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Biomedical subjects

E B Schlesinger

Publications and source records attributed to E B Schlesinger.

At least 19 recordsLinked to original sources
PubMed1990

The significance of genetic contributions and markers in disorders of spinal structure.

Clinical evidence suggests that a moiety of patients with low back syndrome refractory to conventional treatment may embody a pleiotropic expression of Marfan-like pathology of support tissue. Individuals in the suspect group display a triad of clinical findings including refractory low back syndrome, certain dural ectasias, and a susceptibility to protracted reactions after lumbar puncture. Certain stigmata found in these patients and their families are among those commonly seen in Marfan's disease. The concept, if valid, has important implications affecting therapeutic choices and may offer insights into unexplained failures. The finding of significant family involvement strengthens the possibility of a heritable substratum for this category of low back disease.

Adolescent↗
PubMed1981

Cerebellar metastasis from ovarian carcinoma.

The most common sources of metastatic disease of the brain are lung and breast carcinoma. Considerably less common are metastases from malignant melanoma, hypernephroma, and carcinomas of the alimentary tract. All other sources are rare. This report presents a unusual case of a single cerebellar metastatic lesion from ovarian carcinoma.

Carcinoma↗
PubMed1981

Hydromyelia: clinical presentation and comparison of modalities of treatment.

The clinical and radiographic features of 60 cases of hydromyelia area discussed. A combination of motor and sensory symptoms and signs is the usual presentation, but pure motor or sensory forms of the disease are not infrequent. Pain and scoliosis are usually associated with a high degree of blockage. A normal spinal fluid protein content in the presence of an enlarged spinal cord is of diagnostic value. Important radiographic clues include widening of the spinal cord without venous stagnation and collapse of the spinal cord visualized with the patient in the upright position. Metrizamide computed tomography is now used routinely, and the contrast agent may at times appear in the dilated central spinal canal. Decompression of the foramen magnum is the treatment of choice in the presence of an associated Arnold-Chiari malformation and is the treatment most likely to succeed. In selected cases, decompressive laminectomy and syringostomy may be indicated. Percutaneous spinal cord puncture is a safe diagnostic-therapeutic procedure which, surprisingly, may afford relief equal to that of more drastic measures. Therefore, percutaneous spinal cord puncture may be an option of therapeutic value in a disorder that is frustrating to treat.

Adolescent↗
PubMed1979

BCNU and steroids in the viral-induced dog brain tumor.

Schmidt-Ruppin strain of Rous Sarcoma was inoculated intracerebrally into 27 newborn beagle dogs. Fourteen days after viral inoculation, 13 of the dogs were given intravenous BCNU (1 mg/kg). The other 14 were given the same volume of intravenous saline in a randomized, double-blinded fashion. Ninety percent of all dogs developed intracranial tumors. Radionuclide (mercury 197) brain scans were done on each dog at 2-week intervals. Median survival was 113 days in the BCNU group and 115 days in the placebo group (P > .99). Unequivocally positive radionuclide brain scans were detected in 5 dogs treated with BCNU and in 2 of the controls. There were no gross or microscopic differences at autopsy between treated and nontreated animals. BCNU, as given in this animal brain tumor model, did not demonstrate any oncolytic effect. An improvement in sequential brain scans was detected in 2 other dogs in response to Dexamethasone, which was given in a double-blinded, cross-over controlled fashion. Computerized tomography clearly demonstrated the tumor in two cases.

Animals↗
PubMed1978

Treatment of tumours of the posterior part of the third ventricle and the pineal region: a long term follow-up.

This paper represents a further investigation into the origninal series, with additional cases from N.I.N.U. This follow-up has been immeasureably enhanced by the availability of the EMI Scanner. It seems clear that there continues to be adequate evidence that the use of shunting procedures, followed by radiotherapy, is a rational approach to tumours of the pineal and posterior third ventricular region. Short of more extensive evidence to the contrary, we feel that it remains the method of choice in the initial treatment of these difficult lesions.

Adolescent↗
PubMed1976

The value of sequential scanning in the detection of metastatic tumors.

The usefulness of sequential scanning, three and 24 hours after injection of 197Hg chlormerodrin in the detection of metastatic tumors of the brain has been demonstrated. The 24-hour scan was positive in 29% of the cases in which a metastatic lesion was suspected although the three-hour scan was negative, and the 24-hour scan also revealed additional masses in another 20%. The delayed scan helped to demarcate the actual location of the lesion in 24% of the cases in which the three-hour scan was graded merely suspicious. It is concluded that the addition of a 24-hour scan strongly reinforces the statistical accuracy of the 197Hg brain scan, and thus is of practical clinical importance.

Brain Neoplasms↗