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Biomedical subjects

E Bhettay

Publications and source records attributed to E Bhettay.

11 recordsLinked to original sources
PubMed1986

Double-blind study of sulindac and aspirin in juvenile chronic arthritis.

Sulindac (Clinoril; Frosst-MSD), a non-steroidal anti-inflammatory drug was compared with aspirin in a randomized double-blind cross-over controlled study in 30 patients with juvenile chronic arthritis. Sulindac was found to be safe and effective. Although it has the advantage of a twice-a-day dose regimen, both patient and doctor may prefer to be guided by pain relief and cost.

Adolescent↗
PubMed1985

Peritonitis in juvenile chronic arthritis. A report of 2 cases.

Peritonitis is a rare extra-articular manifestation of juvenile chronic arthritis (JCA) which, although mentioned in passing, seems not to have been documented previously. Two patients with systemic-onset JCA, 1 of whom had peritonitis in the early weeks of onset while the second developed peritonitis 10 years after onset, are described.

Adolescent↗
PubMed1985

Meningococcal arthritis.

Meningococcal infection (MI) remains endemic in the Western Cape. A review of 2216 cases in which the condition was diagnosed and notified to the relevant authorities between January 1977 and March 1982 is presented. In 121 patients the disease was complicated by meningococcal arthritis (MA). MI and MA occurred most commonly in the Coloured population; over 50% of patients with MI were less than 2 years of age; and patients with MA were slightly older than the sample mean. The onset of arthritis showed a biphasic pattern with an early peak at 1-2 days and a later peak, heralded by typical recrudescence of fever, at 5-10 days which usually lasted 5-7 days. It was most often monarticular, the knee being the joint most frequently affected. Four cases of isolated MA were also encountered.

Arthritis, Infectious↗
PubMed1978

Double-blind study of ketoprofen and indomethacin in juvenile chronic arthritis.

Ketoprofen (Orudis; Maybaker), whose use has not previously been reported in choldren, was compared with indomethacin in a double-blind crossover trial in 30 children with juvenile chronic arthritis. Both drugs proved to be safe and effective analgesics and anti-inflammatory agents although indomethacin emerged as the preferred drug. Perhaps higher doses of ketoprofen would be safe and more effective. Side-effects were few and mild. The problems of patient compliance and the assessment of pain in children are discussed.

Adolescent↗
PubMed1977

Pure oestrogen-secreting feminizing adrenocortical adenoma.

A 6-year-old boy presented with gynaecomastia. There was no clinical or biochemical evidence of excessive androgenic or glucorticoid activity, but urinary oestrogen levels were raised. An adrenocortical adenoma, demonstrated by x-ray, was surgically removed. Oestrogen levels fell immediately. 3 years later the boy shows complete regression of the gynaecomastia and no signs of recurrence.

Adenoma↗
PubMed1976

Excessive Siamese twinning in Southern Africa.

Twelve sets of conjoined twins have been born in Southern Africa since February 1974. This possibly represents a significant increase in the incidence of Siamese twinning and may be the result of unknown environmental agents. Several of the sets of twins were diagnosed antenatally. In view of the current circumstances a high index of suspicion is probably justified in the presence of maternal hydramnios or fetal malpresentation.

Africa, Southern↗
PubMed1975

Epidemic of conjoined twins in Southern Africa?

Eleven sets of conjoined twins have been born in Southern Africa in a period of just over twelve months. Analysis of the circumstance pertaining to the conception and delivery of these children revealed considerable ethnic, geographic, and socioeconomic differences. It is possible that a ubiquitous environmental agent is a precipitating factor in this situation.

Abnormalities, Severe Teratoid↗
PubMedDate not supplied

Is onset type evaluated during the first 3 months of disease satisfactory for defining the sub-groups of juvenile chronic arthritis? A EULAR Cooperative Study (1983-1986).

This study represents an attempt to collect observations from co-operating countries to evaluate the previously suggested criteria for juvenile chronic arthritis during the onset periods 0-3 and 3-6 months, preferably studied prospectively. Only 267 of 378 forms returned were satisfactory for inclusion because of failure to observe exclusion criteria or insufficient information. Despite this it was possible to conclude that systemic disease represented 25% of the group and that these features tended to decline during the 6 month period. Gut inflammation was seen in 4.5% and the frequency of chronic iridocyclitis increased during the observation period to 4.5%. Variation in joint state during this period suggests that course classification may be important, as 23 of 118 who were pauciarticular at 3 months became polyarticular by six months, but only 46 of 76 who were polyarticular at 3 months remained in this state at six months.

Adolescent↗