[Role of the ideas of V. V. Parin in the development of space medicine].
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Biomedical subjects
Publications and source records attributed to E B Shul'zhenko.
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Before and after 24-hour water immersion test subjects performed a submaximal workload on a bicycle ergometer. Changes in their hematocrit, circulating plasma volume and fluid balance were compared with those during immersion. As a result, the test subjects were subdivided into two groups. For one group the workload was very hard; adaptation to immersion was accompanied by significant renal losses of fluid from the intra- and extravascular space. The bicycle ergometry test after immersion demonstrated a decrease of exercise tolerance combined with circulatory disorders. The other group showed a higher exercise tolerance; after immersion exercise tolerance remained high at the expense of the reserves that maintained optimal blood supply to the working muscles.
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Healthy male test subjects, aged 20 to 45, were exposed to acceleration of +6 Gx for 1200 sec and of +10 Gx for 60 sec. Three gradients of the centrifuge acceleration were used in the latter case. In every experimental run the test subjects were exposed to accelerations while breathing air or a helium-oxygen atmosphere. The positive effect of the helium-oxygen atmosphere was seen in an increase of the respiration intensity and in an elevation of pulmonary ventilation and gas exchange. This may be associated with a decline of the aerodynamic resistance to breathing. The positive effect of the helium-oxygen atmosphere was more pronounced during accelerations of +4 to 8 Gx and depended on the total exposure time.
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This paper presents medical results obtained in a Salyut-7 8-month manned mission in which a physician-cosmonaut took part. The results include body mass and height measurements, vestibular studies, cardiovascular studies at rest and in response to staged functional loads (with echocardiographic examinations accentuated), metabolic and hormonal studies. The paper also gives information about medical aspects of extravehicular activities. It is emphasized that during the mission both old and new methods of research were used and medical results of preceding flights were considered.
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It was demonstrated that renal excretion of fluid, osmotically active substances and electrolytes could be reduced, using low gravitational exposures (+GZ). The degree and duration of water and electrolyte retention were different with respect to the experimental time. The major physiological mechanisms of the changes in fluid-electrolyte metabolism were: a decrease in the glomerular filtration rate and a change in water and ion transport in renal tubules.
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