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Biomedical subjects

E B Holm

Publications and source records attributed to E B Holm.

6 recordsLinked to original sources

[Complications of pediatric diseases].

A review of all medical reports on patients discharged from the Central Hospital in Viborg from 1974 to 1986 after measles (M), mumps (F), German measles (R), or chickenpox (S) revealed a total of 294 patients suffering from complications, 128 after M, 142 after F, 9 after R, and 15 after S. A total of 373 complications was encountered. Neurologic complications were seen in 166 cases most frequently after F, and superinfection was seen in 105 cases most frequently after M. Sequelae were seen in 3 cases of M, 2 cases of S. and in one case of R. In all cases sequelae were caused by damage in the central nervous system. More widespread use of vaccination is urged.

Age Factors

[Acute non-suppurative encephalitis in children].

From July 1973 to January 1988, 66 children aged from three months to 14 years, 36 boys and 29 girls, were seen at the Central Hospital, Viborg, with acute encephalitis. In 25 cases the encephalitis was caused by mumps, in eight by measles, in six by chicken pox, one by herpes simplex, one by RS-virus, and one by mycoplasma. One case was seen after vaccination, one after infection and in 22 cases the cause of the encephalitis remained unknown. Sequelae were seen in 17 cases. The risk of encephalitis after mumps, measles, and rubella is an important argument for the use of MMR-vaccination and the risk of encephalitis after chickenpox may justify a vaccination campaign against chickenpox.

Acute Disease

Myasthenia gravis in the county of Viborg, Denmark.

The epidemiology of myasthenia gravis was studied in a Danish countryside county with 230,760 inhabitants. The incidence rate was 10.4 per million per year and the prevalence rate, 125 per million. The female to male ratio was 1.4 to 1. The diagnoses were delayed from a few hours to 6 years, most frequently on behalf of ophthalmologic diagnoses. A high incidence rate and a considerable diagnostic delay indicate that a number of patients suffering from myasthenia gravis are misdiagnosed, leading to unfortunate psychologic events.

Adolescent

[Mumps].

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Adolescent

Absolute bioavailability of terbutaline from a CR-granulate in asthmatic children.

The study aimed at finding the absolute bioavailability of terbutaline of a newly developed CR-granulate. Eight asthmatic children, aged 8-13 years, were given 3 mg of terbutaline as the CR-granulate, concomitant with the intravenous administration of 0.100 mg of deuterium-labelled terbutaline. The labelling of the intravenous dose made possible a separation, in the analytical step, of terbutaline originating from the intravenous and oral administration. Maximal plasma concentration, 8.7 (range: 4.9-15.2) nmol l-1, was reached after 4.7 (2.2-6.0) h. Absolute bioavailability was 10.8 (7.63-16.4) per cent. The parameter values were similar to those found after administration of terbutaline CR-tablets to adults. The CR-formulation is easily swallowed and can be dosed twice daily. Thus it should be a good alternative to elixir or plain tablets, dosed three times a day.

Adolescent