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Biomedical subjects

E B Schmidt

Publications and source records attributed to E B Schmidt.

At least 91 records · Page 5Linked to original sources
PubMed1986

Platelet number and volume during myocardial infarction in relation to infarct size.

Platelet number and mean platelet volume (MPV) were measured in 100 patients with acute chest pain, 41 with acute myocardial infarction (AMI), 33 with angina pectoris (AP) and 26 with non-coronary event (NCE), and compared with 21 controls. We found no significant difference in platelet count on admission in the patient groups, but it was lower compared with controls. There were no significant differences in MPV between the patient groups nor between patients and controls. Thirty patients with AMI were followed for 10 days and showed an initial 12% fall in platelet count followed by a 36% increase. Initially there was an increase in MPV (2%) followed by a fall (8%). The fall in platelet count and increase in MPV correlated with infarct size (maximum activity of lactate dehydrogenase (LDH)) and might reflect consumption of platelets. The precise role of platelets in the process of infarction is still unknown.

Aged↗
PubMed1986

Diagnostic value of the concentration of M-component in initial classification of monoclonal gammopathy.

The diagnostic value of the concentration of a serum M-component in initial classification of monoclonal gammopathy into malignant monoclonal gammopathy (MMG) and monoclonal gammopathy of undetermined significance (MGUS) was evaluated in 315 consecutive individuals with IgG, IgA or IgM type M-components. The final diagnosis was MMG in 84 and MGUS in 231 patients. Serum concentration was significantly highest in MMG, but for all 3 kinds of M-components, overlapping serum concentrations between MMG and MGUS were found. Highest efficiency was reached with a serum concentration of 30.2 g/l for IgG, 26.6 g/l for IgA and 22.7 g/l for IgM. Using these values, an initial correct classification was achieved in 0.90 of IgG M-components, in 0.91 of IgA M-components and in 0.79 of IgM M-components. Normal levels of uninvolved immunoglobulins were found to point strongly to MGUS.

Humans↗
PubMed1985

Exercise decreases the platelet sensitivity to prostacyclin in patients with angina pectoris.

Earlier reports have indicated, that the platelet sensitivity to prostacyclin (PGI2) is decreased in patients with coronary heart disease and that the onset of a spontaneous anginal attack is associated with a further decrease in platelet sensitivity to PGI2. We studied platelet function before and after bicycle exercise testing in 23 patients with angina pectoris and in 11 healthy males. We could not demonstrate any difference in platelet sensitivity to PGI2 between patients with angina pectoris and the controls neither before or after exercise testing. The platelet sensitivity to PGI2 decreased significantly after exercise, both in patients and in controls, but the decrease was not related to the development of myocardial ischemia. Our results could be interpreted in terms of different pathophysiological roles of platelets in spontaneous and in exercise-induced myocardial ischemia.

Angina Pectoris↗
PubMed1985

Monoclonal gammopathy in general practice. Diagnostic value of typing and quantitation of immunoglobulins.

The diagnostic value of typing and quantitation of immunoglobulins were investigated in 88 persons with monoclonal gammopathy diagnosed in general practice. Of the 88 persons, 13 had malignant monoclonal gammopathy (MMG) and 75 monoclonal gammopathy of undetermined significance (MGUS). IgG was the immunoglobulin most often associated with a benign disorder. The higher the concentration of M-component was, the higher too was the frequency of MMG. All 40 persons with normal levels of immunoglobulins had MGUS. Suppression of immunoglobulins other than the M-component was found in 69% with MMG and 20% with MGUS. The combination of an elevated level of monoclonal immunoglobulin and suppression of other immunoglobulins was seen in 69% with MMG, but in only 12% with MGUS. The results from typing and quantitating may serve to indicate whether further investigations are justified in patients not suspected of MMG, but in whom a M-component is found.

Aged↗
PubMed1985

Monoclonal gammopathy in general practice. Associated clinical conditions.

The clinical diagnoses in all 88 cases of monoclonal gammopathy, detected by general practitioners in Northern Jutland during a 3-year period, were investigated: 15% had malignant monoclonal gammopathy, 5% had non-haematologic cancers, and in 80% a benign disorder was found. These results indicate that the finding of a monoclonal gammopathy in general practice deserves attention, but it is rarely accompanied by a grave prognosis. Malignant monoclonal gammopathy should be suspected, but search for another type of cancer is not indicated.

Aged↗
PubMed1985

Detection rate and clinical significance of monoclonal gammopathy in different age groups in the population of Northern Jutland, Denmark.

All serum protein electrophoresis performed in the period 1 May 1979-30 April 1982 in the county of Northern Jutland, Denmark, were studied to find the annual detection rate and the clinical significance of a monoclonal gammopathy (MG) in different age groups. A monoclonal gammopathy was found in 325 persons (185 males and 140 females). The average annual detection rate of MG per 100,000 individuals increased with age in both sexes (p less than 0.01, Kolmogorov test). The lowest and highest detection rate for males/females were 2.8/3.3 (age group less than 50 years) and 236.8/100.3 (age group greater than or equal to 80 years) per 100,000 individuals, respectively. Monoclonal gammopathy was associated with a B-cell malignancy in 28 percent (95% confidence limits 23.9-32.4%) of the persons irrespective of sex and age.

Age Factors↗
PubMed1983

Verapamil does not alter platelet function in patients with recent myocardial infarction.

Reports concerning the influence of the calcium antagonist verapamil on platelet function are conflicting. In a randomized double blind trial including 52 patients with acute myocardial infarction the effect of verapamil 120 mg given perorally three times a day for three months was investigated. There were no alterations in cutaneous bleeding time, platelet aggregate ratio or platelet aggregation induced by ADP or collagen. Verapamil administered in therapeutic doses does not seem to affect platelet function in patients with ischaemic heart disease.

Aged↗
PubMed1983

The effect of N-6 and N-3 polyunsaturated fatty acids on hemostasis, blood lipids and blood pressure.

Diverging results from studies of marine oil supplementation to western diets initiated the undertaking of a double-blind crossover study, with administration to healthy volunteers for 4 weeks of either 10 g of fish oil or 10 g of vegetable oil. Each oil containing approx. 40% of n-3 and n-6 polyunsaturated fatty acids (PUFA) respectively. During the n-3 PUFA period, systolic blood pressure, plasma total lipids, triglycerides and VLDL concentrations fell significantly whereas plasma antithrombin-III (AT-III) rose. Cutaneous bleeding time increased significantly. In contrast only AT-III rose during the n-6 PUFA feeding, however, more marked than during the n-3 oil period. It is concluded that a n-3 PUFA oil supplement to the western diet exerts an effect that generally is considered as beneficial in terms of the risk of developing cardiovascular diseases. It is in this respect superior to that of n-6 PUFA, stressing the necessity of a more differentiated approach to advice on dietary PUFA enrichment than presently is exerted.

Adult↗