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Biomedical subjects

E Böttger

Publications and source records attributed to E Böttger.

At least 19 recordsLinked to original sources
PubMed1998

[Gorham-Stout syndrome of the spine. Case report and review of the literature].

Two female patients with Gorham-Stout syndrome (GSS) of the spine are described. One 25 year old patient developed progressive osteolysis of the upper cervical spine over a period of several years but despite gross extent of the disease had no neurological complications. Some bone implanted in order to stabilise the spine was absorbed after only a few weeks. A six year old girl with progressive osteolysis of the thoracic spine developed a reversible trans-section syndrome on several occasions. During an active episode, the spine was stabilised by a titanium implant. In both patients the condition arrested spontaneously. A review of the world literature (175 cases) has indicated that, including our two patients, there were only 15 patients with primary involvement of the spine and 27 patients with secondary involvement. The relatively good prognosis of the condition (mortality 13.3%), which often shows spontaneous arrest, becomes much worse if there is involvement of the spine or thorax because of neurological complications or a chylothorax. Involvement of the spine increases mortality to 33.3%, and to 52% if the thorax is involved. Early diagnosis and the institution of appropriate treatment is therefore essential. For involvement of the spine, a combination of radiotherapy and surgical stabilisation with a titanium implant should be performed since in nearly all patients bone transplants are reabsorbed. For this treatment the patient should be transferred to a neuro-orthopaedic centre.

Adult↗
PubMed1980

[Computer tomographic findings in splenic ruptures, subcapsular haematomas of the spleen and perisplenic abscesses (author's transl)].

The computer tomographic criteria of splenic rupture, new or old haematomas of the spleen (pseudocysts) and perisplenic or subphrenic abscesses are described with reference to three cases. It is shown that all the relevant problems in the pre-operative stage can be clarified by computer tomography, making arteriography unnecessary. The differential diagnosis between old haematomas and perisplenic abscesses can only be made by taking account of the history and other clinical information.

Abscess↗
PubMed1979

[Roentgenological aspects of the cyst lung in newborn (author's transl)].

The article reports on the angiographic identification of a cyst lung in a newborn with special consideration of the differential diagnostic differentiation from lung sequestration which appears similar in the full size radiograph. The article also discusses further differential diagnoses, complications and treatment possibilities of cyst lungs.

Cysts↗
PubMed1979

[Computer tomography for rare soft tissue tumours of the extremities (author's transl)].

Five patients with undiagnosed soft tissue masses in the extremities were examined and in two a pathological diagnosis could be made. One was an extensive, invasive fibroma (desmoid) 22 cm long which could be followed from the thigh almost into the pelvis. It was sharply demarkated form the surrounding muscles and of higher density. The second case was a 12 cm long cavernous haemangioma in the semi-membranosus muscle. This was originally hypo-dense, but showed marked increase in its density after the administration of contrast.

Adolescent↗
PubMed1978

[Splenic cysts: clinical aspects, diagnosis and differential diagnosis].

328 patients were splenectomized from 1967 until 1976. In this period only 4 splenic cysts were observed and operated. Three cysts were posttraumatic and one was of lymphatic origin. The case history and diagnostic management is reported with special reference to preoperative angiography and differential diagnosis. There were no postoperative complications observed.

Adult↗
PubMed1978

[Cranial metaphysial dysplasia (Jackson) (author's transl)].

The typical development of the radiological and clinical features of cranial metaphyseal dysplasia were observed over a period of nine years in one patient. This condition is most commonly confused with metaphyseal dysplasia (Pyle), but differs from the latter in showing pronounced changes in the skull leading to blindness, deafness and facial paralysis as well as club-shaped metaphyses. Cranial metaphyseal dysplasia, particularly in its autosomal recessive form, leads to reduced intelligence and life expectancy of the patients. The diagnosis can usually be made in early childhood.

Abnormalities, Multiple↗
PubMed1978

[Differential diagnosis of metaphyseal dysplasias and osteodysplasty (osteodysplasty of Melnick and Needles) (author's transl)].

The article reports on 4 patients with rare modeling defects of the long bones. These defects are metaphyseal dysplasia, craniometaphyseal dysplasia, frontometaphyseal dysplasia, and osteodysplasty (osteodysplasty of Melnick and Needles). The differential diagnostic criteria are shown in a table to allow diagnosis already in children. This appears important in respect of the therapy to be employed (corrective surgery) and for prognosis, as well as for giving patients proper genetic and vocational advice.

Adolescent↗
PubMed1977

[The angiographic picture of arteriovenous fistulae (author's transl)].

The angiographic appearances and the significance of various angiographic signs are discussed in relation to 12 arteriovenous fistulae demonstrated angiographically in 11 patients. Dilatation of the supplying artery is an indication of the size of the shunt and is particularly prominent in the presence of multiple, congenital microfistulae. The technique developed in our clinic for investigating suspected or known A-V fistulae is described. This technique simplifies the differential diagnosis between the Klippel-Trénaunay syndrome and the prognostically less favourable Weber syndrome.

Adolescent↗
PubMed1977

[Gorlin-Cohen syndrome (frontometaphyseal dysplasia)].

The classical case of a Gorlin-Cohen-Syndrom (= fronto-metaphyseal dysplasis=FMD) is presented. The disease has been mentioned in literature for the first time in 1969 and has been described four times up to now. The characteristic features of this syndrome are very prominent supraorbital ridges with generalized bone dysplasia and joint deformities.

Abnormalities, Multiple↗
PubMed1977

[Lymphografy--a meaningful diagnostic method for classification of gynaecological tumours (author's transl)].

The data about the significance of lymphografy vary between 50% and 90%. The histological findings of the lymphnodes by patients with carcinoma of the cervix uteri operated according to the method of Wertheim-Meigs showed that the findings of lymphografy agree in 68% of the cases with the histological ones. An agreement of lymphografy and histological diagnosis however had been demonstrated in 84% of the cases when there was more than a suspect praetherapeutic lymphografical finding. Although the indication of lymphografy as a searching method is reasonably doubtful in early cancer cases this possibility of an exact verification of the extension of the tumour should not be neglected. An exact praetherapeutic exploration about the consistance of the lymphonodes is of great importance of an optimal therapeutic effect. The presented data show that the lymphografy should be applicated by patients with gynaecological carcinoma if there is no contraindication.

Female↗
PubMed1977

[Clinico-experimental testing for anti-inflammatory activity of external corticosteroids].

Clinical trials of the anti-inflammatory activity of corticosteroids for external use The influence on skin temperature of 4 corticoid-containing formulations and 3 steroid-free bases was tested in 9 subjects in whom no pathological skin changes were present but who were known to be sensitive to metal ions (chromium and nickel). The effect of the preparations on the healthy skin (vasoconstrictive effect) after a duration of action of 2 and 6 h was compared with the effect on skin sites treated subsequently with the contact allergens for a period of 24 h. In the procedure used the trial preparations were allowed to act for 2 and 6 h under occlusive dressing, or for 4 and 8 h, the dressing being removed for 2 h in each case. The allergization produced an increase in temperature at the skin surface which was influenced in various ways by the trial preparations. Whereas no statistically significant differences in the effect of the individual steroid topicals were found the healthy skin, in the evaluatin of the overall anti-inflammatory effect on the pathological skin processes, some distinct differences in effect were found. On comparing the results the following lowing order was obtained for the overall anti-inflammatory effect: 1. Fluprednylidene acetate 0.1% score 4.5, 2. Difluocortolone-valerate 0.1% score 8.5, 3. Fluocortolone trimethylacetate 0.25% + fluocortolone caproate 0.25% score 12, 4. Desoxymethasone 0.1% score 15, The steroid-free bases tested simultaneously did not exhibit clear effects on the temperature in the normal or inflamed skin. The results of the test procedure described are reproducible and can be evaluated by statistical method; the method thus seems appropriate for comparative studies of steroid-containing topicals. The special value in the procedure is the possibility of testing the effect of the preparations directly in a standardised inflammation model which is directly related to use in patients with inflammatory skin diseases, and of establishing in this way in which preparations the anti-inflammatory effect obtained exceeds the general effect common to all steroids.

Administration, Topical↗