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Biomedical subjects

E Bodner

Publications and source records attributed to E Bodner.

At least 37 records · Page 2Linked to original sources

[Intraoperative radiotherapy of malignant pancreatic tumors--initial results].

Thirteen patients suffering from adenocarcinomas of the pancreas were submitted to an intraoperative fast electron "boost" therapy with or without percutaneous photon irradiation. A duodeno-cephalo-pancreatectomy with subsequent irradiation of the tumor bed could be performed in three patients. Ten patients were inoperable because of advanced tumors and formation of metastases. The average survival is 6.5 months, at present six patients are alive without major troubles. An analgetic effect was obtained in ten patients. The first results are encouraging with respect to local control, the little acute and chronic morbidity, and palliation achieved in advanced stages.

Adenocarcinoma

[Intraoperative radiation treatment of carcinoma of the pancreas. Initial clinical results].

Intraoperative radiotherapy (IORT) was administered to 13 patients with carcinoma of the pancreas, using high-velocity electrons of a LINAC accelerator in a single dose of maximally 25 Gy applied directly to the tumour or tumour bed with the abdomen open. There were no disorders of wound healing or other serious early complications which could be ascribed to the radiation. Stomach and intestines were excluded from the radiation field to avoid late radiation damage, such as stenoses or ulcers. The method is particularly indicated for locally non-resectable, non-metastasized pancreatic carcinoma, possibly also as tumour-bed radiation during radical surgery. Patients with distant metastases were not given radiation. First results point to IORT providing lasting improvement of pancreatic pain. It is too early to know whether survival time is favourable influenced.

Aged

Aneurysm of the proper hepatic artery as a rare source of upper gastrointestinal bleeding.

The rare case of the penetration of a partially thrombosed aneurysm into the duodenal bulb causing acute upper gastrointestinal bleeding is described. Besides angiography and CT, ultrasound is the method of choice for early detection. In any case of upper gastrointestinal bleeding of unclear origin the existence of an arteriointestinal fistula should be included in the differential diagnosis.

Aneurysm

Clinically controlled comparative study of suprofen, pentazocine, and placebo. Experience with intramuscular single doses.

Analgesic effect and tolerability of alpha-methyl-4-(2-thienylcarbonyl)-phenylacetic acid (suprofen, Suprol) 200 mg were compared with pentazocine 30 mg and placebo in 88 patients in moderate to severe postoperative pain. The trial was designed as a randomized single-blind study; the test drugs were in single doses (1 ml ampuls) administered by deep intragluteal injection in the upper outer quadrant. The test population was homogeneous as to anamnestic data; the initial intensity of pain was comparable in all three groups. Statistical analysis of the obtained data revealed that at the rating times 30 min to 3 h suprofen was statistically significantly superior to placebo, while after 2 h it was significantly superior to pentazocine. The investigator's final global appreciation of effectiveness states moderate to good effect in 86% of the patients on suprofen, 76% of those on pentazocine, and 63% of the subjects on placebo. Significant difference existed only between suprofen and placebo. Systemic tolerability was considered good to very good in 97% of the subjects in all three treatment groups, whereas local tolerability was considered poor in 2 patients (6.9%) in the group on suprofen. There were no significant differences between the medications. Two subjects each on suprofen and pentazocine and 1 patient on placebo experienced side effects.

Adult

Diagnosis of resectable pancreatic carcinomas by means of ERCP and intraoperative fine-needle biopsy.

In 27 out of 30 resectable carcinomas of the pancreas or the periampullary region we succeeded in recognizing microscopically the malignant nature of the lesion before removing the neoplasm. This was possible 3 times preoperatively during ERCP by means of forceps biopsy taken from the tumorinfiltrated duodenal wall and with 24 patients intraoperatively by means of fine needle biopsy and cytological rapid diagnosis.

Biopsy, Needle

[The influences of anesthetic methods on intraoperative cholangiometry (author's transl)].

The influence of several anaesthetic methods on the tonus of the sphincter of Oddi was investigated in 45 selected patients undergoing cholecystectomy (halothane; fentanyl; fentanyl-droperidol (DHB); all in combination with N2O:O2 and relaxant). The fentanyl collective showed a significant rise of the common bile duct pressure, while the fentanyl-DHB and the halothane collectives did not show any statistical difference in their parameters. From these results neuroleptanalgesia appears to be a surtable method for biliary surgery.

Adult

[Spontaneous perforation of the gall bladder (author's transl)].

We suggest to differentiate between the real spontaneous perforation of the gallbladder and the inflammatory rupture and contrast both with the traumatic form. In one case treated by us we suceeded in finding the cause of the perforation to be an antatomical deficiency. Sterile cholascos should be distinguished from severe bile peritonitis.

Adult

[Neuroma of the cystic nerve stump. No explanation for post-cholecystectomy pain].

The investigation of 20 clinical patients and the autopsy material of 15 cases showed that neuromas of the cystic duct stump following cholecystectomy represent a regular pathomorphologic condition and have no correlation with any postoperative symptoms. Identical morphologic alterations can also be found on arterial stumps after resection of abdominal organs. Therefore, we suggest eliminating the cystic duct neuroma from the list of possible causes of symptoms after cholecystectomy.

Cholecystectomy

[Surgical palliative procedures in patients with carcinoma of the biliary tract (author's transl)].

A report is given of 72 patients suffering from carcinoma of the extrahepatic biliary ducts. Carcinoma of the gallbladder usually grow fast invading the surrounding tissue. Thus cholecystectomy can be performed only as a pallouative procedure in most cases, and partial resection of the liver does not yield better results in general. Carcinoma of the ductus hepaticus usually grows slowly and metastases are formed lately in the course; thus patients usually die due to occlusion of the ducts and jaundice rather than due to the malignancy as such. In these cases good drainage of the bile is essential, in an early stage this can be achieved by placing a tube across the tumor, in later stages an intrahepatic cholangiojejunostomy is to be performed. The technique of this procedure and results obtained in 10 cases are reported.

Aged

[The intramural duodenal diverticulum, a topical variation of the intraluminal duodenal diverticulum (author's transl)].

The intramural duodenal diverticulum is a topical variation of the intraluminal duodenal diverticulum. It is manifested not before adult age by noncharacteristic upper abdominal symptoms. Diagnosis is made by radiologic examinations, the therapy is excision of the diverticulum. Structure and topography of the diverticulum are explained by its embryological development.

Adult

[Palliative treatment of primary and metastatic tumors of the pancreas].

In primary carcinomas of the pancreas the palliative intervention shows worse results than the radical operation according to our experiences. Deviation is only justified with local irresectable tumours as a symptomatic procedure. In cases of metastatic tumours in the pancreas palliative resection may be the only way in order to eliminate complications (jaundice, pains, hemorrhage, tumour induced pancreatitis) caused by these growths. By means of six cases it is demonstrated that palliative surgery can be remarkably successful in cases of metastasis in the pancreas.

Female