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Biomedical subjects

E B Silberstein

Publications and source records attributed to E B Silberstein.

At least 19 recordsLinked to original sources
PubMed1979

Radionuclide therapy of hematologic disorders.

32P is effective therapy for polycythemia and primary thrombocytosis. The Polycythemia Vera Study Group is comparing radioactive phosphorus with alkylating agents to determine relative efficacy. Less well investigated is the effectiveness of 32P vs. busulfan in chronic granulocytic leukemia. Endolymphatic administration of radiopharmaceuticals may play a role in the therapy of infradiaphragmatic lymphoma. Among the radionuclides that have at times been used in hematology are 32P, 198Au 24Na, 76As, 89Sr, 52Mb, 54Mn, 91Y, 95Zr, 95Cb, 111Ag, 109Pd, 131I, 185W, and 192Ir. As stated, 32P has proven single most efficacious agent. The hematologic diseases that have been treated include both malignant and benign conditions. Among the malignant conditions are polycythemia vera, agnogenic myeloid metaplasia, thrombocythemia, leukemia, Hodgkin's disease, and multiple myeloma. Hemophilia, and Osler--Weber--Rendu disease are among the benign entities in which the agents have been tried. Polycythemia and thrombocythemia remain those in which the greatest success has been achieved.

Gold Radioisotopes↗
PubMed1979

The relationship of information density to pre-set counts obtained in brain, lung and liver scintigraphy.

The total number of counts required per view for brain and lung scintigraphy to achieve information or count density (CD) of 1 000 counts/cm2 and 2 000 counts/cm2 for liver scans was examined. To achieve these CDs, 600 000 counts per view are required for brain scans. For the lung, 500 000 counts in anterior and posterior views are required; 400 000 counts in the lateral view are sufficient. For 2 000 CD in the liver scan, 600 000 counts should be obtained in the anterior view and 500 000 in the right lateral. This number of counts assures the desired CD in 97% of cases.

Brain↗
PubMed1978

An evaluation of undergraduate family care programs.

Evaluation of the many new family care programs (FCP), and others of similar intent, however defined, is as essential as determining the value of any other curriculum change. Replies to a questionnaire from 101 U.S. and 15 Canadian medical schools indicated that 80% of the former and 93% of the latter had FCPs; 35% and 29%, respectively, were not evaluating their program by any method. No single evaluative technique was used by more than 42% of the American medical schools. A review of the literature on FCPs frequently indicated that the conclusions that could be drawn about the programs were ambiguous. Students in the University of Cincinnati Medical Center FCPs elected family practice or pediatric internships significantly more often than did the FCP nonparticipants, but they indicated that the program had little effect on this choice, despite almost uniformly favorable testimonials. We discuss the possibility that FCPs may be educating the wrong students, that FCPs, if not reinforced in other clinical areas, may have few lasting effects on student attitudes or career choice, and that we may be asking the wrong questions, and with inadequate methods.

Adult↗
PubMed1978

Radionuclide imaging of Meckel's diverticulum in children.

Fifty-eight children were studied for the presence of Meckel's diverticulum by scintigraphy with 99mTc-pertechnetate. Meckel's diverticulum was found at surgery in 6 of 6 patients with positive radionuclide studies and in 2 of 48 patients with negative studies. Four studies could not be interpreted because of widespread intestinal activity. Using the criteria described in this paper, false-positive readings did not occur.

Adolescent↗
PubMed1978

Clinical comparison of technetium-99m diphosphonate and pyrophosphate in bone scintigraphy: concise communication.

Thirty patients had bone scintigraphy with both Tc-99m pyrophosphate (Tc-PPi) and Tc-99m diphosphonate (Tc-HEDP). The images were given a composite rating for quality and the basis of three sets of criteria, and were also compared for the number of lesions detected by each agent. The two agents provided no difference in scan quality. Nevertheless, in ten of the 30 patients, at least two of the three readers detected with Tc-HEDP lesions that were not seen with Tc-PPi, and in two such cases all three readers considered the Tc-PPi scan normal. In another of these ten, two of three readers felt the Tc-PPi image was norm, whereas all three detected the lesion with Tc-HEDP. The reverse never occurred (P less than 0.01).

Bone Neoplasms↗
PubMed1977

Radionuclide imaging. Use in diagnosis of osteomyelitis in children.

Forty-four children were studied for the presence of osteomyelitis by scintigraphy using Tc 99m etidronate tin complex. Evidence of osteomyelitis on radionuclide images was found in 16 of 19 patients considered to have osteomyelitis by their attending physicians. Bone scintigraphic changes were noted prior to or in the absence of roentgenographic abnormalities in 10 of 19 patients. Cases of acute hematogenous osteomyelitis, chronic osteomyelitis, and osteomyelitis caused by penetrating trauma and contiguous infection were identified. Three bone infarctions were correctly diagnosed.

Bone Diseases↗
PubMed1977

Physiologic and biologic behavior of autologous canine 131L-fibrinogen labeled by a chloramine-T method.

Autologous canine 131I-fibrinogen labeled by a chloramine-T method was examined to determine whether the fibrinogen had been altered by the iodination procedure as suggested by other investigators. Before and after radioiodination, clottability of the fibrinogen was always equal to or greater than 89 percent. Gel chromatography studies revealed that labeled fibrinogen behaved as unlabeled fibrinogen and no high molecular weight material was found. Gamma camera scintigraphy reflected the chromatography results, as iodinated material did not appear in the liver or spleen until 48 to 72 hours. The slow-moving component of the whole blood clearance curves, respresenting undenatured fibrinogen, had a mean half-life of 61.4 +/- 5.1 hours (+/- S.E.M.) and comprised 51.5 +/- 7.5 percent of the initial activity. Similarly, a mean falf-life of 53.4 +/- 2.0 hours and 59.6 +/- 7.7 percent initial activity wwere attributed to fibrinogen according to the plasma clearance curves as determined by trichloracetic acid precipitation. The results clearly demonstrated that chloramine-T iodination of fibrinogen can yield an excellent product, biologically and chemically, which is free from macroaggregates.

Animals↗
PubMed1976

Cancer diagnosis. The role of tumor-imaging radiopharmaceuticals.

Several radiopharmaceuticals have recently been shown to have a considerable affinity for malignant tissue. All the tumor-seeking radiopharmaceuticals in current use are nonspecific and may also be picked up by benign tumors and infectious processes, including abscess and granuloma. The sensitivity of the tumor-imaging procedure depends on the radiopharmaceutical employed, the type of tumor, its size and location, and previous or current treatment. Gallium-67 citrate (67Ga), the most widely used tumor-seeking radiopharmaceutical, seems to have its greatest value in detecting bronchogenic carcinomas irrespective of cell type. The sensitivity for lung cancer in 489 studies was 93 per cent. Gallium-67 is also of great value in the staging of Hodgkin's disease, in which its sensitivity is 87 per cent. Non-Hdgkin's lymphomas are detected with only slightly lower sensitivity. There is, in fact, evidence that 67Ga is at least complemenatry, if not more sensitive than lymphangiography, in the staging of lymphoma. However, adenocarcinomas originating in the gastrointestinal tract are detected by 67Ga with a sensitivity of only about 40 per cent, whereas various chelates of bleomycin (including 111In-Bleo, 99mTc-Bleo and 57Co-Bleo) detect adenocarcinoma of the gastrointestinal tract with considerably higher sensitivity. In the few studies available comparing bleomycin chelates, 57Co-Bleo and 99mTc-Bleo appear to be more sensitive in detecting tumor than 111In-Bleo. Other tumor-seeking radiopharmaceuticasl which have been employed with somewhat less success include selenium compounds, labeled pyrimidines, several inorganic cations, lanthanide chelates and labeled proteins. Yet to be evaulated clinically is the efficacy of radiolabeled antibodies which are specific for tumor antigens, such as 131I-anti-CEA (carcinoembryonic antigen).

Antibodies, Neoplasm↗
PubMed1975

Thermographically measured normal skin temperature asymmetry in the human male.

The detection of thermal asymmetry may lead to the diagnosis of significant disease states, especially those of a neoplastic or vascular nature. Estimates of acceptable thermal asymmetry have been made; thermal asymmetry has not previously been quantified in normal subjects. In 10 normal male volunteers, ages 17-38, thermal difference between symmetric areas of the chest, abdomen, and back never exceeded 1 degrees C. Statistical treatment of these data suggests that thermal differences in excess of this in the male are abnormal.

Abdomen↗