Biomedical subjects

E Alture-Werber

Publications and source records attributed to E Alture-Werber.

10 recordsLinked to original sources

PubMed1985

An animal model of Curvularia geniculata and its relationship with human disease.

The conidiospore of Curvularia geniculata was observed in the bronchial washings of a patient who subsequently developed pulmonary aspergillosis. Curvularia geniculata was grown in culture and used in experiments in mice to explore its possible role as a disease causing agent. The fungus, after intraperitoneal injection, produced granulomas in the liver and spleen. Studies on the pathogenicity of this fungus in mice produced similar lesions to those observed in the human case. A comparison of the lesions in the patient's lung and in the animal experimental model is presented.

Adult↗

PubMed1980

Esculin-based medium for isolation and identification of Cryptococcus neoformans.

A simple medium was developed, using esculin as the substrate, for the isolation and identification of Cryptococcus neoformans. C. neoformans produced a brown-black pigment on the medium; all other yeasts produced no pigment or were light yellow. Esculin is beta-glucose-6,7-dihydroxycoumarin. C. neoformans produced pigment because the 6,7-dihydroxycoumarin component of the esculin molecule was converted to a melanin-like pigment. We think the reaction was similar to the conversion of diphenols, aminophenols, and diaminobenzenes to melanin. Laboratory studies with isolates of C. neoformans, C. albidus, C. luteolus, and C. terreus and representatives of the genera Candida, Torulopsis, Geotrichum, and Rhodotorula, plus environmental field studies, demonstrated that over 95% of C. neoformans isolates were correctly identified, whereas all other fungi were excluded. Esculin agar was a sensitive, specific medium for the isolation and identification of C. neoformans. It was inexpensive and had a long storage life.

Cryptococcus↗

PubMed1976

Pulmonary infection with Allescheria boydii.

Allescheria boydii, the most common fungus isolated from North American maduromycosis, is a well-described pathogen. Reports of its isolation from sites other than the extremities are rare. Only ten cases of pulmonary infection are recorded in the literature. Of these, two are primary infections, and eight are secondary. An eleventh case is reported. Although there are some elements in the patient's history that indicate that this infection is secondary, the authors regard the infection a primary one. A pathologic and microbiologic compendium of all 11 cases is presented.

Aged↗

PubMed1976

Immunization of mice with a mutant of Cryptococcus neoformans. Characterization of the mutant, actively acquired resistance to experimental cryptococcosis in mice.

In 69% of subdermally and 50% of subcutaneously immunized mice, immunity against Cryptococcus neoformans was obtained. The vaccine consisted of a gamma-irradiated mutant, which grew well at 5 degree C and at room temperature. Many subcultures and animal passages did not restore this mutant to the encapsulated, pathogenic wild type.

Animals↗

PubMed1973