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Biomedical subjects

E Amado

Publications and source records attributed to E Amado.

3 recordsLinked to original sources
PubMed1997

[Analysis of prescriptions in primary care: evaluation of a system of indicators].

OBJECTIVE: To evaluate a system of qualitative indicators which serve as a tool for prioritising the level of intervention in Base Health Districts (BHDs). DESIGN: Retrospective, descriptive study. SETTING: Primary Care. MEASUREMENTS AND MAIN RESULTS: Medical prescription dispensed by the doctors from 36 BHDs in the Costa de Ponent (Barcelona) region in 1995 were analysed, with different qualitative indicators used. Three stages of indicators were established. 25% of the BHDs had a %PIV < 75%; 25% of them over 80%; and the rest between 75 and 80%. CONCLUSIONS: The three stages of indicators described contribute different and complementary information to the qualitative prioritising of pharmaceutical prescription. Absence of correlation between the third-stage indicators suggests the importance of choosing them according to the desired pharmacological group and in line with a pre-established criterion for selecting medicines.

Drug Prescriptions↗
PubMed1986

Pharmacokinetics of the combination of ticarcillin with clavulanic acid in renal insufficiency.

The pharmacokinetics of ticarcillin and clavulanic acid were studied by blood and urine assay methods in 25 patients divided into five groups with varying degrees of renal insufficiency i.e. mild, moderate and severe renal insufficiency, almost anuric patients and those requiring haemodialysis (groups A to E). A single dose of 5.2 g Timentin (5.0 g ticarcillin and 200 mg clavulanic acid) was administered intravenously by infusion over 30 min. The average elimination half-life (T1/2) of ticarcillin increased from 0.95 h in patients with creatinine clearance (Clcr) of 80 ml/min to 1.8, 4.4, 6.9 and 11.2 h respectively in mild, moderate and severe renal insufficiency and in almost anuric patients. The T1/2 values for clavulanic acid were 0.75, 0.9, 2.0, 2.5 and 4.8 h in the same groups. The area under concentration-time curve (AUC) for ticarcillin increased from 787 to 2839 mg/l/h and for clavulanic acid from 12.8 to 29 mg/l/h when group mean values from patients with mild and severe renal insufficiency were compared. The plasma clearance (Clpl) of clavulanic acid was in all groups greater than that of ticarcillin i.e. 166 and 100 ml/min vs. 79.2 and 25.0 ml/min when comparing mean values from groups with mild and severe renal insufficiency respectively. The plasma clearance ratio clavulanic acid/ticarcillin increased proportionally to the degree of renal insufficiency from a value of 1.5 in normal subjects to between 3.3 and 3.8 in more advanced cases.(ABSTRACT TRUNCATED AT 250 WORDS)

Acute Kidney Injury↗