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Biomedical subjects

E Angelucci

Publications and source records attributed to E Angelucci.

125 records · Page 7Linked to original sources
PubMed1985

[Changes in body composition in obese patients on a low-calorie diet].

Energy balance was studied on 4 obese hospitalized subjects kept on hypocaloric diet (489 Kcal - 54% CHO, 10,6% Fat, 35,4% Protein) for 18 +/- 3,7 days. Energy expenditure was measured trough heart-rate monitoring (individual calibrations before and after the study were performed) and nitrogen balance was computed to establish protein loss. Individual qualitative composition of body weight loss was then assessed: 71,4 +/- 5,23% could be attributable to fat loss, 9,38 +/- 3,32% to protein loss, 18,2 +/- 5,5% to water loss. Part of this last figure could be attributable to a slight under-estimation of the method utilized to measure the energy expenditure (heart-rate monitoring).

Adult↗
PubMed1984

[Circadian and circumannual variations in the level of plasma TSH and prolactin in healthy adult males].

4 healthy young volunteers were submitted to the study of circadian and circannual oscillations of plasma TSH and Prolactin. Our data demonstrated the existence of a circadian rhythm for TSH with acrophase at 04,39 and a circannual rhythm of the same hormone with acrophase in January. While for Prolactin it was possible to detect a circadian rhythm with acrophase at 04,29. We failed to demonstrate any circannual variation of plasma hormonal levels.

Adult↗
PubMed1984

[Modifications in the oscillation of substrates in obese subjects subjected to variations in the pattern of meal-timing].

In a group of obese subjects kept on hypocaloric diet during a period of 18 days, an eventual different behaviour of carbohydrates and lipids oxidation following to meal-timing manipulation (a single meal given only at 10.00 hr or at 18.00 hr of each day) has been studied by indirect calorimetry. No significant difference of body weight reduction was noticed in both dietetic regimens. In the group of obese subjects who consumed the single meal at 10.00, a slight increase of carbohydrates oxidation was noticed, without a statistical significance, whereas in the group with single meal at 18.00 h a significant increase of lipids oxidation resulted.

Adolescent↗
PubMed1984

[Basal blood glucose oscillations in diabetics treated with microinfused insulin. Comparison between hormonal distributions by the square wave-form at various frequencies].

Basal glycemic oscillations in 3 type I-diabetics treated with continuous subcutaneous insulin infusion (CSII) and without endogenous insulin secretion have been studied. Insulin infusion with different frequencies of square wave-form basal insulin delivery (1 min and 10 min) have been utilized. Aim of the present investigation was to observe whether basal blood glucose oscillations could be affected by the frequency of basal square wave-form insulin delivery. Blood glucose has been measured at 3 min intervals for 90 min for each frequency. The glycemic patterns obtained did not show any periodism in relationship with the two frequencies engaged, hence the glycemic fluctuation, similar between the two experiments, cannot be considered as dependent on the different frequency of insulin pulses.

Blood Glucose↗
PubMed1983

[Time structure of endocrine secretion. II. Circannual variations in the free fractions of tri- and tetraiodothyronine, cortisol, human growth hormone and plasma insulin in healthy subjects].

Circadian and circannual variations of several endocrine activities and their biological implications in health and diseases were described in men. Aim of our work was to perform a further observation on circannual bioperiodicities of some hormone: free fractions of T3 and T4, cortisol, HGH, PTH and serum insulin. Four healthy young males volunteered to be submitted to the study from June and their blood-samples collected six times a day, every other month, in the course of one year. Our data were analysed by macroscopic (mean chronogram) and microscopic (Cosinor test) methods. First we could document a circadian phase-shift of the highest peak of secretion, occurring in the course of the year, for FT3, FT4, Cortisol, HGH and serum basal insulin. Then we could detect a circannual oscillation of the highest diurnal secretion for FT3 (October), cortisol (December) HGH (April) and serum basal insulin (February). FT4 showed the lowest secretion in October. Almost the same cyclic variations were demonstrated when Mesors and Amplitudes of the same values were examined except for slight shiftings. PTH showed no cyclic variation during the period of observation.

Adult↗
PubMed1983

[1) Temporal structure of endocrine secretion: circannual changes in insulin responsiveness to tolbutamide in man].

In our previous observations we could detect the existence of circadian rhythms of either tolbutamide-induced insulin release with the acrophase early in the morning (at 04.20) or an insulin-induced hypoglycemia with the acrophase at 10.30 a.m. Aim of our work was to extend the observation to circannual rhythms of the same parameters. Four healthy young volunteers were submitted to the study in the early months of the year and observed in a 24 hrs-period, every other month, in the course of one year. 250 mg tolbutamide were injected i.v. in each day of the experiment every four hours with starting points at a random sequence. The data were analyzed by microscopic analysis: Halberg's Cosinor method. The highest insulin release occurred in winter (Acrophase: Jan. 19 with 95% confidence limits: Oct. 31 - April 1).

Adult↗
PubMed1983

[Biphasic response of insulin secretion to arginine stimulation: daily changes].

8 healthy subjects were infused with arginine at h. 08 and h. 16 of different days in order to observe if some changes occurred in the biphasic insulin response according with the different times of the day. A statistical difference between the two responses could be observed only for the first phase of the insulin response (time 0' - 10'), that appeared greater in the morning. When the insulin areas were plotted against the percentage of Ideal Body Weight an highly statistically significant correlation was found.

Adult↗
PubMedDate not supplied

Bone marrow transplantation for thalassemia.

Early trials of allogeneic bone marrow transplantation (BMT) for homozygous beta-thalassemia and the analyses of results of transplantation in patients less than 16 years old have allowed us to identify three classes of risk using the criteria of degree of hepatomegaly, the degree of portal fibrosis and the quality of the chelation treatment given before the transplant. Patients for whom all three criteria were adverse constituted class 3, patients with none of the adverse criteria constituted class one and patients with one or various association of the adverse criteria formed Class 2. Most patients older than 16 years have disease characteristics that place them in class 3 with very few in class 2. For all the patients with an HLA identical donor we are actually using two Protocols for BMT to whom the patients are assigned on the base of the class they belong to at the time of BMT and independently on the age of the patient. For class 1, class 2 and for class 3 the probabilities of survival and of event-free-survival are respectively of 98% and 94%, 87% and 84%, 100% and 67%. For those patients that were older than 16 years at the time of the transplant, the probabilities of survival are 82% and the probabilities of event-free survival are 79%. Bone marrow transplantation is a new form of radical treatment of thalassemia in those patients with an HLA identical donor.

Adolescent↗
PubMedDate not supplied

Bone marrow transplantation in an HIV positive thalassemic child following therapy with azidothymidine.

The authors report their experience on allogeneic bone marrow transplant in an HIV seropositive thalassemic child. Before transplant a treatment with Azidothymidine was performed with the aim of reducing the viral load. Engraftment took place but, later, an explosive upsurge of viral disease occurred with encephalitis, positivation of the P24 antigen, proliferation of opportunistic infections and an increase of the IgG level. Furthermore the failure of CD4+ cell recovery was also observed. This case underlines that bone marrow transplantation can have a successful engraftment in HIV seropositive patients, but this doesn't modify the course of the infection.

Adolescent↗
PubMedDate not supplied

Angiotropic large-cell lymphoma with predominant kidney involvement. A case report.

The authors report a case of non Hodgkin lymphoma which, given its particular course and histomorphological features, can be classified as angiotropic large-cell lymphoma (i.e. proliferating angioendotheliomatosis). The most important characteristic is that the kidney was the target organ in this case, an observation rarely reported in the literature.

Female↗
PubMedDate not supplied

Allogeneic bone marrow transplantation for hematological malignancies following therapy with high doses of busulphan and cyclophosphamide.

Thirty patients with malignant hematological disease underwent allogeneic bone marrow transplantation following Busulphan (Bu) and Cyclophosphamide (Cy). The diseases were chronic myelogenous leukemia, acute lymphoblastic and non lymphoblastic leukemia, myelofibrosis and multiple myeloma in complete remission and in relapse. A sustained disease-free survival (DFS) was achieved in 0/5 acute leukemia patients transplanted in relapse, in 5/7 acute leukemia patients transplanted in remission (600-1550 days) and in 6/9 CML patients transplanted in the chronic phase of the disease (500-950 days). A sustained DFS was also achieved in one 2nd BMT for relapsed CML. The data suggest that the Bu-Cy protocol combines high tumor ablative capability with toxicity comparable to previously described conditioning regimens for allogeneic BMT, particularly in diseases involving a great expansion of the bone marrow.

Adolescent↗
PubMedDate not supplied

Antibodies to hepatitis C virus in thalassemia.

The presence of anti-HCV antibodies has been examined in a group of 256 consecutive thalassemic patients who received blood transfusions in several countries around the world. Overall 60% were found to be anti-HCV positive. A higher incidence of anti-HCV antibodies was noted in Italian patients with respect to patients living in Eastern countries, and in southern Italy with respect to northern Italy. Because these patients received a large portion of their transfusions before the anti-HCV test became available, these data indicate a higher anti-HCV seroprevalence among Italian blood donors and confirm published data indicating a higher seroprevalence in southern Italy. The anti-seropositivity correlated highly with serum transaminase elevation and with histological diagnoses of chronic active hepatitis.

Adolescent↗
PubMedDate not supplied

Intravenous chelation therapy during transplantation for thalassemia.

BACKGROUND: Thalassemia patients with heavy iron overload risk further increase of body iron stores after bone marrow transplantation (BMT) due to intensive red-cell transfusions in the post BMT course and to massive mobilization of iron deposits from marrow cells following the conditioning regimen. Nevertheless, iron chelation has not yet been used during the transplant period, mainly for concerns related to the toxicity and antiproliferative properties of the drug. METHODS: Fifteen thalassemic patients received desferrioxamine (DFO) before and during BMT according to two different schedules (first: from day -9 to day +60, and second: from day -9 to day -2, then from day +28 to day +60) at a dose of 40 mg/kg/day as a 24-hour intravenous infusion. RESULTS: The median time to neutrophil, platelet and erythrocyte recovery showed no difference between DFO-treated patients and the control group (18 days vs. 15, 16 vs. 18 and 22 vs. 23, respectively; p: N.S.). The incidence of acute GVHD was 23% in the DFO group and 13% in controls (p: N.S.). The median serum ferritin (SF) at 6 months after BMT was significantly lower in the DFO-treated patients (2081 versus 4187; p: 0.007) than in the control group. This difference continued to be evident, though not statistically significant, during longer follow-up. CONCLUSIONS: Intravenous DFO therapy during BMT does not seem to have affected the engraftment parameters or the incidence of infections or GVHD. No adverse effects were observed during the therapy. Therefore thalassemic patients with heavy iron overload can be candidates for a course of i.v. chelation during the transplant period. This therapy could also be followed by post-BMT iron removal (i.e. phlebotomies or desferrioxamine) to accelerate the clearance of body iron deposits.

Adolescent↗