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Biomedical subjects

E B Kenney

Publications and source records attributed to E B Kenney.

At least 55 records · Page 3Linked to original sources
PubMed1983

The effect of metronidazole on human periodontal disease. A clinical and bacteriological study.

Fifteen female subjects undergoing treatment for nonspecific vaginitis with metronidazole 250 mg q.i.d. for 7 days were studied. Clinical and microbiological evaluations were carried out initially and at 2 and 4 weeks. The following parameters were measured in two quadrants: plaque index, sulcular bleeding index, pocket depth, attachment level and amount of gingival fluid. Dark field microscopy was used to quantitate the plaque constituents. One quadrant was subjected to root planing at the initial visit; the other quadrant received no therapy. No oral hygiene instructions were given. All the clinical parameters were significantly reduced in all areas. Gingival fluid, sulcular bleeding index and pocket depth showed greater improvement in the root-planed quadrant compared to the nonroot-planed quadrant. Dark field microscopy showed decreases in fusiforms, curved rods and spirochetes in all areas with a concomitant increase in cocci. The root-planed quadrant showed no significant differences in microbiological aspects when compared to the nonplaned quadrant. Clinically, metronidazole therapy resulted in improvement of periodontal status with some additional but small enhancement due to root planing. Microbiologically, metronidazole dramatically changed the quality of plaque with no supplemental effect when root planing was added.

Adult↗
PubMed1976

The effect of topical application of dextran on the gingiva of the beagle dog.

Dextrans derived from Leuconostoc mesenteroides were placed on clinically healthy gingiva of Beagle dogs once a day for 21 days. Control gingival tissues received saline. Both healthy controls and dextran-treated tissues were brushed daily. Inflamed control tissues were obtained by allowing plaque to accumulate for 21 days. Tissues receiving daily application of dextran solutions developed chronic gingival inflammation but displayed no clinical signs of gingivitis. Healthy control gingival tissues showed no clinical signs of gingivitis and minor histologic inflammatory changes. Tissues exposed to dental plaque showed the typical clinical and histological inflammatory changes of gingivitis. Thus dextran, a substance similar to the extracellular polysaccharide found in dental plaque, was able to penetrate the sulcular epithelium, enter healthy gingival connective tissue and cause chronic inflammation. This connective tissue inflammation occurred without inducing any of the clinical signs of gingivitis. Therefore, it is concluded that dextran produced one component of the gingivitis response, chronic histologic inflammation, independent of another major component of the disease, clinical inflammation.

Administration, Topical↗
PubMed1975

The effect of cigarette smoking on anaerobiosis in the oral cavity.

Nineteen young adult male smokers were compared to 19 adult male nonsmokers to determine if cigarette smoking resulted in any changes to anaerobic bacteria in dental plaque, to intraoral oxidation-reduction potential (Eh) levels, or to intraoral pH. There was no statistical difference between smokers and nonsmokers in the proportion of anaerobic bacteria found in dental plaque. There were no significant differences between smokers and nonsmokers with respect to the resting Eh in the floor of the mouth nor in the Eh in the region of buccal surface of the upper molars. The smoking of one cigarette resulted in a dramatic fall in Eh in both intraoral regions and this occurred in all subjects, both smokers and nonsmokers. The magnitude of this fall in Eh was similar in both groups. There were also uniform increases in pH, but these pH changes were much smaller in magnitude.

Adult↗