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Biomedical subjects

E B Renvoize

Publications and source records attributed to E B Renvoize.

At least 19 recordsLinked to original sources

What are hospitals doing about clinical guidelines?

OBJECTIVES: To assess the attitudes of senior hospital staff towards clinical guidelines, and to ascertain the perceived extent and benefits of their local use; to identify those hospitals with current or planned future written strategies for the systematic development of clinical guidelines, and the staff responsible for leading them; and to establish the essential elements of existing strategies, and the methods used to ensure the proper development, dissemination, implementation, and evaluation of local guidelines. DESIGN: Cross sectional survey. PARTICIPANTS: Senior staff of 270 acute hospitals in the United Kingdom (response rate 202/270 (75%)) in 1995. RESULTS: 197/199 (99%) of respondents thought that clinical guidelines were a good idea, and 176/196 (90%) were aware of some guideline activity occurring within their hospitals. The most important benefits of local guideline activity were increased healthcare efficiency and effectiveness, greater consistency of treatment, and team building. 174/194 (90%) of respondents were in favour of the development of a readily accessible national repository of evidence-based clinical guidelines. 38/201 (19%) of respondents had a clinical guidelines strategy and a further 91/201 (45%) said that they had plans to develop one in the near future. The need to improve clinical outcomes was most often reported as the reason for developing a strategy. Medical directors most commonly had formal responsibility to lead the strategy, but someone without formal responsibility ran the operation in half the hospitals. Only 18/36 (50%) of strategies gave advice on the development of guidelines; and only a few strategies made explicit statements on which clinical services to target for guideline development, or the methods to be used for their validation and promotion. Some strategies lacked explicit statements on methods to monitor adherence, routine review, and update of guidelines. Internal literature searches (29/31 (94%)), the use of national guidelines (29/32 (91%)), local consensus conferences (28/32 (88%)), and peer group review (21/24 (88%)) were the most popular methods of validation used in hospitals with a strategy. Methods used to promote the dissemination, implementation, and evaluation of clinical guidelines included clinical audit (31/32 (97%)), peer review (25/30 (83%)), continuing education (23/29 (79%)), targeting of opinion leaders (17/26 (65%)), use of structured case notes (14/31 (45%)), patient mediated interventions (9/26 (35%)), and patient specific reminders (8/26 (31%)). CONCLUSIONS: Most senior hospital staff have a favourable attitude towards clinical guidelines. Most hospitals are undertaking some guideline activity, but few seem to be doing so within a locally agreed hospital wide strategy in which guideline development, dissemination, implementation, and evaluation are systematically considered. Many of the current methods used to validate guidelines locally are inadequate. Evidence-based clinical guidelines should be developed nationally, leaving hospitals to focus their energies on the local adaptation, dissemination, implementation, and evaluation of such guidelines. Only in this way will local guidelines achieve their full potential to improve clinical care and patient outcomes.

Attitude of Health Personnel↗

Recorded psychiatric morbidity in a large prison for male remanded and sentenced prisoners.

The purpose of the study was to establish the proportion of remanded and convicted prisoners who were known from their records to have a psychiatric history. The inmate medical records of 834 out of 864 inmates resident on one day at HM Prison, Leeds, were studied. There was a recorded history of 23 per cent having seen a psychiatrist, 15 per cent having taken drugs and 16 per cent having a history of depression or self-harm. Out of 43 inmates interviewed, 18 admitted to failing to report such a history upon reception. There were eight former long-stay psychiatric patients, but only two of these had been in a hospital other than a special hospital or Regional Secure Unit. Out of the 36 residents of the hospital wing, 33 had psychiatric disorders and 10 were awaiting transfer to NHS or private psychiatric services. Various recommendations are made which may lead to an improvement in the medical reception procedure, more informed screening for suicide risk and mental disorder, greater understanding of the psychiatric histories of patients, an audit of prison health care and more effective planning of aftercare.

Adult↗

Mental illness and the late Victorians: a study of patients admitted to three asylums in York, 1880-1884.

The case histories of the patients newly admitted to the Retreat Asylum in York between 1880-1884 were examined. Most patients were aged under 50 years, single and non-Quaker, and a majority satisfied the Research Diagnostic Criteria for a diagnosis of schizophrenia or affective disorder. It was found that 72.9% of the patients were deluded, the most common delusions being of persecution, grandeur and guilt; in 34.9% of the deluded patients, the delusion had a religious content. Suicidal ideation was recorded in the case records of 31.4% of the patients. Drug therapy was commonly prescribed, a history of assault on other patients or asylum staff was recorded in 38.1% of the patients, and 11% of patients were force fed at some stage during their illness. Within a year of admission 49.1% of the patients were discharged, the prognosis being better for patients with an affective illness than for schizophrenia, but 31.4% remained in the asylum for five or more years. The characteristics, alleged causes of mental illness, and treatment and outcome of the Retreat patients were compared with those of patients admitted during the same period to the two other York asylums which served different socio-economic groups of the population. Mortality rates were higher in the asylum admitting mainly pauper patients, and possible reasons for this are explored.

Adult↗

A sero-epidemiological study of conventional infectious agents in Alzheimer's disease.

Serum antibody titres to Adenovirus, Chlamydia Group B, Coxiella burnettii, Cytomegalovirus, Herpes simplex virus, Influenza A, Influenza B, Measles and Mycoplasma pneumoniae were measured in 33 patients with a clinical diagnosis of Alzheimer's disease, and in 28 non-demented controls suffering from functional psychiatric disorders. No statistically significant differences were found between the patients and controls, and it is concluded that these agents play no role in the aetiology of Alzheimer's disease.

Aged↗

Delusional infestation and dementia: a case report.

The case of an 82-year-old woman with delusional infestation and senile dementia of the Alzheimer type is reported. Her symptoms of infestation ceased dramatically with pimozide given for 5 weeks, and did not recur during follow-up over 9 months. The importance of organic factors in patients with this disorder is emphasised.

Aged↗

Folie à deux in Down's syndrome. A case report.

A case of folie à deux in a 29 year-old man with Down's syndrome, whose mother had a paranoid psychosis, is described. Successful treatment of the mother's illness also resulted in full recovery of the son without the need for medication.

Adult↗

Anniversary reactions.

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Anniversaries and Special Events↗

Identical twins discordant for presenile dementia of the Alzheimer type.

In genetically proven identical female twins, discordant for presenile dementia of the Alzheimer type, the affected twin began to dement at the age of 49, and died 15 years later; the diagnosis was confirmed at post-mortem. The surviving twin remains clinically unaffected 20 years after the onset of dementia in her sister. Environmental aetiological factors are postulated to account for this discordance.

Alzheimer Disease↗

ABO and Rhesus blood groups in Alzheimer's disease.

ABO and rhesus (Rh) blood groups were examined in 124 patients with presenile dementia of the Alzheimer type (PDAT) and senile dementia of the Alzheimer type (SDAT), and their distribution was compared with controls. No significant associations between these blood groups and Alzheimer's disease (AD) were found after statistical correction for multiple comparisons.

ABO Blood-Group System↗

An HLA and family study of Alzheimer's disease.

Histocompatibility antigens were examined in 124 patients with Alzheimer's disease (AD), and the frequency of HLA-B15 was found to be significantly increased over controls. Pooling of data from the present and similar studies suggests that AD is not strongly associated with any particular HLA antigen, although there may be a weak association with HLA-A2, B15 and Cw3. In a family study of 34 patients with AD, secondary cases of AD were identified in 9.7% of the first-degree relatives, and cases of presenile dementia and senile dementia of the Alzheimer type were found to occur within individual families.

Aged↗

Cytomegalovirus infection and Alzheimer's disease.

Serum antibody titres to cytomegalovirus (CMV) were measured in 113 patients with Alzheimer's disease (AD), and 39 non-demented controls suffering from chronic functional psychoses. AD patients and controls had similar CMV antibody titres, and conventional CMV activity was not detected in post-mortem samples from eight AD patients. It is therefore unlikely that the CMV play any causal role in most cases of AD. The possession of the histocompatibility antigen HLA-B15 was significantly correlated with raised levels of CMV antibody in the AD patients, which suggests that HLA-B15 may be associated with an enhanced immune response to CMV.

Aged↗