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Biomedical subjects

E B Vladimirskaia

Publications and source records attributed to E B Vladimirskaia.

At least 19 recordsLinked to original sources
PubMed1993

[The effect of polychemotherapy on hemopoiesis in acute lymphoblastic leukemia in children].

Bone marrow granulocytic-macrophagal precursors (GMP) and fibroblastic precursors (FP) were measured in 235 children with acute lymphoblastic leukemia (ALL) receiving polychemotherapy (PCT) in progression of the disease. A total of 408 culture investigations were conducted. PCT proved to exert different effects on hemopoiesis during the first acute ALL period and remission. In the former period the target for PCT were blast cells, the course of induction therapy increased the number of GMP, FP and early granulocytic cells. In recurrent ALL the sensitivity of GMP to PCT grew, while FP remained intact. PCT performed in remission resulted in gradual suppression of granulocytopoiesis, GMP beginning from the second remission year. The treatment discontinuation on remission year 3-5 produced enhancement of granulocytosis by all parameters.

Adolescent↗
PubMed1991

[Characteristics of pathogenesis of acute leukemia in children].

The main components of acute leukemia pathogenesis have been considered from the current positions: origination of the leukemic clone, characteristics of leukemia tumor histogenesis, mechanisms of proliferation and differentiation of leukemic cells. The main pathogenetic differences of acute leukemia in children and adults have been traced. The importance of these differences for the clinical picture, prognosis and response to chemotherapy has been analyzed.

Bone Marrow↗
PubMed1990

[Biological principles of the therapy of acute leukemia].

The biological features specific to the tumor growth in acute leukemia are responsible for the disease prognosis and its response to polychemotherapy. Current molecular-biological, karyological, cytological, kinetic, and culture investigation techniques have contributed much to the understanding of the pathogenesis of acute leukemia and may be used as a guide to appropriate disease management.

Acute Disease↗
PubMed1990

[Stromal fibroblasts of normal bone marrow in children].

Reference values of the number and proliferation index (PI) of stromal fibroblasts in children have been presented: CFUf per 10(5) = 57.0 +/- 4.1; CFUf in 1 microliters = 85.4 +/- 8.1; PI = 1.7 +/- 0.05. It has been shown that the number of stromal fibroblasts increases in the prepubertal period, especially in girls. No relationship has been observed between CFUf and the number of platelets and megakaryocytes in the children investigated. Correlation has been established between the number of bone marrow clonogenic fibroblasts and the amount of myelokaryocytes and the number of granulocytic-macrophagal precursors in the bone marrow.

Adolescent↗
PubMed1989

[The dependence of the clonogenic fibroblast proliferation of human bone marrow on the feeder].

The proliferation of human bone marrow stromal fibroblasts depends on the growth factors. Xenogenic bone marrow cells, previously radiated in a dose of 3000 Gy, are shown to be a source of such factors. The human bone marrow cells contain both stimulators and inhibitors of the fibroblast proliferation. The inhibitory activity of the bone marrow cells increases with their concentration in explants. The optimal culture conditions are developed. The efficiency values of the fibroblast cloning in children and adults are presented and compared.

Adult↗
PubMed1988

[Granulocytopoiesis in acute lymphoblastic leukemia in children].

The number, proliferative potential and differentiation potentialities of bone marrow granulocytic-macrophagal precursors were investigated in 130 ALL patients (77 children in the acute period of disease, 53 children in remission) and in the bone marrow of 65 controls without hematologic pathology. A decrease in the number of clonogenic precursors was observed in all stages of acute lymphoblastic leukemia, the decrease being particularly marked in the acute period of disease characterized by substantial bone marrow infiltration by leukemic cells. A decrease in the number of precursors and their proliferative potential was shown to be associated with the influence of leukemic blasts. In remission the numerical reduction of the precursor pool was determined by a cytostatic therapeutic effect. The ability to differentiation of granulocytic and macrophagal clonogenic precursors in ALL children was unchanged.

Adolescent↗
PubMed1988

[Clonogenic cultivation of bone marrow fibroblast precursors in human myeloproliferative diseases].

Techniques of clonogenic cultivation with the application of xenogenous feeder (rabbit irradiated bone marrow) were used to study a number of bone marrow colony-forming cells (CFU-F) in 70 patients. A significant increase of CFU-F is observed in chronic myelocytic leukemia and in hepatosplenomegalies of non-leukemic origin CFU-F decreases considerably in the cases of myelofibrosis. Trypsinisation of the bone marrow taken from the cases of myelofibrosis results in a sharp CFU-F increase.

Bone Marrow↗
PubMed1987

[Regulation of the proliferation of granulocyte-macrophage progenitors in human bone marrow].

The colony stimulating activity (CSA) of bone marrow cells in 50 children with normal bone marrow was studied. A method for quantitative estimation of CSA of bone marrow cells has been suggested. Essential distinctions between CSA of bone marrow cells and that of peripheral blood leukocytes were established considerable decrease mainly at the expense of reduction of the proliferation of colony-forming progenitors was found. CSA of bone marrow cells appears to be a result of complicated interaction between bone marrow adherent and non-adherent fractions. Each of these two fractions produces approximately the similar level of CSA which is lower than that of unfractionated bone marrow. It is supposed that there are two types of granulocyte macrophage progenitors in the human bone marrow which are specifically-sensitive to CSA of leukocytes and bone marrow cells and possess different proliferative potential.

Bone Marrow Cells↗