Biomedical subjects

E Bajetta

Publications and source records attributed to E Bajetta.

182 records · Page 11Linked to original sources

PubMedDate not supplied

[Colorectal carcinoma: therapeutic approach in patients already treated with metastasis resection].

INTRODUCTION: Fluorouracil is the most wildly used agent in the treatment of advanced colorectal cancer after mastectomy, with an overall response rate of 20%. To improve response rate and survival new therapeutic approaches have been designed such as biochemical modulation of fluorouracil, new schedules of infusion and new drugs. PATIENTS AND METHODS: Many drugs have been used for biochemical modulation of fluorouracil, and leucovorin is very effective. New schedules of infusion such as continuous i.v. infusion of fluorouracil and new drugs like doxifluridine and irinotecan are promising. DISCUSSION: Literature data suggest that biochemical modulation of fluorouracil by lederfolin is effective in the treatment of advanced colorectal cancer such as continuous i.v. infusion of fluorouracil and new drugs, especially doxifluridine, may improve therapeutic effects. CONCLUSION: Chemotherapy with fluorouracil remain the treatment of choice of patients with colorectal cancer. Further studies are necessary to identify the role of new biochemical modulation, new schedule and new drugs.

Antimetabolites, Antineoplastic↗

PubMedDate not supplied

Development of a rapid and ultrasensitive RIA method for estrogen (E2, E1, E1-S) determination with selective solid phase extraction.

The inhibition of the proliferative stimulation exercised by estrogens on neoplastic cells is the goal of all endocrine therapies in breast cancer. Under various circumstances, e.g. with the use of aromatase inhibitors, this result can be obtained by blocking the synthetic pathway and, consequently, by lowering the circulating levels of estradiol (E2), estrone (E1), and estrone sulfate (E1-S). The evaluation of these hormones in plasma could therefore represent a useful indicator of the biological efficacy of the therapy. However, the measurement of circulating steroids in a large series of patients is often a complicated procedure. Indirect methods of extraction are time consuming and expensive while the analytical sensitivity of direct methods is not sufficient to measure the residual levels of E2, E1, and E1-S. In this paper we describe a novel extraction method for the evaluation of plasma levels of E2, E1, and E1-S. This new method consists of solid phase extraction followed by a highly specific radioimmunoassay. The sensitivity of the assay is 0.6 pg/ml, 2.0 pg/ml and 7.0 pg/ml for E2, E1, and E1-S, respectively.

Estradiol↗