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E Akamatsu

Publications and source records attributed to E Akamatsu.

8 recordsLinked to original sources
PubMed2001

[Cave-associated acute pulmonary histoplasmosis in two Japanese returning from Mexico].

We report cases of cave-associated acute pulmonary histoplasmosis that occurred in two Japanese returning from Yucatan, Mexico. Patient 1 is a 35-year-old woman who worked in a bat-infested cave in Mexico for about 3 weeks. Almost all her colleagues had developed cough, fever and headache after 5 days in the cave. She was asymptomatic but her chest radiograph showed multiple nodules 5-10 mm in diameter throughout both lungs. The histoplasmal mycelial-phase complement fixation titer on admission was 1:16, and 1:128 one month later. Patient 2, the 53-year-old husband of patient 1, was also infected by histoplasma in the cave, and similar nodules were observed in his chest radiograph. His histoplasmal complement fixation titer did not elevate. To date, about 20 cases of pulmonary histoplasmosis have been reported in Japan. The number of imported mycoses in Japan is increasing, and histoplasmosis should be considered in the differential diagnosis of pulmonary nodules in travelers returning from endemic areas.

Acute Disease↗
PubMed1998

Transcription factor E2F and cyclin E-Cdk2 complex cooperate to induce chromosomal DNA replication in Xenopus oocytes.

Although no chromosomal DNA replication actually occurs during Xenopus oocyte maturation, the capability develops during the late meiosis I (MI) phase in response to progesterone. This ability, however, is suppressed by Mos proteins and maturation/mitosis promoting factor during the second meiosis phase (meiosis II; MII) until fertilization. Inhibition of RNA synthesis by actinomycin D during early MI prevented induction of the replication ability, but did not interfere with initiation of the meiotic cell cycle progression characterized by oscillation of the maturation/mitosis promoting factor activity and germinal vesicle breakdown. Microinjection of recombinant proteins such as dominant-negative E2F or universal Cdk inhibitors, p21 and p27, but not wild type human E2F-1 or Cdk4-specific inhibitor, p19, into maturing oocytes during MI abolished induction of the DNA replication ability. Co-injection of human E2F-1 and cyclin E proteins into immature oocytes allowed them to initiate DNA replication even in the absence of progesterone treatment. Injection of cyclin E alone, which was sufficient to activate endogenous Cdk2 kinase, failed to induce DNA replication. Moreover, the activation of Cdk2 was not affected under the conditions where DNA replication was blocked by actinomycin D. Thus, like somatic cells, both activities of E2F and cyclin E-Cdk2 complex are required for induction of the DNA replication ability in maturing Xenopus oocytes, and enhancement of both activities enables oocytes to override DNA-replication inhibitory mechanisms that specifically lie in maturing oocytes.

Animals↗
PubMed1989

[Trends in the use of antimicrobial agents in Kanagawa Dental College, Hospital].

The development and expansion of antimicrobial agents has made a remarkable improvement. Recently we began to use newqinolon agents, furthermore we began to use the third generation of oral cephem agents. We anticipate we will have a large change of trends in the use of antimicrobial agents. We investigated the trends in the use of antimicrobial agents between April 1st, 1983 to March 31st, 1988, to prepare for the trends in the future. 1) A total use of antimicrobial agents in Kanagawa Dental College, Hospital has increased 19% over the last five year. 2) Trends in the use of injection of antimicrobial agents has decreased over the same period of time, otherwise trends in the use of oral antimicrobial agents has increased tremendously 3) The use of newqinolon agents were less than 0.07% in one year.

4-Quinolones↗
PubMed1987

[A report of a resected case of malignant lymphoma combined with follicular carcinoma of the thyroid].

A 66-year-old female administered with complaining of cervical mass. All of the thyroid function tested were within normal limits. A diagnosis of Malignant lymphoma was done by fine aspiration cytology. Total thyroidectomy and dissection of bilateral regional lymph nodes were performed. And additional chemotherapy is continued. The histological findings revealed diffuse lymphoma, mixed type (LSG), but there is no invasion of the lymphoma cell to the lymph node. There are also two follicular carcinomas with metastasis to the dissected regional lymph nodes. In the residual thyroid tissue, the findings of chronic thyroiditis was shown histopathologically.

Adenocarcinoma↗
PubMed1975

Gamma camera images of the salivary gland using 99mTc. Report of four cases.

Following the intravenous injection of 99mTc pertechnetate, the gamma camera enabled us to define the dynamic characteristics of salivary gland function as well as morphologic characteristics in a normal patient and in three patients with diseased parotid glands. We will continue this study in an attempt to define further the functional and morphologic characteristics of abnormal salivary glands.

Adenocarcinoma↗