PubMed Health⌕ Search

Biomedical subjects

E Andersen

Publications and source records attributed to E Andersen.

At least 127 records · Page 7Linked to original sources
PubMed1984

Thyroid stimulating immunoglobulins in Graves' disease with goitre growth, low thyroxine and increasing triiodothyronine during PTU treatment.

In 50 consecutive patients with Graves' disease treated with PTU, 7 (group 1) developed increasing goitre in spite of unmeasurable TSH. Thyroid variables were compared with those from 10 controls with an ordinary response to PTU (group 2). Serum T4 decreased in group 1 from 246 +/- 47 nmol/l (mean +/- SD) to 40 +/- 9 nmol/l after 6 weeks of PTU treatment and continued to be below the normal range during the next 4 months. In group 2 serum T4 decreased from 190 +/- 35 to 88 +/- 47 nmol/l and stayed in the normal range. Serum T3 was normalized in both groups after 6 weeks but increased to values above the normal range in group 1 after that time. In spite of unmeasurable TSH during the 6 months of treatment in group 1, thyroid volume, determined ultrasonically, increased significantly from 60 +/- 29 to 93 +/- 68 ml (P less than 0.05), but was unaltered in group 2 about 25 ml. Thyroid stimulating antibodies (TSAb) measured by adenylate cyclase activation (normal below 109%) decreased in group 2 from 117 +/- 23 to 90 +/- 17% (P less than 0.01) (6 months of therapy), but increased significantly in group 1, from 201 +/- 47% to a maximum value of 234 +/- 69% (P less than 0.05). TSH binding inhibitory immunoglobulins (TBII) (given as per cent inhibition, normal below 26%) decreased in group 2 from 43 +/- 29 to 29 +/- 27% (P less than 0.05) but were unaltered high in group 1, 66 +/- 25% before therapy and 57 +/- 26% after 6 months of therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1984

Preservation of structural specificity in free gingival grafts. Long-term histological observations in man.

Most of the previous histological studies devoted to free gingival grafts in humans were limited to the description of the various phases of healing between the graft and the subjacent tissues. The present long-term study illustrates the histological findings 1 to 36 months after grafting along the zone of passage between graft and surrounding tissues. In the transitional zone between graft and alveolar mucosa it was found that the structural characteristics of the palatal mucosa, with its dense network of collagen fibres and its orthokeratinized superficial layer were conserved even after an interval of time as long as 16 months. These features contrasted with the loose network of collagen fibres and the presence of numerous elastic fibres in the alveolar mucosa. As for the transitional zone between graft and gingiva the findings confirmed that these two types of mucosa are similar, except that the gingival epithelium showed, in epon embedded sections, a layer of parakeratinization, as opposed to the dense layer of orthokeratin found on the grafted palatal epithelium. A constant feature in the present investigation was the change in orientation of the collagen fibres along the zones of healing, both between graft and alveolar mucosa and between graft and gingiva.

Alveolar Process↗
PubMed1983

An ascending serotonergic pain modulation pathway from the dorsal raphe nucleus to the parafascicularis nucleus of the thalamus.

Three types of spontaneously active neurons were found in the parafascicularis (PF) nucleus of the thalamus of the rat: slow firing units (0.5-10 spikes/s), bursting units (2-5 spikes/burst in 10-20 ms, one burst every 1-2 s) and fast firing units (15-40 spikes/s). A similar population of neurons was found in the PF of rats treated with 5,7-dihydroxytryptamine (5,7-DHT), a serotonin neurotoxin. Noxious tail pinch (TP) caused 68% of the PF neurons to increase their firing rates to 242% of their initial baseline activity, while non-noxious touch stimulation failed to induce a response. In the 5,7-DHT-treated rats, TP caused 85% of the neurons in the PF to increase their firing rates to 581% of their initial baseline activity and 22% of the neurons increased their firing in response to touching the tail. Both the number of cells responding (P less than 0.05) and the percentage increase (P less than 0.001) were statistically greater in serotonin-depleted rats than in controls. This indicates that serotonin (5-HT) has a tonic inhibitory influence on responses to both noxious and non-noxious sensory stimuli. In control rats, electrical stimulation of the dorsal raphe nucleus (DR) decreased the firing rates of PF neurons. In contrast, the same DR stimulation induced an increase in PF firing rates during stimulation in serotonin-depleted rats and this increase in firing rates remained several seconds after cessation of stimulation. This indicates that the DR may use at least two different neurotransmitters in its projections to forebrain structures. In control rats, the TP stimulation induced an increase in firing rates of rates of PF neurons while DR stimulation attenuated the excitation induced by TP stimulation. In serotonin-depleted rats, DR stimulation and TP both caused an increase in firing rates. This effect was not additive indicating that there may be a serotonergic projection from the DR to the PF which modifies responses to somatosensory stimuli. The inhibitory effects elicited by electrical stimulation were limited to the immediate area of the DR. Stimulation of the adjacent reticular formation 1 mm lateral to the DR produced the opposite effect, an increase in firing rate often accompanied by driven spike activity in the PF.

Animals↗
PubMed1983

Dorsal raphe stimulation reduces responses of parafascicular neurons to noxious stimulation.

Spontaneous activity, responses to noxious stimulation and response to electrical stimulation of the dorsal raphe were recorded extracellularly from single units in the parafascicularis (PF) nucleus in the rat. Three types of spontaneous activity were found: 'slow' firing units (1-10 spikes/sec), 'bursting' units (bursts of 2-5 spikes/10-20 msec, bursts repeat every 1-2 sec), and 'fast' firing units (15-40 spikes/sec). Noxious stimulation increased the firing rate of 63% of the slow cells and 87% of the bursting cells, while the fast firing units did not respond. Dorsal raphe (DR) stimulation decreased the firing rates of both the slow and bursting PF cells only. The degree of suppression of PF units was directly related to the frequency and intensity of the DR stimulation. When the noxious stimulus was combined with DR stimulation, DR stimulation inhibited the increase in firing rate caused by the noxious stimulus. The firing rate during combined DR stimulation and noxious stimulation averaged 51% of that during the noxious stimulation alone. In several units, DR stimulation had no effect on spontaneous activity when applied alone but did decrease the effects of noxious stimulation when applied simultaneously. The results indicate that in addition to other possible mechanisms, the DR may affect responses to noxious stimuli via an ascending modulation pathway to the parafascicularis nucleus in the thalamus.

Animals↗
PubMed1983

Plasmapheresis in the treatment of psoriasis. A controlled clinical study.

Six patients with long-standing, moderately active plaque/nummular psoriasis were treated with either plasmapheresis or sham-plasmapheresis once weekly for 7 weeks in a double-blind controlled trial. No difference was found between active treatment and placebo. The marginal effect, which might be demonstrated by a larger study, is too small to justify this expensive modality of treatment.

Adult↗
PubMed1983

Extrahypothalamic brain luteinizing hormone: characterization by radioimmunoassay, chromatography, radioligand assay and bioassay.

We have recently reported that luteinizing hormone (LH) is present in the hypothalamus of rats. It has chromatographic and biologic characteristics similar to pituitary LH. In this report we focus on extrahypothalamic LH that is widely distributed in the rodent central nervous system. This material has a chromatographic profile similar to that of pituitary LH. Serial dilution of this material is parallel with dilutions of rat pituitary LH in the immunoassay. Brain extracts are active in the testis LH radioligand receptor assay and in the rat interstitial cell testosterone secretion bioassay. Prior incubation of extract with LH antibody significantly attenuated both of these activities. Thus, extrahypothalamic LH has immunologic, chromatographic, and biologic characteristics similar to hypothalamic and pituitary LH.

Animals↗
PubMed1983

Electrophysiological evidence of concurrent dorsal raphe input to caudate, septum, habenula, thalamus hippocampus, cerebellum and olfactory bulb.

Field potentials evoked by electrical stimulation of the dorsal raphe nucleus (DR) were recorded in eight forebrain structures in the rat. The areas were chosen chiefly for their anatomical connections to the DR and included the olfactory bulb (OB), caudate nucleus (CN), lateral septum (Spt), lateral habenula (Hb), parafascicularis (PF), ventral thalamus (VT), hippocampus-CA1 (Hipp), and cerebellum (CB). DR stimulation evoked an initial biphasic positive-negative wave form at similar latencies in each of the eight structures. A later positive-negative-positive wave was evoked in only six structures: CN, Spt, Hb, PF, VT, and Hipp. The amplitudes and latencies of the peaks of the later wave forms varied among structures. A depth profile recording procedure created by moving the DR stimulating electrode showed that the responses in the remote structures occurred only when the stimulating electrode was located in the DR. Bursting the DR at 20 Hz for 5-20 min caused a decrease in all components of the response. The evoked potential amplitude returned to baseline levels 5-30 min after cessation of stimulation. The results indicates that the dorsal raphe has a concurrent input to many areas of the brain receiving 5HT afferents and that DR stimulation can modulate the neuronal activity in these regions.

Animals↗
PubMed1982

Partial Turner's syndrome in four girls with Xq duplication and Xp deficiency.

Four girls with some clinical symptoms of Turner's syndrome had Xq duplication and Xp deficiency, their karyotypes being 46,X,dup(X)(p113;q11), 46,X,dup(X)(p212;q211), 46,X,dup(X)(p225;q13), and 46,X,dup(X)(p222;q213). No mosaicism was found. The major clinical findings, short stature, lack of pterygium colli, and no continuous gamete production, are compared with those in three previously published cases.

Adolescent↗
PubMed1982

Monocytotoxic antibodies after bone marrow transplantation in aplastic anemia.

Pre- and post transplant sera from 51 cases of bone marrow transplants performed for severe aplastic anemia were tested on monocytes (M) and corresponding B cells (B) from a panel of unrelated donors. One-third of the sera were cytotoxic for B and M either from different or from the same individuals, while 45% reacted only to M and appeared to recognize non-HLA M-associated antigens. No significant reaction to endothelial cells was obtained from these sera. The subsequent clinical course was not associated with any reaction pattern of pre-transplant sera. There was a significant relationship between rejection and the development of M antibodies after grafting, but since these were also found in many other patients without rejection, their occurrence has no predictive value for an individual patient.

Anemia, Aplastic↗
PubMed1982

Dorsal raphe nucleus modulates sensory evoked responses in caudate and septum.

The dorsal raphe nucleus (DR) was examined for its possible modulatory effects on sensory input to the caudate nucleus (CN) and lateral septum (Spt) in freely behaving rats. Three types of DR stimulation were tested for their effects on sensory evoked responses: (1) a single pulse of electrical stimulation of the DR prior to each sensory stimulus, (2) a 5-20 min burst of 20 Hz stimulation of the DR prior to sensory stimulation, and (3) a combination of the single pulse and the 5-20 min burst (20 Hz) stimulation of the DR prior to the sensory stimulation. Each of the three forms of DR stimulation caused a decrease in the amplitudes of the sensory-evoked responses recorded from the CN and Spt. Combination of DR stimulation caused stronger (summation) attenuation of the sensory responses. Thus, DR was shown to affect sensory input recorded in CN and Spt.

Animals↗