GASTROINTESTINAL FACTORS IN ASPIRIN ABSORPTION. A QUANTITATIVE STUDY.
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Biomedical subjects
Publications and source records attributed to E B TRUITT.
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Alpha-methyl dihydroxyphenylalanine (alpha-MeDOPA) and alpha-methyl meta-tyrosine (alpha-MMT) do not lower significantly the convulsion thresholds to hexafluorodiethyl ether in the mouse, whereas reserpine and tetrabenazine produce marked lowering of these thresholds. Other workers have shown that alpha-MeDOPA and alpha-MMT decrease brain norepinephrine concentrations much more than brain 5-hydroxytryptamine concentrations, while reserpine and tetrabenazine decrease the brain level of these two amines in a parallel fashion. Thus, the fact that alpha-MeDOPA and alpha-MMT, even in very large doses, do not lower convulsion thresholds and in some cases raise them suggests that the decline in 5-hydroxytryptamine may be implicated in the lowering of convulsion thresholds produced by reserpine and other, similar agents.
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