Biomedical subjects

E Botella

Publications and source records attributed to E Botella.

3 recordsLinked to original sources

PubMed2006

[Type IV secretion system and their effectors: an update].

Subversion of eukaryotic hosts by bacterial pathogens requires specialized macromolecules secretion systems delivering virulence factors either into the environment or directly into host cells. Transport of molecules across bacterial and eukaryotic membranes is a process requiring multi-component machineries called secretion systems. This review focuses on the Type IV secretion system. This complex is required for genetic exchange (DNA transport) and secretion of effectors (proteins, macromolecules, DNA-proteins complex) into target cells. They transport a wide variety of substrates including large DNA/protein complexes, multi protein toxins, or individual proteins. We describe recent advances on the structure and the function of this secretion system, their effectors and their effects on the functions of eukaryotic cell.

Bacteria↗

PubMed1999

Hepatoid adenocarcinoma of the urinary bladder. An unusual neoplasm.

A new case of hepatoid adenocarcinoma was diagnosed in fragments obtained at transurethral resection (TUR) from a 71-year-old man who had complained of haematuria. The tumour was composed of trabeculae and small solid nests of polygonal atypical cells simulating hepatocarcinoma, together with glandular areas of an otherwise typical adenocarcinoma. Immunohistochemistry showed cytoplasmic reactivity to AFP, AAT, albumin and CAM 5.2. Membrane reactivity was seen in EMA immunostaining, and there was also positivity to polyclonal CEA following a canalicular pattern. Immunoperoxidase studies of hepatocyte growth factor (HGF) and its receptor, c-met, were positive. Their expression may be related to the aggressive behaviour of this tumour.

Adenocarcinoma↗

PubMed1996

[Teachers' attitudes toward smoking prevention at schools].

Teenage smoking continues to present a significant public health problem. Children begin to smoke in elementary and middle school, although consumption is highest during university studies. In spite of their limitations, school-based campaigns are the most effective weapons against smoking. Spanish educational authorities have developed an interdisciplinary anti-smoking curriculum for health education. In practice, however, the curriculum is not usually implemented. An understating of teachers' attitudes toward such campaigns can lead to their better design, contributing to greater cooperation and better outcome. We therefore surveyed teachers participating in the School-based Smoking Prevention Plan during 1993-1995. Teachers had a generally favorable opinion of the campaign and wanted to continue it; they were well disposed to cooperate more actively with the physicians who carried it out.

Adult↗