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Biomedical subjects

E Bernabeu

Publications and source records attributed to E Bernabeu.

8 recordsLinked to original sources
PubMed2001

Calculation of optical imbalances in ophthalmic lenses using a new algorithm based on the local dioptric power matrix formalism.

We present a new algorithm to calculate the optical imbalances and differential prismatic effects that appear when two eyes look at an object through correcting eyeglasses. These are important magnitudes in ophthalmic optics because large amounts of them will disturb the binocular vision of the spectacle wearer. As a practical application of our algorithm, the distribution of optical imbalances and differential prismatic powers for a pair of progressive addition lenses has been calculated, and we obtain information about the effects of this kind of lens on the binocular vision of the wearer.

Algorithms↗
PubMed2000

Generalized grating imaging using an extended monochromatic light source

It is a well-known fact that one grating can act as an imaging element for another grating when the first is illuminated with an extended monochromatic light source. The conditions for image formation in such a system are studied when the finite size and position of the broad light source are considered. From the presented analysis, expressions for the location and the depth of focus of such images can be derived.

Journal Article↗
PubMed2000

Deflectometric measurement of mechanical spectacle lens deformation.

The warpage of a set of six hard resin spherical lenses was measured when they were compressed by means of the tangential force exerted by a metal frame. The technique employed to measure the lenses improves over previous work both because greater precision is achieved, and because radii of curvature are measured in two perpendicular meridians. In this work, a representative sample of lenses has been used in order to test the way in which deformation depends on lens power and base. It is found that the induced warpage is enough to move the tested lenses between different base families, spoiling the initial design of the manufacturer.

Compressive Strength↗
PubMed1998

A generalization of Prentice's law for lenses with arbitrary refracting surfaces.

A generalization of the Prentice's law is presented in this paper. The idea consists of removing some (but not all) of the approximations that comprise the paraxial approach. In that way, we obtain a new formulation that permits us to compute the prismatic power of a lens made up of arbitrary refracting surfaces, and to improve the precision obtained by Prentice's law when applied to monofocal lenses. The resulting formalism is simple and manageable and its derivation leads us to a precise definition of the local dioptric power matrix, introduced in a previous paper, as well as a better understanding of the same.

Humans↗
PubMed1997

Characterization of 5-HT receptors on human pulmonary artery and vein: functional and binding studies.

1. This study aimed to investigate the 5-hydroxytryptamine (5-HT) receptors mediating contraction of ring preparations isolated from human pulmonary arteries and veins. In functional studies, the responses to 5-HT, sumatriptan, ergotamine, serotonin-O-carboxymethyl-glycyl-tyrosinamide (SCMGT), alpha-methyl 5-HT (alpha-Me) and 2-methyl 5-HT (2-Me) were studied with WAY100635, GR127935, ritanserin, zacopride and SB204070 as antagonists. 2. All agonists produced concentration-dependent contractions of human pulmonary artery and vein preparations. The order of potency (-log ECS0 values) was ergotamine (6.88) > 5-HT (6.41) > or = SCMGT (6.20) = sumatriptan (6.19) > or = alpha-Me (6.04) in the artery, and ergotamine (7.84) > 5-HT (6.96) > sumatriptan (6.60) = alpha-Me (6.56) > SCMGT (6.09) in the vein. The potency of each agonist, except for SCMGT, was greater in vein than in artery preparations. Contractile responses to 5-HT were similar in intact and endothelium-denuded preparations but responses to sumatriptan were enhanced in artery rings without endothelium. 3. GR127935 (1 nM to 0.5 microM) produced an unsurmountable antagonism of the response to 5-HT, sumatriptan, ergotamine and SCMGT. Ritanserin (1 nM to 1 microM) also reduced the maximum contractile responses to 5-HT, ergotamine and alpha-Me in artery and vein preparations without affecting those to sumatriptan and SCMGT. In endothelium-denuded preparations, surmountable antagonism of sumatriptan by GR127935 (in the presence of ritanserin) and of alpha-Me by ritanserin (in the presence of GR127935) allowed for the calculation of the apparent pK(B) values of GR127935 (9.17+/-0.11 in artery and 9.11+/-0.05 in vein) and ritanserin (8.82+/-0.09 in artery and 8.98+/-0.12 in vein). 4. WAY100635 (1 nM to 1 microM), zacopride (1 nM to 1 microM), or SB204070 (1 nM) did not significantly alter the concentration-response curves for 5-HT, sumatriptan, ergotamine, SCMGT or 2-Me in human pulmonary artery or vein thus indicating that 5-HT1A, 5-HT3 and 5-HT4 receptors are presumably not involved in the contractile response to these agonists. 5. Binding studies using selective radioligands for different 5-HT receptors could not detect the presence of 5-HT1A receptor binding in human pulmonary blood vessels whereas the 5-HT(1B/1D) radioligand [3H]-5CT significantly labelled a population of specific binding sites in both vessel types. The presence of 5-HT2A receptors could also be inferred from the level of binding of [3H]-ketanserin to membranes obtained from human pulmonary vessels, although significance could not be reached for arteries. 5-HT4 specific receptor binding was scarce in veins and absent in the case of arteries. 6. These findings indicate that the human pulmonary artery and vein have a mixed functional population of 5-HT(1B/1D) and 5-HT2A receptors mediating the contractile response to 5-HT which is consistent with results of the binding studies.

Abortifacient Agents, Nonsteroidal↗
PubMed1997

Measurement of mechanical warpage in CR-39 lenses.

The warpage of CR-39 ophthalmic spherical lenses of a variety of powers and compressed in the radial direction is measured as a function of the applied tangential force. The lenses are cut with circular shape and then mounted on a frame specially designed to measure the tangential force by means of a calibrated coil spring. The measurements are performed with a high resolution micrometer at different points on the lens surfaces. The warpage of the two surfaces of each lens is calculated and then a quantitative value of surface power variation is given. From these data, vertex power and oblique astigmatism variation are shown. Departure of the surfaces from sphere as a function of the applied tangential force is analysed.

Eyeglasses↗
PubMed1997

Local dioptric power matrix in a progressive addition lens.

In this paper we use the formalism of the Dioptric Power Matrix to visualise and characterise the properties of a Progressive Addition Lens. For progressive addition lenses, the dioptric power matrix is point-dependent, and we have measured its elements over the lens surface by means of an automatic focimeter. We show the obtained contour plots corresponding to the matrix elements, and we compare them with the traditional sphere and cylinder graphs. Although the two representations give the same information, the advantages and disadvantages between them are analysed. The dioptric power matrix method turns out to be specially useful for the computation of prismatic effects along the lens surface.

Eyeglasses↗