Biomedical subjects

E Boniface

Publications and source records attributed to E Boniface.

7 recordsLinked to original sources

PubMed1990

[Pleurodesis technics].

In patients with recurrent malignant or benign pleural effusion practitioners use specific treatments, but they are then faced with the problem of pleural fluid recurrence. Several techniques of pleurodesis have been used, including drainage, surgery, intrapleural injections and poudrage. From an analysis of the results obtained and from our own experience, we have come to the conclusion that poudrage under thoracoscopy is the best type of pleurodesis.

Antineoplastic Agents↗

PubMed1990

[High-dose cisplatin in primary non resecable non small cell lung cancer. Results of a multicenter prospective study of 57 cases].

In a prospective multicentre phase II study conducted on 57 patients suffering from carcinologically inoperable non small-cell lung carcinoma, three courses of CDDP 200 mg/m2 were administered at random in 2 dosage regimens: either 100 mg/m2 on Day 1 and Day 8 (arm A), or 40 mg/m2 per day during 5 consecutive days (arm B), every 28 days, with supportive hydration. All 27 patients were assessable for toxicity: there were 10 cases of major intolerance (grade 4 n = 3, grade 3 n = 7) and 34 cases of minor intolerance (grades 1 and 2). Only 27 of the patients who received the 3 planned courses (19 in arm A, 8 in arm B) were assessable for effectiveness which was poor: 10.5% objective response in arm A and 0 response in arm B. Thus, high-dose CDDP administered alone was poorly tolerated and insufficiently effective; intermittent infusions during 5 days did not improve tolerance and were totally ineffective.

Adult↗

PubMed1989

[Value of talc administration using thoracoscopy in the symptomatic treatment of recurrent pleurisy. Apropos of 302 cases].

From the data of a retrospective study the authors assess the value of pleural symphysis by talc in the symptomatic treatment of recurrent pleural effusion. 300 patients, 254 of whom were suffering from pleural effusion secondary to cancer and 48 of whom had non-cancerous pleural effusion, were subjected to a thoracoscopy under local anaesthetic allowing the instillation of 5-10 mls of talc powder followed by aspiration drainage for 4-8 days. Out of 270 evaluable cases, an immediate positive result (defined as the absence of any recurrence of the pleural effusion at the drainage site) was obtained in 251 cases or 93% +/- 3% (being 92.1% +/- 3.5% of the cases of pleural cancer and 97.7 +/- 4.5% in cases of non-cancerous pleural effusion). At the end of 6 months there was no recurrence of the effusion in 80.6% of cases. There were 19 early failures (7% +/- 3%) and 25 late failures of whom 9 benefitted from a further attempt at a pleural symphysis (either a pleurectomy, or injection of talc in suspension, or new talc therapy by thoracoscopy). On the whole the complications were minor: pain, fever and rarely more serious: empyema in 6 cases and cancerous nodules down the drainage line in 10 cases. There had been 15 deaths (5.3% +/- 2.6%) during the period of drainage in some very weak and fragile patients. Pleural talcage leads to an improvement in dyspnoea in 82% +/- 7.4% of cases and the general condition was improved in 54% +/- 9.8%.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1987

[Thoracoscopic study of 6 cases of catamenial pneumothorax].

Six new cases seen personally, and 72 cases of catamenial pneumothorax found in the literature have had thoracoscopic talcage. We shall discuss several peculiarities of this syndrome: its relative rarity, symptoms linked to periods, the specific and unique endopleural aspects, confirming certain pathogenetic theories, the first among which is pleural endometriosis. Therapeutic methods are also discussed, stressing the sharing of the association between pleural symphysis surgically and above all by thoracoscopy with antigonadotrophic hormone therapy an association which alone gives good results in 95% of cases.

Adult↗

PubMed1987

[Purulent pleurisy due to Legionella bozemanii].

Since the advent of antibiotics, the bacteriological profile of empyema has changed. It is necessary to recall the recently discovered organisms. Although rarely mentioned in the literature, the Legionnellas may be causative in an empyema. We report a case of empyema to Legionnella bozemanii proven seriologically.

Antibodies, Bacterial↗

PubMed1986

[Bullous dystrophy and bronchopulmonary cancer in young patients].

It is classically admitted that young subjects with bullous dystrophy may develop lung cancer, but this rarely occurs. We report the case of 2 patients under 40 years of age who were found to have bronchial carcinoma. In such cases the clinical signs are not different from those of ordinary bronchial cancer, but the lesions are very often located in the upper lobes, adenocarcinoma is rare in contrast with the usual cancers on scars, the histological diagnosis is difficult and the prognosis usually poor owing to frequent extension to the chest wall. The problem of cancer on bullous dystrophy is essentially that of management of the dystrophy in young subjects: systematic surgery or wait-and-see attitude?

Adult↗

PubMedDate not supplied

[Transthoracic puncture and excavated pulmonary lesion. Diagnostic contribution and value of the extemporaneous cytologic test].

Twenty-six cases of excavated pulmonary masses are reported. In 18 cases malignancy was proven by transparietal needle aspiration. A false-negative result was due to the needle being introduced too centrally and bringing pus, whereas the tumour was an epidermoid carcinoma. The seven non-malignant lesions consisted of abscess in 4 cases, tuberculosis in 1 case and pulmonary embolism in 2 cases. The sensitivity and specificity of the technique were similar to those observed in large series of transparietal needle aspiration of solid masses. Using thin needles and extemporaneous cytology reduced the number of complications: haemothorax 6 percent, haemoptysis 0.4 percent. The authors conclude that in excavated pulmonary masses transparietal needle aspiration provides a diagnosis of malignancy when the radiological and clinical courses and bronchial fibroscopy are inconclusive. Transparietal needle aspiration avoids the need for other investigations, such as exploratory thoracotomy, thereby reducing the cost of diagnosis.

Aged↗