[Initial leukemic phase of ALK+ anaplastic large T-cell lymphoma, small cell variant].
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Adult↗
Biomedical subjects
E André-Kerneïs
Publications and source records attributed to E André-Kerneïs.
[Binucleated lymphocyte lymphocytosis].
We reported here a case of persistent polyclonal B-cell lymphocytosis (PPBL) in a 31-year-old female patient. Peripheral blood smears showed atypical binucleated lymphocytes which were polyclonal B-cells with kappa and lambda expression, and without clonal rearrangement of immunoglobulin heavy chain. Cytogenetic analysis found a trisomy 8, with premature chromosome condensation. Clinically, PPBL is associated with moderated splenomegaly, adenopathy, and smoking. It remains to be established whether PPBL is a real pathology or a simple cytological abnormality.
Adult↗
[Role of platelet dysfunction in the haemostatic manifestations occurring during essential thrombocythaemia].
Among myeloproliferative disorders, Essential Thrombocythaemia is the most frequent and the one associated with the better prognosis. Although median survival is above 15 years, Essential Thrombocythaemia may be complicated by haemostatic life-threatening manifestations. Occurrence of thromboembolic or haemorrhagic episodes, even both in a same patient, are not predictable and physiopathology of Essential Thrombocythaemia remains misunderstood. Many studies have been conducted to explain the mechanisms responsible for the haemostatic complications and to determine predictive biological factors in order to improve the management of patients. We report here a review of the potential roles of platelets in Essential Thrombocythaemia through their interaction with coagulation and fibrinolysis systems as well as with cellular components (leukocytes and endothelium). Many controversial data have been published so far. However, a deficiency in high molecular multimers of von Willebrand factor is currently admitted, as well as deficiency of platelet membrane proteins and the presence of circulating activated platelets, especially in erythromelalgia. However, no biological abnormality has been correlated with the clinical manifestations. The haemostatic complications are likely to result from a multifactorial process in which accumulated moderated risk factors unbalance the procoagulant/anticoagulant pathways.
Blood Platelets↗