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Biomedical subjects

E Barrett

Publications and source records attributed to E Barrett.

At least 55 records · Page 3Linked to original sources
PubMed1978

Gas liquid chromatography for detection of bacteriuria: examination for volatile acidic and neutral compounds.

Direct injection of clinically infected urines on porous-polymer columns was investigated to determine which microbial metabolites were consistently detectable, and whether their presence could be used as a reliable index of infection. Chromosorb 101 was found to be the most suitable porous polymer for the detection of microbial metabolites; greater sensitivity of detection was achieved by partial purification of the urine before injection. Acetic acid was the only compound found consistently and it enabled 10(6) microorganisms per ml to be detected in urine. However, as urinary tract infection is diagnosed by the presence of 10(5) organisms or more per ml, our method is insufficiently sensitive for the detection of bacteriuria. Escherichia coli, Enterobacter cloacae, Klebsiella spp, Proteus spp, Stapyhlococcus albus, and Streptocococcus faecalis were detectable by our method but Pseudomonas aeruginosa and Candida albicans were not.

Acetates↗
PubMedDate not supplied

Primary care for women. Assessment and management of headache.

Headache is the seventh leading presenting complaint for ambulatory care encounters in the United States, which accounts for 18.3 million, or 43.2 per 1000, outpatient visits per year. Headache disorders have historically been difficult to tract and study. This problem has been greatly ameliorated since the development, in 1988, of the international headache classification of the International Headache Society. Tension-type headache and migraine headache predominantly affect women, whereas cluster headache predominantly affects men. Advances both in diagnosis and in treatment modalities such as prophylactic treatments, stress reduction and biofeedback, and the use of sumatriptan, have helped to make the management of headache appropriate for nurse-midwives in the primary care setting.

Cluster Headache↗
PubMedDate not supplied

Testing nursing theory cross-culturally.

For nursing science to be recognized globally, nursing theory must be tested in various cultural settings to prove its universality. Below, an overview of a study of cross-cultural nursing theory development in three German-speaking countries of Europe and its implications for clinical practice.

Austria↗
PubMedDate not supplied

Efficacy and safety of erlotinib HCl, an epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor, in patients with advanced ovarian carcinoma: results from a phase II multicenter study.

The aim of this single-arm, phase II study was to estimate the tumor response rate and safety profile of erlotinib HCl (erlotinib, Tarceva, OSI-774) monotherapy in patients with refractory, recurrent, HER1/EGFR-positive epithelial ovarian tumors, who had failed prior taxane and/or platinum-based chemotherapy. Thirty-four patients received 150 mg erlotinib orally once daily for up to 48 weeks or until disease progression or dose-limiting toxicity. Two patients had partial responses, lasting 8+ and 17 weeks, giving an objective response rate of 6% (95% confidence interval [CI], 0.7-19.7%). Fifteen patients (44%) had stable disease, and 17 patients (50%) had progressive disease. Median overall survival was 8 months (95% CI, 5.7-12.7 months), with a 1-year survival rate of 35.3% (95% CI, 19.8-53.5%). Patients with rash survived significantly longer than those without (P= 0.009), correlating with rash grade. Erlotinib was generally well tolerated. The most frequent erlotinib-related adverse events were rash (68%) and diarrhea (38%). Erlotinib had marginal activity but was generally well tolerated. The safety profile appears more favorable than typically experienced with standard chemotherapeutic agents, which is encouraging in these heavily pretreated patients. Combination of erlotinib with chemotherapy or other targeted agents should be considered.

Adult↗
PubMedDate not supplied

The role of salivary function on oropharyngeal colonization.

Aspiration of oropharyngeal flora is the most common route of acquiring Gram-negative pneumonia, a major nosocomial infection. Epidemiologic studies indicate that the elderly are at increased risk for developing these life-threatening pneumonias. The primary objective of this study was to determine the effects of salivary oral defenses against Gram-negative colonization. The study population consisted of 41 male outpatients, age 70 and older, seen at the Denver VAMC. The group included subjects with both diminished and normal salivary flow. Each subject answered a questionnaire regarding overall health, medication use, and symptoms of salivary dysfunction. We then collected whole saliva, unstimulated and stimulated parotid saliva, and performed a throat swab on each patient. For each throat culture, analysis was done to identify Gram-negative bacteria. Flow rates between colonized (n = 6) and noncolonized subjects (n = 34) were compared. While there were no significant differences in the flow rates between the two groups, a trend was noticed in that flow rates were lower for all three flow measures in the colonized group (whole, 22% decrease; unstimulated, 22% decrease; and stimulated, 28% decrease). These preliminary findings suggest that subjects with diminished salivary flow may possibly be at increased risk for oropharyngeal Gram-negative colonization. Research on the role that saliva plays in oropharyngeal bacterial colonization is continuing.

Aged↗
PubMedDate not supplied

A multistate outbreak of Salmonella enterica serotype Baildon associated with domestic raw tomatoes.

Salmonella enterica serotype Baildon, a rare serotype, was recovered from 86 persons in eight states; 87% of illnesses began during a 3-week period ending January 9, 1999. Raw restaurant-prepared tomatoes were implicated in multiple case-control studies. Contamination likely occurred on the farm or during packing; more effective disinfection and prevention strategies are needed.

Adolescent↗