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E Bicknell

Publications and source records attributed to E Bicknell.

2 recordsLinked to original sources

Ranking documents with a thesaurus.

This article reports on exploratory experiments in evaluating and improving a thesaurus through studying its effect on retrieval. A formula called DISTANCE was developed to measure the conceptual distance between queries and documents encoded as sets of thesaurus terms. DISTANCE references MeSH (Medical Subject Headings) and assesses the degree of match between a MeSH-encoded query and document. The performance of DISTANCE on MeSH is compared to the performance of people in the assessment of conceptual distance between queries and documents, and is found to simulate with surprising accuracy the human performance. The power of the computer simulation stems both from the tendency of people to rely heavily on broader-than (BT) relations in making decisions about conceptual distance and from the thousands of accurate BT relations in MeSH. One source for discrepancy between the algorithms' measurement of closeness between query and document and people's measurement of closeness between query and document is occasional inconsistency in the BT relations. Our experiments with adding non-BT relations to MeSH showed how these non-BT non-BT relations to MeSH showed how these non-BT relations could improve document ranking, if DISTANCE were also appropriately revised to treat these relations differently from BT relations.

Abstracting and Indexing↗

Local control and distant metastases in primary canine malignant melanomas treated with hyperthermia and/or radiotherapy.

Forty-three dogs with primary malignant melanoma were randomized to receive radiotherapy alone (XRT) or hyperthermia plus radiotherapy (delta + XRT). Tumour responses were analysed in terms of complete response rates, rate of one year disease free survival and the incidence and time to develop distant metastasis. The frequency of complete responses (CR) was greater with adjuvant heat (76 per cent vs 21 per cent for XRT; P = 0.001). A trend towards an improvement in one year disease free survival was observed with delta + XRT (23.8 per cent) as compared with XRT (7.7 per cent), but the difference was not statistically significant. The frequency of distant metastases was not different between the two treatments. Descriptors of intratumoural temperatures achieved during therapy indicated that higher CR rates could be achieved with higher minima. When minima were less than and greater than 20 Equivalent minutes at 43 degrees C (Eq43) the CR rates were 64 and 90 per cent, respectively. One year disease free survival rates and frequencies of distant metastases seemed to be correlated with the intratumoural temperatures as well. This was reflected in analyses examining temperature minima and maxima. Examination of patterns of failure suggested that the most plausible explanation for the correlation between intratumoural temperature and metastases was the high local failure rate (70 per in the heated group). The results of this study emphasize the need for further investigation of the influence of local hyperthermia as a part of curative therapy on the frequency of distant metastases.

Animals↗