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Biomedical subjects

E Balzamo

Publications and source records attributed to E Balzamo.

At least 55 records · Page 3Linked to original sources
PubMed1975

Excessive light sensitivity in Papio papio: its variation with age, sex, and geographic origin.

Excessive sensitivity (levels 3 and 4) in a population of 1,122 Papio papio was related with age, sex, and geographical origin. (1) Age. There was no clinical response to intermittent light stimulation under the age of 5 months. These was no difference between animals 6 months to 2 years (J1) and those aged 2 to 4 years (J2). Adult females were less often light sensitive (levels 3 and 4 = 32.9%) than immature females (52.4%). Adult males could usually not be tested, but were probably less often sensitive than immature males. (2) Sex. Immature females (J1 + J2) were more often light sensitive (52.4%) than immature males (38.1%). (3) Geographical origin. No animals from East Senegal (Sansande Region) were very light sensitive. Animals from Casamance were more often light sensitive (56.2%) than those from the Niokolo-Koba National Park (N.K.N.P.) (20%). Of two samples taken at one spot between these two regions, one group resembled the population from Casamance and the second resembled that from the N.K.N.P. This observation raises several questions about the respective roles of genetic, ecological, and ethological factors.

Age Factors↗
PubMed1975

Photically induced epilepsy in Papio papio as a model for drug studies.

Neurophysiological studies employing drugs have been undertaken in the natural syndrome of photically induced epilepsy in the Senegalese baboon Papio papio. GABA-mediated inhibition, both pre- and posysynaptic, plays an important role in the epileptic manifestations seen in this syndrome synapses can significantly modify photically induced epileptic responses, partly as a result of changes in afferent activity. The level of activity in dopaminergic systems can also modify the epileptic signs. Among anticonvulsant drugs, barbiturates and benzodiazepines are very effective against this type of epilepsy, whereas many other drugs are weakly active or toxic. A modification of the natural model (using allylglycine as a priming agent) is convenient for correlating acute anticonvulsant activity and neurological toxicity with plasma concentrations of anticonvulsant agents.

Acetylcholine↗
PubMed1975

[Spike activity recorded at the level of optic tract in a primate, Papio papio].

Spike activity has been recorded, in two young baboons, at the part of the optic tract (O.T.) localized between the chiasma and the lateral geniculate (L.G.) during REM and also slow wave sleep, preceding or not a REM period. These spikes, mono or biphasic, were of 60-200 ms duration and of 30-140 muV amplitude. They occurred generally in bursts (up to 50 spikes); 4 to 10 spikes bursts were the more frequent. These O.T. spikes were assimilated to the L.G. spikes.

Animals↗