Biomedical subjects

E Bosso

Publications and source records attributed to E Bosso.

3 recordsLinked to original sources

PubMed1999

[Evaluation of the efficacy of flurbiprofen in subjects undergoing extraction of impacted 3d molar].

INTRODUCTION: In this open controlled study the authors evaluated the anti-inflammatory, antalgic and antipyretic efficacy of flurbiprofen in 200 mg capsules as a complementary treatment to antibiotic therapy following minor oral surgery. METHODS: A total of 100 patients of both sexes, aged between 13 and 65, were monitored after extraction of impacted 3rd molar. Patients were treated with flurbiprofen SR 200 mg/day for five days and were controlled on the 2nd and 5th day after surgery. The following parameters were evaluated: painful symptoms, objective examination of mucosa and fever. RESULTS: The results showed the clear efficacy of flurbiprofen SR in reducing all the parameters examined.

Adolescent↗

PubMed1998

[Components of complement in patients with immediate hypersensitivity].

BACKGROUND: This prospective study was undertaken to assess the differences between the levels of the main plasma components of complement in allergic subjects and in those with pseudoallergic clinical manifestations. METHODS: Plasma C3 and C4 were evaluated in a total of 256 subjects examined consecutively at the allergology outpatients clinic of the Internal Medicine Division B, University of Turin. Total IgE and C1-inhibitor levels were also determined in 128 and 44 subjects respectively. RESULTS: C3 and C4 levels were not significantly different (p = 0.398 and p = 0.497) in 123 subjects with a positive and 133 with a negative prick test, nor in allergic subjects with respiratory as opposed to skin symptoms (p = 0.293 and p = 0.462), whereas the C-1 inhibitor was significantly lower (p = 0.046) in the respiratory subgroup. Total IgE was positively correlated with the C3 level (p = 0.036) in 75 allergic subjects. CONCLUSIONS: These findings suggest that plasma C3 and C4 values are not sufficient to discriminate IgE inflammation (positive prick test) and pseudoallergy (negative prick test) in the assessment of subjects with clinically suspected allergy. The positive correlation between IgE synthesis and C3 also points to an interaction between IgE synthesis and C3 regulation proteins in patients with IgE mediated diseases. Further investigation of other acute phase proteins (C reactive protein, fibrinogen) and the cytokines regulating their synthesis (IL-6) in such patients will help to clarify this correlation.

Adolescent↗

PubMed1996

[CD4 lymphocytopenia in patients without significant clinical pathology].

There are different causes of CD4 lymphocytopenia: neoplastic pathology, immunosuppressive therapy or other iatrogenic forms. In addition to these causes, an important role is certainly played by HIV infection which, at the AIDS stage, constantly accompanies progressive CD4 lymphocytopenia, with or without affecting the other lymphocyte components. CD4 lymphocyte deficits not correlated to HIV infection are relatively rare and are not always accompanied by progressive clinical manifestations of immunodeficiency. In the recent past an idiopathic form of CD4 lymphocytopenia (ICL) was recognised whose diagnostic criteria were defined by the Center for Disease Control (CDC) in Atlanta. Cases of ICL association with hepatitis C virus infection have been reported and anomalies partially shared by subjects suffering from common variable hypogammaglobulinemia (CVH) have been reported in some ICL carriers. The CD4 deficit in these patients is not associated with other cellular and/or humoral immunological anomalies and the clinical manifestations, essentially of scant importance, have not shown signs of progression towards severe immunodeficiency syndromes. The authors report 4 subjects with major CD4 deficit whose clinical characteristics do not match idiopathic lymphocytopenia and specific serological tests have excluded HIV infection. No known causes of CD4 lymphocytopenia have been found in these patients and they do not present major signs of clinical damage.

Adult↗