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Biomedical subjects

E B Helm

Publications and source records attributed to E B Helm.

At least 55 records · Page 3Linked to original sources
PubMed1989

Change of causative organisms under antifungal treatment in immunosuppressed patients with HIV-infections.

Oral and esophageal candidosis are very common in HIV-infected patients. Due to the lack of efficacy of topical antimycotics in advanced stages of HIV-infection oral azoles are mainly used for treatment. Azoles most often used are ketoconazole and fluconazole. While Candida albicans clearly is the most frequently encountered yeast before and after treatment other species can be found somewhat less frequently after treatment. This especially applies to Candida glabrata. Candida spp. other than C. albicans obviously may cause manifest oral candidosis. This shift of microbes deserves the more interest as they are less susceptible to azole drugs.

Antifungal Agents↗
PubMed1989

[Ambulatory and inpatient costs for diagnosis and therapy of one AIDS patient at the Frankfurt University Clinic, with special reference to the increasing social problem, including social welfare from the time of diagnosis to death].

Exact cost analysis related to an exemplary case of AIDS disease at the university hospital of Frankfurt. There have been calculated the hospital and out patient care costs according to a completely documented case study. The calculation of the indirect costs does concern the payment of sickness benefit as well as social security costs.

Acquired Immunodeficiency Syndrome↗
PubMed1988

[Visceral leishmaniasis (kala-azar) in acquired immunodeficiency syndrome (AIDS)].

A 32-year-old homosexual with AIDS, who until 1985 was a frequent traveller to South America and mediterranean countries, had recurrent bouts of fever, splenomegaly, arthralgias as well as granulocytopenia and anaemia. Liver and bone-marrow punctures were performed to exclude malignant lymphoma and (or) a mycobacterial infection. Both biopsies revealed Leishmania donovani. During administration of sodium stibogluconate (Pentostam) the fever disappeared for a time and there was clinical improvement, but further treatment was limited because of thrombocytopenia. In patients with AIDS who have splenomegaly with nonspecific fever, visceral leishmaniasis must be considered in the differential diagnosis even outside of endemic regions.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Disseminated visceral leishmaniasis (kala azar) in acquired immunodeficiency syndrome (AIDS).

The case of an AIDS patient with visceral leishmaniasis diagnosed by bone marrow and liver biopsy is reported. Despite the infrequent association between HIV infection and leishmaniasis pathologists and clinicians alike should be alerted to the possibility of leishmaniasis occurring as yet another opportunistic infection in the setting of HIV-induced immunodeficiency.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Autopsy findings in AIDS--a histopathological analysis of fifty cases.

Fifty consecutive AIDS autopsy cases were evaluated. All subjects showed one or more opportunistic infections and malignancies included in the AIDS case definition with cytomegalovirus and Kaposi's sarcoma being most prevalent. Mycobacterial and cryptococcal infections occurred only infrequently. Most patients of our series after successful treatment of Pneumocystis carinii pneumonia or cerebral toxoplasmosis later succumbed to less treatable conditions like disseminated cytomegalovirus or fungal infections or malignant lymphoma. In the absence of specific treatment for the HIV infection leading to these lethal complications special emphasis must be put on the prevention of HIV transmission and spread.

Acquired Immunodeficiency Syndrome↗
PubMed1987

[Cryptosporidium infections in AIDS].

Investigations for cryptosporidia were carried out on 250 fecal samples from 131 HIV-positive patients between December 1985 and July 1986 with kinyoun carbolfuchsin staining. Cryptosporidial oocysts could be detected in six homosexual men. All of the cryptosporidia excretors had symptoms of enteritis. The clinical course and the prognosis depended on the immunological resistance of the host. Five patients with pronounced immune defect had therapy-resistant chronic diarrhea. In one patient with a slight immune defect, the cryptosporidial infection cured spontaneously. A spacial separation of cryptosporidia excretors and patients with weakened resistance is to be considered in view of the possible severe progress form with low tendency to cure and the still lacking specific chemotherapy.

Acquired Immunodeficiency Syndrome↗
PubMed1987

Isolation frequency and growth properties of HIV-variants: multiple simultaneous variants in a patient demonstrated by molecular cloning.

The biological properties and efficiency of isolation of different HIV (LAV/HTLV III, ARV, and AAV) subtypes were evaluated by recovering and growing HIV on fresh peripheral human lymphocytes. Cultures for virus isolation were performed from more than 180 German AIDS, ARC, LAS, and virus-exposed asymptomatic patients. The virus isolation rate depended on the state of health of the patients being close to 80% in AIDS patients, 30-40% in ARC/LAS patients, and lower in asymptomatic HIV seropositive patients. The cytopathic effects of the HIV isolates obtained on lymphocyte-cell cultures ranged from no effect to marked syncytia formation and cytopathogenicity. Marked differences were also observed in the replication rate of the various isolates. These properties were stable in all in vitro passages of the viruses performed so far and allowed to tentatively define four subtypes of HIV. In the majority of AIDS cases with neurological symptoms well-growing strains were obtained from peripheral blood, while all but two isolates from the cerebrospinal fluid of the same patients grew remarkably slowly and to only low titres on lymphocytes, suggesting that selection of variants for growth at specific sites of the body occurs. For one of the most cytopathogenic strains the influence of several variables of culture conditions (cell type, corticosteroids, IL-2, and polybrene) on virus replication was studied. Apart from polybrene, all parameters strongly influenced replication.

AIDS-Related Complex↗