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E Bersani

Publications and source records attributed to E Bersani.

7 recordsLinked to original sources
PubMed2001

DNA quadruplexes and dynamical genetics.

In a recent paper, we have put forward the hypothesis that there exist smart purposive mechanisms - tandem repeat length managers - which regulate the length of some tandem repeat, or cause rearrangements, and are almost always driven by some variable number tandem repeat. We have called the framework in which such mechanisms act 'dynamical genetics'. The purpose of this paper is to contribute to lay the foundations of a molecular study of the above mechanisms, by proposing a hypothesis, based on various kinds of supporting evidence and plausibility arguments, about the special importance of DNA quadruplexes for dynamical genetics, and by considering the involved enzymes. This hypothesis states that a tandem repeat length manager acts almost always by monitoring a DNA tract that has the characteristics of being a variable number tandem repeat and/or forming a DNA quadruplex, and that it is almost always driven by at least one of them.

Aging↗
PubMed2001

On new hypotheses about autosomal dominant polycystic kidney disease type 1.

The purpose of this paper is to suggest a partial explanation of the aetiology of autosomal dominant polycystic kidney disease type 1, one of the most common genetic diseases in humans. To this aim we put forward a number of interconnected ideas, based on a number of experimental evidences and plausibility arguments. We stress the major role played by the instability of some genomic tandem repeats, together with the DNA structures known as quadruplexes, the pseudogenes and the gene conversion. The model we propose can be considered a multi-hit generalization of the well-known two-hit model, a generalization that could well have a validity also outside the specific context. We finally provide an indication of the likely guilty DNA segment for the above disease, and we propose a possible simple experimental line of action aimed to confirm or disproof our suggestion.

Age of Onset↗
PubMed2000

A new look at the challenging world of tandem repeats.

Recent research has shown a correlation between some genetic diseases and genomic sequences tandemly repeated a variable and excessive number of times. The excessive number of tandem repeats is usually caused by a progressive expansion, generally considered as purely harmful. We put forward a number of hypotheses: the main one is that the number of repeats has normally a specific significance, and that there exist purposive mechanisms having as a primary function the management of tandem repeats length; such a function is generally useful and only rarely may it become harmful, because of some malfunctioning. These hypotheses are suggested by plausibility arguments, and are supported by a number of recent experimental results. They could provide a simple and unifying explanation of many pathological and non-pathological phenomena replacing many ad hoc assumptions. We finally propose to call the study of the above tandem repeat managing mechanisms 'dynamical genetics'.

Aging↗
PubMed1998

Are only repeated triplets guilty?

It is well known that in some places of the human genome one finds a variable number of tandem repeats of trinucleotides; it is now commonly acknowledged that in many cases an excessive expansion of such a number is the cause of nervous system diseases. Moreover there exist cases of genetic disorders linked with loci where a variable number of tandem repeats of sequences longer than three bases has been found. The abnormal number of these repeats in few cases has been associated with the onset of the disease. Considering the above facts, we have performed an extensive study of published sequences of genes connected with various diseases. We have examined, inside or near those genes, all possible tandem repeats. The analysis has led to the detection of a large number of repeats of both triplets and longer sequences, many of which, as far as we know, had not been pointed out before. The results of our analysis lead us to put forward the hypothesis that in more cases than those till now established, a variable number of tandem repeats of generic sequences, not only of triplets, could be associated with disease onset. Finally we suggest to allocate experimental researches for all the possible tandem repeats and their possible correlation with the neurodegenerative disorders and with other kinds of syndromes.

Base Sequence↗
PubMedDate not supplied

[Infection control in orthodontics: infective agents and modality of transmission. 1].

Adequate attention to prevention of cross-contamination in dental operatory is largely ignored by orthodontists. This occurs for two principal reasons. The first one is that orthodontic patients, usually children, are erroneously considered a low-risk population. The second one is that orthodontic procedures are usually considered nontissue invasive and not able to produce contamination of staff, patients or instruments. Nevertheless, since 1972, we know that we can find HBsAg in saliva too and moreover we cannot exclude to see blood in the mouth of our patients during orthodontic procedures. Furthermore the high volume of patients that orthodontists see every day and the possibility to treat orthodontically adult patients, take the risk of cross-contamination in orthodontic at the same level of other dental practices. The aim of the Authors is to sensitize orthodontists to the risk of cross-contamination giving the latest data of prevalence of hepatitis, tuberculosis and AIDS in adolescent population.

Acquired Immunodeficiency Syndrome↗