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Biomedical subjects

E Balslev

Publications and source records attributed to E Balslev.

16 recordsLinked to original sources
PubMed1992

[Determination of estrogen receptor status in breast cancer by immunocytochemical examination of fine-needle aspirates].

Estrogen receptor status was determined by immunocytochemical examination of fine-needle aspirates in 109 cases of primary invasive breast carcinoma. The results were compared with those from biochemical determination performed on tumor cytosols. Positive agreement was found between qualitative determination (positive/negative) by the two methods in 83% of the cases, and after semiquantitative stratification into three groups the results corresponded in 76%. The predictive value of a positive result on fine-needle aspirate was 96%, and 57% of a negative result. It is concluded that immunocytochemical determination of estrogen receptor status of breast carcinomas on fine-needle aspirate with the applied technique cannot replace the current standard biochemical method.

Aged↗
PubMed1992

The occurrence of pericapillary fibrin in venous hypertension and ischaemic leg ulcers: a histopathological study.

The presence of pericapillary fibrin and complement C3c in the ulcers of 19 patients with venous hypertension and 14 patients with ischaemic leg ulcers was investigated using histochemical and immunohistochemical techniques. There was deposition of fibrin around the capillaries in the central part of the ischaemic ulcers, and the venous hypertension ulcers, and in the non-ulcerated skin around one of the venous hypertension ulcers and two of the ischaemic leg ulcers. The deposition of fibrin is a secondary phenomenon that occurs in the area of ulcerated skin and does not play a major causal role in the formation of chronic leg ulcers.

Aged↗
PubMed1990

Histopathology of acute human immunodeficiency virus exanthema.

Acute exanthema occurs in patients who are human immunodeficiency virus (HIV) positive before they become seropositive. The patients have influenza like symptoms and a macular skin rash on the upper trunk. Histopathological investigation of skin punch biopsy specimens from four patients with acute HIV exanthema showed a normal epidermis and a sparse dermal, mainly perivascular, lymphocytic/histiocytic infiltrate around vessels of the superficial plexus. Histopathological changes of the exanthema of acute HIV infection are non-specific and resemble those of other acute viral exanthema, but when both the histopathological features and the clinical picture are suggestive, the clinician should take into consideration the possibility of HIV infection.

Acquired Immunodeficiency Syndrome↗
PubMed1990

Paget's disease of the nipple. A continuing enigma.

Paget's disease of the nipple, although recognized since 1874, remains in several respects enigmatic. The two main theories of its origin are 1) epidermotropic, i.e. ductal cancer cells migrating to the epidermis of the nipple, and 2) in situ appearance of malignant keratinocytes expressing the multicentricity of breast cancer. The literature is reviewed. Clinical, histologic (including classification), histochemical and electron microscopy observations and diagnostic considerations are discussed. Diagnosis is often delayed, with adverse consequences for treatment. The nipple lesions may be accompanied by ductal carcinoma of local or more extensive in situ type, or invasive tumour. Lymph-node metastasis seems to be the most important prognostic factor. The merits of radical vs. modified radical mastectomy and local excision, with or without adjuvant radiotherapy, are considered. Major studies of breast-conserving management of Paget's disease of the nipple are in progress.

Breast Neoplasms↗
PubMed1989

[Validity of cytologic examination of voided urine in patients with urologic cancer].

Predictive tests for tumour cells in voided urine, compared with cytological and bioptic specimens taken by cystoscopy are quite similar (80-87%) but compared with the degree of malignancy, the sensitivity is least for grade I (62-77%) and greatest for grades II-III (91-94%). The low sensitivity is primarily an expression of the much greater certainty of biopsy investigations. Whereas the choice of the type of sample is not so decisive in experienced hands, the sensitivity in PV-positive test is least in cases of grade I malignant changes and least for grade II cases in PV-negative test.

Evaluation Studies as Topic↗
PubMed1989

Vascular protein deposits in temporal arteritis with special reference to failure of histological findings.

The object of an immunohistochemical search for vascular protein deposits in temporal arteritis is to assess the diagnostic possibilities in cases which are clinically typical but unconfirmed by biopsy results. In a group of older patients with arteritis, however, vascular aging may give rise to intimal thickening and a broad-spectrum deposition of protein. In an inter- and intra-individual comparison of vascular segments with and without arteritis we, however, found a few protein markers in arteritis which are essentially different from those in vascular aging. The intimal thickening and immune reaction in 9 selected marker proteins were graded 0-2, using the tunica media as reference for both properties. Of the nine proteins studied, alpha-2-macroglobulin was significantly increased, not only in segments affected with arteritis, but also in unaffected segments from the same biopsy as compared with biopsies from patients not suffering from this disease. 79% of patients with biopsy-confirmed arteritis also showed a significantly elevated serum alpha-2-macroglobulin as compared to 27% of those having only changes attributed to aging. In conclusion, immunohistochemical demonstration of deposits in the arterial wall and elevated serum levels of alpha-2-macroglobulin substantiate the clinical suspicion of arteritis in the absence of histological and inflammatory changes.

Aged↗
PubMed1989

Immunoreactive opioid peptides in human breast cancer.

Opioid peptides have a variety of actions on inter alia pituitary hormone secretion and the immune system. Release of endogenous opioids has been found to stimulate growth of experimental breast cancers and opiate receptor blockers have reduced the growth of chemically induced rat breast tumors. Opioid peptides may therefore play a role in human breast cancer. Invasive ductal carcinomas from 61 premenopausal women were immunocytochemically analyzed for the presence of opioid peptide immunoreactivity. Positive staining was unambiguously identified in 34 of the tumors (56%). In addition, a medullary carcinoma was positive. In a smaller series of tumors, opioid peptide immunoreactive cells were detected in both primary tumors and metastases. Positive tumor cells were usually few and scattered. Therefore, underestimates of their true frequency of occurrence are likely to have occurred, making accurate correlations with clinical behavior and estrogen receptor status difficult. No correlations with estrogen receptors were established for the unambiguously opioid peptide-positive tumors. Many of the positive tumors also stained with antibodies to gamma-endorphin and alpha-melanocyte-stimulating hormone, suggesting the presence of proopiomelanocortin-derived peptides in them. However, peptides derived from other opioid precursors also may be present in breast cancer.

Breast Neoplasms↗
PubMed1987

Uterus didelphys associated with bilateral dermoid cysts and polycystic ovarian disease.

A case is reported of bilateral dermoid cysts in a 21-year-old woman with a double uterus, hirsutism, oligomenorrhea and markedly elevated serum-androgens. After surgery her menstrual periods and serum-androgens were normalized, and a histological review revealed polycystic changes just beneath the ovarian capsule. No histopathologic evidence of stromal luteinization was found, but a little group of Sertoli cells was seen in the tumors. On the basis of the case report and the literature, the clinical importance of a definitive diagnosis of polycystic ovarian disease in both the non-surgical and the surgical management of the syndrome is discussed.

Adult↗
PubMed1983

Transitional cell carcinoma of the renal collecting tubules ("renal urothelioma").

Carcinoma of the renal collecting tubules is presented, for the first time in the literature, by a systematic description of 18 renal specimens from cases with or without pelvis carcinoma. The study revealed a surprisingly high incidence of carcinoma in the collecting tubules in association with carcinoma of the pelvis (20%), but as a primary tumour, independent of the pelvic growth. In cases of invasive extension, it is also possible to distinguish between the two localizations of carcinoma by histological criteria. The finding of papillary structure, umbrella cells with keratohyaline or parakeratosis demonstrates that we are dealing with a carcinoma originating in the urothelium of the collecting tubules ("renal urothelioma") corresponding entirely to carcinomas of the urinary tract. In a modification of the WHO histological grading of urinary tract tumours, the frequency of grades, I, II, and III is stated for urothelioma and pelvis carcinoma. Perusal of the 18 case records, on the other hand, did not divulge conclusive data as to whether smoking or the use/abuse of analgesics had been operative as carcinogenic factors.

Aged↗
PubMedDate not supplied

Testicular germ cell tumors. Classification based on fine needle aspiration biopsy.

Fine needle aspiration (FNA) biopsy was performed preoperatively on 13 patients with testicular germ cell tumors. The cytologic typing of the tumors was based on the presence or absence of seminoma, embryonal carcinoma, yolk-sac tumor, choriocarcinoma and teratoma in the aspirate. The cytologic findings showed good agreement with the histologic findings. Only four cases showed a single type of tumor; the other nine cases showed as many as four different tumor components. A few characteristic cytologic features proved to be sufficient for tumor typing; this suggests that FNA biopsy cytology can also be useful in identifying metastatic germ cell tumors in extra-gonadal sites.

Biopsy, Needle↗