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Biomedical subjects

E Armelin

Publications and source records attributed to E Armelin.

At least 37 records · Page 2Linked to original sources
PubMed1985

Laser surgery in enclosed spaces: a review.

We describe the results of experiments carried out in the arteries of dogs, rabbits, guinea pigs, and humans, normal or atheromatous, calcified, or not, with the application of the argon and CO2 laser, in vitro or in vivo, directly or indirectly. Similarly, we present the results of laser effects when radiation is delivered through a special catheter with the purpose of producing aortic insufficiency, opening pulmonary valvular stenosis, desobstructing carotid and coronary obstruction induced in dogs as well as atheromatous obstructions in human amputated legs. Arterial wall perforation was present in 50% of all cases. We suggest four options in order to diminish this adverse result: (1) the use of coherent optical bundles which will allow the proper guiding of the laser beam, (2) the construction of a special catheter for proper handling of the laser-carrying fiber, (3) a combination of optical and computer programs which will aid to identify calcified regions, and (4) the use of dyes which will be strongly and selectively absorbed by the atheromas and which will thus allow their destruction at low laser powers.

Animals↗
PubMed1983

Vascular anastomosis by argon laser beam.

Twenty-four mongrel dogs, weighing 13 to 24 kg, were used to study the effectiveness of anastomosis by Argon Laser beam. After anesthesia, intubation and controlled ventilation, they were submitted to three types of vascular anastomoses: saphenous vein intercarotid artery bypass; left mammary artery/left anterior descending coronary artery bypass; and veno-venous anastomosis. In all groups, 0.8 to 1.5 watts of Argon Laser power were applied for a total time of 90 to 300 seconds. The lower power was for veno-venous anastomoses and the greater was applied for arterial anastomoses. The mean values of resistance of the laser anastomosis to pressure-induced repture were 730 mm Hg in the immediate postoperative study, but increased to 2,500 mm Hg 30 days after surgery. No signs of occlusion were demonstrated at the anastomotic sites by the angiographic and anatomopathological studies performed.

Journal Article↗
PubMed1983

Morphological alterations in dura mater encephali used as ventricular wall grafts in the canine heart.

Structural changes within homologous dura mater patch-grafts surgically implanted in the right ventricular wall of the heart were studied in nine adult dogs utilizing light microscopy and transmission and scanning electron microscopy. Physical examination of the dogs after surgery presented no clinical signs of abnormalities caused by either the surgery or the nature of the graft. After one week of implantation, a fibrous organization extending from the wound margins over the entire graft greatly increased its thickness. In addition, it was observed that (1) an increase in cellularity, vascularity and connective tissue elements occurred on the external surface of the patch-graft, (2) these same changes occurred regardless of which surface (periosteal or arachnoidal) was used as the external or pericardial surface, (3) the graft core underwent a transition from a relatively acellular and avascular connective tissue structure into one that was heavily infiltrated by a variety of cellular elements and new blood vessels, and (4) these morphological changes were interpreted as an attempt to incorporate the graft into the host tissue, resulting in an increase in both viability and stability of the graft. These findings indicate that homologous dura mater is a suitable material for use in the surgical repair of the cardiac wall.

Animals↗
PubMed1983

Study of the periosteal and arachnoidal aspects of dura mater implanted surgically in the ventricular wall of the canine heart.

After surgical removal of a portion of the cardiac wall, homologous dura mater cardiac grafts were sutured to the margins of the incision in the sternocostal wall of the right ventricle of the canine heart and recovered after 1, 4, 6 and 8 weeks of implantation. Representative tissue specimens were processed for and studied by means of SEM and TEM. The primary objectives were to study morphological changes in the dura mater grafts used to repair the lesions or defects in the cardiac wall and to compare alterations in the periosteal and arachnoidal aspects of the dura mater grafts after being implanted for varying periods of time. After one week of implantation, an amorphous layer of fibrin was deposited on or near the luminal surface of the original dura mater grafts. At four weeks of grafts implantation, a 'remodeling' process was apparent below the luminal surface of the graft. Although a large accumulation of fibrin was still present at this time, there was also an increase in the number of cellular and fibrillar components within the implant. Large numbers of macrophages and active fibroblasts were visible at this time along with new collagen. At the sixth week of implantation, an abundance of active fibroblasts, the presence of normal collagen and a darkly staining material interpreted as recently synthesized connective tissue components, fibrin deposits and/or degenerating collagen were also observed. Phagocytosis of the remaining fibrin was noted during this period indicating a continuation of the remodeling process at the luminal surface. Finally, after eight weeks of implantation, it was revealed that the original densely woven and relatively acellular graft had become infiltrated with various blood cells and vascular channels.

Animals↗