The endothelium and red blood cells as potential targets in PDT-induced vascular stasis.
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Biomedical subjects
Publications and source records attributed to E Ben-Hur.
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The response of a human breast carcinoma cell line (T-47D) to various antitumor agents, gamma irradiation, UV light and heat was studied, using the colony-forming ability technique. Combinations of radiation with drugs and heat were also tested. The resulting survival curves corresponded to one of five patterns: simple exponential, biphasic exponential, threshold exponential, exponential plateau and ineffectual. Whereas the cells were particularly sensitive to gamma irradiation, the response to UV light was normal. The patient from whom this cell line originated did not respond to Methotrexate therapy. The in vitro results correlated with this observation.