[Cytostatic polychemotherapy protocols. I. Neoplasms of the cervicofacial area].
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Biomedical subjects
Publications and source records attributed to E Bild.
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Radiotherapy has a well-established role in palliative care of patients with cancer. It is a local treatment of short duration, the number of fractions should be kept to a minimum without loss of efficacy. Radiotherapy can control superior vena caval obstruction, spinal cord compression, brain metastases, painful bone metastases, and tumor-related bleeding.
In classical irradiation, the local control can be negatively influenced by the accelerated clonogenic tumoral repopulation. A modality of control of this phenomenon can be accelerated hyperfractionated irradiation. The aim of this paper is the study of the effect of this type of irradiation in soft tissue sarcomas on patients of the Radiological-Oncological Clinic Iaşi. Accelerated hyperfractionated irradiation causes a favorable response in the primary tumor with good local tolerance, but the "free of disease" period depends on the aim of irradiation (preoperative, postoperative or single therapeutical procedure).
Cancer of the cervix presents an increasing incidence and mortality in advanced stages. Failure of treatment consists in local recurrence, continuation of evolution or in distant metastasis. One of the strategies of improving the treatment response is the association of radiosensitization chemotherapy with irradiation. The aim of this paper is the study of the effect of cisplatin administration simultaneously with radiotherapy of primary cancer of the cervix and recurrences. This association has proved to be favourable as regards immediate and short period local control with an acceptable digestive and hematologic tolerance (gr. I-II).