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Biomedical subjects

E Boijsen

Publications and source records attributed to E Boijsen.

At least 19 recordsLinked to original sources

Hepatic ultrasonography in the terminally ill patient.

In 53 patients comparison was made between findings at autopsy and findings at ultrasound (US) examination performed shortly before death as the only morphologic diagnostic procedure of the liver during the patient's last year. US was found to be highly accurate. The non-invasiveness and the possibility of examining the patient in bed make US examination in experienced hands the ideal initial diagnostic procedure, especially in terminally ill patients.

Adult

Occlusion of renal arterial tumor supply with absolute ethanol. Experience with 20 cases.

Absolute ethanol was used for renal ablation in 20 patients with carcinoma of the kidney. The procedure was followed by nephrectomy in 6 patients without metastases, all of whom are alive without evidence of recurrence 4 to 20 months after treatment. Fourteen patients with metastatic or locally advanced disease were embolized to palliate pain or hematuria without subsequent nephrectomy. Of these only 2 are alive, 4 and 18 months following the procedure. The technique for ethanol embolization is described and the use of occluding balloon catheters is recommended. No complications were encountered and the 'postembolization syndrome' was less marked as compared with a previous material of equal size where other methods of renal artery occlusion were employed. Microscopic examination in 10 of the infarcted kidneys showed extensive tumor necroses, sometimes with no evidence of viable tumor cells at all. Natural killer cell activity was determined before and 48 hours after renal artery occlusion in 7 patients, showing somewhat increased activity in 4. It is concluded that absolute ethanol is a safe, effective and easily administered agent for the infarction of renal tumors.

Adenocarcinoma

Postmortem examination of the blood supply and vascular pattern of small liver metastases in man.

Thirteen human cadavers with liver metastases were examined. Microfil was injected into the portal vein and hepatic artery. The liver metastases were examined under dissecting microscope, and their vascular supply and patterns were registered. It was found that most metastases had both arterial and portal supply even if the arterial supply dominated. Extensive filling of tumor vessels was observed in both lobes in one liver in which the portal vein of one lobe and the hepatic artery of the other was injected (i.e., the same kind of metastases could be filled from either the hepatic artery or the portal vein). It is suggested that the findings could be of great importance in planning treatment of patients with liver metastases.

Adult

Desensitisation as a means of preventing untoward reactions to ionic contrast media.

Patients with a previous history of anaphylactic reactions to ionic iodinated contrast media were desensitised before a second radiologic examination was performed. The tolerance to the contrast medium was raised by repeated intravenous injections in increasing doses and concentrations. No serious side effects were noted when the examinations with contrast medium was repeated within a few days after the desensitisation. The positive effect of the desensitisation may depend on a successive consumption of complement proteins, probably responsible for the allergic reactions. Therefore, the available amount of complement for some days may be too low for the occurrence of a complement reaction.

Adult

Selection of intravascular contrast media in clinical radiology.

From previous experimental investigations and from the present clinical experience in more than 2000 examinations it is clear that the adverse reactions of Omnipaque are markedly less when compared with those of conventional contrast media for intravascular use. Similar observations have been made for other low osmolar contrast media. These new media should therefore replace the conventional media for intravascular use. The economical consequences are discussed.

Clinical Trials as Topic

Lateral displacement of the right kidney by the ascending colon.

A case of lateral displacement of the lower pole of the right kidney caused by an interposing ascending colon is presented. An interposition of this kind is rare and does not cause any gastrointestinal symptoms but is of differential diagnostic importance. In this case computed tomography was a simple noninvasive procedure for correct diagnosis.

Aged

Angiography in pancreatic disease reevaluated. A prospective and blind evaluation.

Eighty-six consecutive pancreatic angiographies were reviewed prospectively. Ater more than one year 79 of them were "blindly" and independently reviewed by three radiologists. The results concerning accuracy, value three radiologists. The results concerning accuracy, value of superselective technique at malignancy and prediction of extirpability at malignancy were compared. The accuracy was similar, i.e. at malignancy 92 and 86 per cent (mean), respectively, as the prediction of extirpability 88 and 80 per cent (mean), respectively. The value of superselective technique differed considerably, 55 and 14 per cent (mean), respectively, and this is discussed. Pancreatic angiography in relation to CT, ultrasound and ERCP is discussed and considered to be of value late in the diagnostic program.

Aged

Angiography in angiomatous lesions of the gastrointestinal tract.

Twenty patients with various angiomatous lesions of the gastrointestinal tract, such as right-colon angiodysplasia and manifestations of Rendu-Osler-Weber disease and Klippel-Trenaunay syndrome are reported. During the past 15 years an increasing number of such lesions have been reported, diagnosed mainly by angiography. The major complication from these vascular lesions is bleeding. Angiography is the primary method for their detection because of their often small size and is a prerequisite before surgery when reason exists for anticipating an angiomatous lesion as the source of bleeding. However, in certain cases angiography will fail to demonstrate the vascular abnormality or its full extent.

Adolescent

Lesions of the dorsal renal artery in surgery for renal pelvic calculus. A potential cause of renovascular hypertension.

2 cases of lesions of the dorsal renal artery in surgery for renal pelvic calculus are described. In 1 of the cases hypertension developed. Anatomic factors and previous operations predispose to this complication. An arterial complication should be suspected when hypertension develops postoperatively. The blood pressure of patients with known renal vascular complications should be checked repeatedly for several months postoperatively. The diagnosis is radiological, renal angiography being the definite procedure although a reduction of kidney size observed at urography may indicate the vascular lesion.

Adult

Pseudotumor of the renal pelvis caused by renal artery aneusysm.

Urographic abnormalities caused by renal artery aneurysms are discussed on the basis of seven cases. Angiography is the diagnostic procedure of choice to make the correct diagnosis. In cases of completely thrombosed aneurysms angiography may only demonstrate an avascular mass with displacement of vessels. At ultrasound examination renal artery aneurysms should be included in the differential diagnosis of echo-free renal masses.

Adult

Preoperative infusion of mitomycin-C in the bronchial artery in squamous cell carcinoma of the lung.

Bronchial angiography was performed in 9 patients with squamous cell carcinoma of the lung. The tumor-feeding vessel was identified and infused with 10 mg of mitomycin-C (MMC) diluted in saline. At operation after 28 to 48 days complete remission of the tumor had occurred in 2 patients, almost complete in one, partial remission in 2 and a marked regression in 2. In 2 patients no change was noted. No side effects except moderate malaise and slight fever occurred.

Aged