[Mass spectrometry in the complex study of brain life support systems after neurosurgical interventions].
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Brain↗
Biomedical subjects
E B Sirovskiĭ
Publications and source records attributed to E B Sirovskiĭ.
[Pressure-volume ratio in the craniospinal cavity in supra- and subtentorial pathology. I. Changes in cerebrospinal fluid pressure in cerebrospinal fluid compression and decompression of the brain].
The p-V dependence in the craniospinal cavity was studied by the method of dosaged change in the cerebrospinal fluid volume in 15 neurooncological patients who underwent operation for tumor of the posterior cranial fossa in the chiasmal-sellar area. It is shown that this dependence, reflecting the biophysical properties of the intracranial system, has distinguishing features in patients with supra- and subtentorial pathology. For instance, in FP values close to zero the resilience of the intracranial system is higher in patients with supratentorial processes than in patients with subtentorial pathology. In artificial c.s.f. compression, intracranial system resilience grows gradually in patients with basal pathology and increases much more rapidly in patients with subtentorial pathology. The authors discuss the possible causes of the difference in P-V dependence in the groups of patients who were examined and the significance of the obtained information in substantiating intensive therapy in the immediate postoperative period.
Biomechanical Phenomena↗
[Pressure-volume relation in the craniospinal cavity in the presence of supra- and subtentorial pathology. II. Changes in local intracerebral pressure subsequent to cerebrospinal fluid compression and decompression of the brain].
Comparative measurements of cerebrospinal fluid pressure (FP) and local intracerebral pressure of the interstitial fluid (ICPIF) both during their spontaneous changes and during artificial changes in cerebrospinal fluid volume were conducted in 15 neuro-oncological patients in the postoperative period. ICPIF pressure was measured by means of a double-layer perforated capsule perceiving pressure of the surrounding interstitial fluid. In patients who underwent removal of a tumor from the posterior cranial fossa ICPIF ranged from -15.8 to +9.5 mm Hg, and FP from 15 to 37.5 mm Hg. In patients subjected to removal of meningioma of the chiasmal-sellar area ICPIF ranged from -11.2 to +0.4 mm Hg, while FP ranged from 4 to 18.7 mm Hg. In artificial decrease in FP to 5 mm Hg and subsequent increase to 35-50 mm Hg, ICPIF changed as a rule, though only slightly (from 0.5 to 10 mm Hg), and often the changes in FP and ICPIF were opposite in direction. In approximately 1/3 of cases ICPIF did not change while the changes in FP ranged from 5 to 50 mm Hg. The possible causes of changes in intracerebral pressure in dosaged FP changes are discussed and a conclusion is drawn that the changes in ICPIF are not a simple reflection of FP dynamics but are linked with the effect exerted on the interstitial fluid by some factors among which are changes in intra-capillary pressure and tension in the cerebral tissue.
Biomechanical Phenomena↗