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Biomedical subjects

E Barasolo

Publications and source records attributed to E Barasolo.

At least 19 recordsLinked to original sources
PubMed1986

Comparison of diethylstilbestrol, cyproterone acetate and medroxyprogesterone acetate in the treatment of advanced prostatic cancer: final analysis of a randomized phase III trial of the European Organization for Research on Treatment of Cancer Urological Group.

Patients with previously untreated category T3 to T4 Mo or Ml prostatic cancer were allocated randomly to receive 250 mg. cyproterone acetate per day, a loading dose of 500 mg. medroxyprogesterone acetate intramuscularly 3 times weekly for 8 weeks followed by 100 mg. orally twice daily, or 1 mg. diethylstilbestrol 3 times daily in a phase III trial (protocol 30761) performed by the genitourinary tract cooperative group of the European Organization for Research on the Treatment of Cancer. Of 236 patients entered 210 were eligible: 75 received cyproterone acetate, 71 medroxyprogesterone acetate and 64 diethylstilbestrol. Local and distant tumor response, time to progression, survival and toxicity were assessed. Patients treated with medroxyprogesterone acetate had a less favorable course with a shorter duration of survival and time to progression than those treated with the other 2 drugs. There was no significant difference between diethylstilbestrol and cyproterone acetate. Cardiovascular side effects were reported more often in patients treated with diethylstilbestrol than in those treated with cyproterone acetate but severe and lethal cardiovascular toxicity was relatively low in all groups. Other side effects were negligible. Further studies are required to establish the influence of effective hormonal treatment upon survival.

Aged↗
PubMedDate not supplied

[Piezoelectric extracorporeal lithotripsy in ambulatory care].

The surgical approach for stone disease has completely changed during the last decade. Since 1980, ESWL and Endourology (percutaneous nephrolithotomy, ureteroscopy) have been used worldwide in the treatment of nephrolithiasis and today open surgery is necessary only in less than 5% of the cases. The second generation Wolf Piezolith 2300 is a lithotripter for the painless treatment of the majority of renal and ureteral stones. Treatment of stone patients on an out patient basis in a private clinic commenced in 1988 because of the low complications and side effects related to its use. We report the records of the first 70 patients treated in this way and controlled for at least 3 months after the treatment.

Ambulatory Care↗