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Biomedical subjects

E B Timofeeva

Publications and source records attributed to E B Timofeeva.

12 recordsLinked to original sources
PubMed1987

[Effectiveness of pulse-therapy in seronegative spondyloarthritis (preliminary report)].

Pulse-therapy with 6-methylprednisolone was provided to 12 patients (4 with Bekhterev's disease--BD resistant to indomethacin, voltaren and phenylbutazone therapy, 8 with psoriatic arthritis--PA). The drug was injected i.v. at a dose of 1000 mg for 3 days running. A rapid analgetic and antiinflammatory effect was noted in both groups. Ten patients (3 with BD and 8 with PA) demonstrated considerable improvement, 2 improvement. A positive trend in all indices of therapeutic efficacy was noted. In BD change in 33% of indices was statistically significant, in PA in 76%. A decrease in initially elevated serum IgG concentrations in both groups was statistically insignificant. The content of IgM and IgA before treatment was within normal, and the change resulting from pulse-therapy was statistically insignificant. A decrease in initially elevated levels of blood serum circulating immune complexes was statistically significant in both groups. Pulse-therapy was well tolerated.

Adult↗
PubMed1986

[Immunological aspects of pulse therapy in systemic lupus erythematosus].

Twenty SLE patients were examined against a background of pulse-therapy with methylprednisolone. The analysis showed that there was a decrease in the CIC concentration, antibodies to native DNA and an increase in the level of C3c and C4 components of the complement against a background of pulse-therapy. A more rapid time course of the CIC level was noted shortly after pulse-therapy as compared to changes in other immunological indices. A dynamic study of immunological indices in SLE against a background of pulse-therapy was appropriate for a clinical assessment and a study of the mechanisms responsible for the therapeutic efficacy of this method.

Adolescent↗
PubMedDate not supplied

[Immunologic aspects of renal involvement in patients with type II diabetes mellitus].

Besides the known factors contributing to the pathogenesis of diabetic nephropathy, the role of immune mechanisms in types I and II diabetes is discussed of late; the contribution of autoimmune mechanisms to pathogenesis of noninsulin-dependent diabetes (NIDDM) is virtually unknown. Seventy-six patients with NIDDM and 48 with insulin-dependent condition were examined. Under study were levels of antibodies to FxIA and renal glomerular basal membrane antigens in the blood sera of donors and patients with types I and II diabetes, as well as concentrations, size, and pathogenicity of immune complexes. Antibodies to FxIA antigen were detected in patients with both types of diabetes with diabetic nephropathy. Detection of circulating antibodies to FxIA antigen in more than 70% of diabetics in the absence of protein in the urine may be used as a test system for the laboratory diagnosis of diabetic nephropathy prestage and as a criterion for prescription as early as at the initial stages of nephroprotective agents.

Adult↗