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Biomedical subjects

E Böhm

Publications and source records attributed to E Böhm.

121 records · Page 7Linked to original sources
PubMedDate not supplied

[Ultrastructure of intravital, postmortem and autolysed fibrin].

Investigations on animal experimental and human tissue material (skin, musculature, liver) with the scanning electron microscope are reported. These studies were carried out to clarify open questions on extravascular fibrin structures after blunt and sharp traumatization of vital and postmortem nature. The network formation which was already characterized earlier as typically vital and the irregular structure of postmortem coagula could be demonstrated even with modification of the traumatization, especially in tissue hematomas. Experimental investigations on autolysis revealed an exceedingly good preservation of the structure of vital coagulum material with massive damage and granular decomposition of fibrin fiber structures produced postmortem. The structural differences in the mode of interlinking of the fibrin was shown up especially clearly by the autolysis, which suggests an application as preparation technique for the question specified. Special modifications of the preparation technique (fixation according to Karnovsky, critical-point drying) did not provide such substantial advantages for routine investigations that they might be generally recommended.

Animals↗
PubMedDate not supplied

[Idiopathic femur head necrosis in the adult--relation to clinical and pathologic-anatomic findings].

For the research here presented, a total of 15 femoral heads with idiopathic necrosis in 15 patients, ranging in the age from 28 to 59 years, were available. In 7 of the histologically examined, in the occasion of endoprosthetic obtained femoral heads, a singular necrosis was to be discovered. In 6 items two attacks of necrosis, in 2 even three attacks could be confined. The comparison of these results with the clinically obtained case history showed that the second as well as the third attack of necrosis occurred during the first two years of the disease and partly obvious due to the increase of subjective symptoms. With the knowledge of these facts, it may be assumed that by means of exact observation of the patients concerned, even after diagnosis has been made, valuable tips to solve the up to now still unknown etiology of idiopathic avascular necrosis could be won.

Adult↗
PubMedDate not supplied

[Morphologic and clinical aspects in the treatment of infected shaft pseudarthrosis].

By means of clinical and morphological findings the procedure in the treatment of infected diaphyseal non-unions is described. The necessity of adequate stabilization--especially with the help of the external fixatoris pointed out. The infected cortex, often as a compromise, has to be left in place in order to give a foundation for periosteal bone grafts. Such cortical bone which is not vascularized and prevents the infect from subsiding has to be removed in a second step from a medullary approach. The defect is then filled up with autologous cancellous grafts. In the forearm the whole infected area of bone can be removed and replaced by a cortico-cancellous graft which is stabilized by internal fixation with a plate.

Bone Transplantation↗
PubMedDate not supplied

[Ultrastructural differences of fibrin coagulation before and after cardiovascular arrest].

The reconstruction of killing offences often requires the differentiation between vital and postmortal blood traces at the sites of action and finding. Earlier investigations seemed to imply the possibility of such a differentiation depending on the different clot structure. We therefore examined clots prior and after 10 minutes of complete occlusion of the upper extremity morphologically and morphometrically with the REM. The morphologic comparison of these clots revealed narrow, round shaped fibrin fiber networks for clots of native blood, whereas clots after occlusion showed linear, rarely connected long fibrin fibers. The morphometry of the fibrin free spaces revealed a significant enlargement of the single fibrin free spaces as well as of the total fibrin free space after occlusion. For capillary blood a significant decrease in fiber diameter was observed after occlusion. The examination of clinical clotting parameters revealed alterations of thrombocyte aggregation for the collagen induction, a slightly reduced thrombocyte retention and slightly steeper flanks in the thromboelastogram after occlusion. The reason for these changes was interpreted as lack of high energetic phosphates in the retraction process as the clotting cascade itself requires a very high amount of these phosphates. Use of these results in the forensic practice will have to take factors as temperature, drying out, surface-structure and many others into account.

Blood Coagulation↗