as a final result found after multiple rank correlation analysis in each sex. HDL was not correlated to arterial blood pressure at all.

Adult↗
PubMed1981

Natural history of angina pectoris, possible previous myocardial infarction and intermittent claudication during the eighth decade. A longitudinal epidemiologic study.

A ten-year longitudinal cardiovascular survey of an unselected population of 70- and 80-year-old men and women was carried out as part of the Glostrup Population Studies in Denmark. With small reservations, the population at entry was representative of the Danish people of that age group, and representative in terms of mortality during the following decade. The prevalences of three major cardiovascular symptoms are given together with their courses, incidences and relationship to some common cardiovascular risk factors. At 70, the prevalence of angina pectoris was 10% in men and 5% in women, the corresponding values for possible previous myocardial infarction being 5% and 3%, and for intermittent claudication 9% and 3%, with statistically significant differences between the sexes for any of the three symptoms. At 80, the prevalences of all three symptoms in women had risen to equal that of men, which had not changed. Total ten-year mortality was significantly increased among men who had confirmed angina pectoris or possible previous myocardial infarction at 70 and among women who had confirmed intermittent claudication. Ten-year mortality from all cardiovascular diseases, and also from acute myocardial infarction alone, showed exactly the same pattern. In those examined at both 70 and 80, the ten-year incidences of the three symptoms were 3-11%. Few participants who had confirmed a symptom at 70 denied it at 80.

Aged↗
PubMed1981

Prevalence of raised Yersinia enterocolitica antibody titre in unselected, adult populations in Denmark during 12 years.

Yersinia enterocolitica biotype 4, serotype 0:3 is by far the most common human pathogenic Yersinia enterocolitica subtype in Scandinavia. It is extraordinarily immunologically specific, and an elevated antibody titre greater than or equal 80-160 is known to indicate acute infection. This titre was measured in five population surveys conducted in 1967-78, including 3278 examined adult men and women. The prevalence of titre elevation greater than or equal to was 1.0% in 1967. In 1978 it was significantly higher, 7.7%, and also the individual course of the titre in a ten-year longitudinal survey showed a significant increase in this prevalence, indicating an increasing incidence of infection. Significant sex and age differences were seen, women and younger subjects being more frequently affected than men and older subjects. The prevalence of elevated titre showed a seasonal variation with a maximum in the spring and autumn.

Adolescent↗