Biomedical subjects

E B Hoffman

Publications and source records attributed to E B Hoffman.

26 records · Page 2Linked to original sources

PubMed1990

Severe disseminated staphylococcal disease associated with osteitis and septic arthritis.

We reviewed the records of 1,156 patients treated for acute staphylococcal osteitis or septic arthritis over a 12-year period; 38 had been critically ill with evidence of multiple-organ involvement and 30 (79%) had features of the toxic shock syndrome. The mortality rate of these 38 patients was 13% and the long-term orthopaedic complication rate was 39%. The diagnosis and management of patients with osteitis or septic arthritis, disseminated staphylococcal disease, and the toxic shock syndrome is discussed.

Acute Disease↗

PubMed1990

Neonatal osteomyelitis.

Thirty-four neonates with osteomyelitis were reviewed. The hip (19) was the most common site involved. Swelling and pseudoparalysis were the most significant local signs. Radiographic abnormalities, such as metaphyseal rarefaction and/or joint subluxation were found on the initial radiographs in 18 of the 19 hips involved. All patients were treated with antibiotics and all infections involving joints were drained surgically. Good results were achieved in 75% of all sites and in 68% of hips.

Anti-Bacterial Agents↗

PubMedDate not supplied

Posterior iliac osteotomy in ischiopagus tetrapus twins.

Eight hemipelvises in ischiopagus tetrapus conjoined twins were assessed retrospectively to determine whether posterior iliac osteotomy is appropriate to reconstruct pelvic symmetry. Although clinical and radiological similarity exists with classic bladder exstrophy, axial and three-dimensional computed tomography showed the pelvic deformity to be very different. In classic bladder exstrophy, the deformity is one of shortening and external rotation of the anterior segment, and external rotation of the posterior segment. The deformity in the ischiopagus tetrapus pelvis is purely one of external rotation of the posterior segment. Posterior iliac osteotomy alone was therefore able to restore pelvic symmetry in seven of the eight hemipelvises, and prevented rediastasis of the symphysis pubis in all patients.

Bladder Exstrophy↗

PubMedDate not supplied

Traumatic atlantoaxial subluxation in children.

We report four children who sustained traumatic atlantoaxial subluxation without a rotatory component, underlying congenital anomaly, or inflammatory cause. Three patients were involved in motor vehicle accidents as pedestrians, and one sustained a rugby injury to his neck. Only one patient sustained an associated head injury. Two patients had neurologic signs on admission directly attributable to the atlantoaxial subluxation. The signs resolved after reduction and stabilization of the subluxation. Three patients were treated conservatively and one operatively. To date, all four patients have had a satisfactory outcome.

Accidents, Traffic↗

PubMedDate not supplied

Chronic granulomatous disease presenting with osteomyelitis: favorable response to treatment with interferon-gamma.

A 3-year-old boy with chronic granulomatous disease presented with abscesses related to underlying osteomyelitis. Treatment with appropriate antibiotics resulted in resistance of the organisms. Treatment with interferon-gamma was encouraging in that it caused the osteomyelitis to heal and prevented its relapse when used as long-term prophylaxis.

Child, Preschool↗

PubMedDate not supplied

Midtarsal dislocations in children.

Four children with midtarsal dislocations are described. Two of the four patients had a delay in diagnosis because of associated midtarsal injuries detracting from the main pathology. The key pathology was a dislocation or subluxation of the calcaneocuboid joint. The lateral radiograph was the most consistent view in making the diagnosis.

Child↗

PubMedDate not supplied

Pyogenic spondylitis and early tuberculous spondylitis in children: differential diagnosis with standard radiographs and computed tomography.

In a study of 23 patients, axial computed tomography (CT) was the most valuable modality to differentiate between early tuberculous (10 patients) and pyogenic spondylitis (13 patients). Tuberculous spondylitis showed large erosions with calcification, whereas pyogenic spondylitis showed multiple small well-defined erosions, mostly without calcification. Both groups had large or small paravertebral soft tissue swelling, with accompanying calcification, in six of the 10 patients with tuberculous spondylitis and in only one patient with pyogenic spondylitis. Tuberculous spondylitis showed larger intraspinal extradural abscesses, with calcification in 50% of cases, whereas pyogenic spondylitis demonstrated no calcification.

Child↗

PubMedDate not supplied

Diaphyseal primary subacute osteomyelitis in children.

Six patients with subacute diaphyseal osteomyelitis of 200 with acute osteomyelitis who were seen and treated at the Red Cross Children's Hospital in a 3-year period (1985-1987) are reported. All six patients had a history of a minimum of 2 weeks' duration and the radiographic picture of a linear periosteal reaction, which was either single or laminated. This radiographic picture was indistinguishable from round cell tumors of bone. The final diagnosis was established by a histology consistent with a subacute osteomyelitis. In two patients, a positive culture of Staphylococcus aureus was obtained. All of the patients healed after treatment with cloxacillin. Radiographic resolution was noted in all patients within 6 months of treatment.

Biopsy↗